1,4-Naphthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages

1,4-Naphthoquinones: Some Biological Properties and Application

(2020) Dmitry Aminin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells

(2020) Alagesan Seetha et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Naphthoquinone Derivatives with Anti-Inflammatory Activity from Mangrove-Derived Endophytic Fungus Talaromyces sp. SK-S009

(2020) Hongju Liu et al.   MOLECULES

Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma

(2020) John M. Hatcher et al.   ACS Medicinal Chemistry Letters

The diverse mechanisms and anticancer potential of naphthoquinones

(2019) Carolina Escardó Pereyra et al.   Cancer Cell International

Thymoquinone: A novel strategy to combat cancer: A review

(2018) Muhammad Imran et al.   BIOMEDICINE & PHARMACOTHERAPY

IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis

(2018) Goutham Pattabiraman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling

(2018) Ying-Ya Cao et al.   Cell Death & Disease

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

(2018) Jack W. Singer et al.   Oncotarget

Simulated annealing molecular dynamics and ligand–receptor contacts analysis for pharmacophore modeling

(2017) Ma'mon M Hatmal et al.   Future Medicinal Chemistry

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of human IRAK1

(2017) Li Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy

(2017) Po-Lin Liao et al.   Scientific Reports

Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities

(2017) Muhammad Jahangir Hossen et al.   Scientific Reports

Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies

(2016) Ma’mon M. Hatmal et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Quinone and its derivatives for energy harvesting and storage materials

(2016) Eun Jin Son et al.   Journal of Materials Chemistry A

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

(2016) Dipa Bhaumik et al.   Aging-US

Designing Irreversible Inhibitors-Worth the Effort?

(2015) Concepción González-Bello   ChemMedChem

TLR4-mediated IRAK1 activation induces TNF-α expression via JNK-dependent NF-κB activation in human bronchial epithelial cells

(2015) Sae Hoon Park et al.   European Journal of Inflammation

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

(2015) Ji-Won Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage

(2015) Bangqing Yuan et al.   Journal of Neuroinflammation

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity

(2015) Rasheed Ahmad et al.   Diabetology & Metabolic Syndrome

IRAK signalling in cancer

(2014) G W Rhyasen et al.   BRITISH JOURNAL OF CANCER

THP-1 cell line: An in vitro cell model for immune modulation approach

(2014) Wasaporn Chanput et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance

(2014) Ajay Jain et al.   Frontiers in Immunology

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

(2013) Jonathan B. Baell et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

IRAK1-Dependent Signaling Mediates Mortality in Polymicrobial Sepsis

(2013) Rachna Chandra et al.   INFLAMMATION

The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review)

(2013) WEI-TIAN WEI et al.   ONCOLOGY REPORTS

Lapachol and its congeners as anticancer agents: a review

(2013) Francesco Epifano et al.   PHYTOCHEMISTRY REVIEWS

Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?

(2013) Heiko Mühl   Frontiers in Immunology

Reduced oxidative tissue damage during endotoxemia in IRAK-1 deficient mice

(2012) Neeraj Singh et al.   MOLECULAR IMMUNOLOGY

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The chemical and biological activities of quinones: overview and implications in analytical detection

(2011) Nahed El-Najjar et al.   PHYTOCHEMISTRY REVIEWS

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor- B Activation

(2010) P. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting TLR/IL-1R Signalling in Human Diseases

(2010) Maria Loiarro et al.   MEDIATORS OF INFLAMMATION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis

(2009) Tomoko Kayashima et al.   CANCER LETTERS

IRAK-4 Inhibitors for Inflammation

(2009) Zhulun Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

IRAK1: A critical signaling mediator of innate immunity

(2007) Sridevi Gottipati et al.   CELLULAR SIGNALLING