Novel imidazo[2,1‐ b ]thiazole‐based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation

Comprehensive research on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides

(2021) Cem Yamali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

E-pharmacophore based virtual screening for identification of dual specific PDE5A and PDE3A inhibitors as potential leads against cardiovascular diseases

(2020) Arooma Maryam et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti‐inflammatory molecule PH46A

(2020) Kit Chan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

(2020) Kesari Lakshmi Manasa et al.   Metabolites

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19

(2019) Ilaria Conti et al.   MOLECULES

Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-b]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors

(2019) Xinshan Deng et al.   MOLECULES

Towards more effective acetylcholinesterase inhibitors: a comprehensive modelling study based on human acetylcholinesterase protein–drug complex

(2019) Abdulilah Ece   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

(2018) Mehlika Dilek Altıntop et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study

(2018) Mustafa Er et al.   Chemistry Central Journal

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ)

(2017) Konrad A. Szychowski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FAK inhibitors in Cancer, a patent review

(2017) Peng-Cheng Lv et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis, characterization, preliminary SAR and molecular docking study of some novel substituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as antifungal agents

(2017) Mustafa Er et al.   MEDICINAL CHEMISTRY RESEARCH

Design, Synthesis, SAR and Molecular Modeling Studies of Novel Imidazo[2,1-b ][1,3,4]Thiadiazole Derivatives as Highly Potent Antimicrobial Agents

(2017) Hakan Tahtaci et al.   Molecular Informatics

Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors

(2016) Fang-Yuan Cao et al.   Anti-Cancer Agents in Medicinal Chemistry

Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment

(2016) M. Roy-Luzarraga et al.   CLINICAL CANCER RESEARCH

Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11

(2015) P. Dao et al.   CANCER LETTERS

Synthesis, Antimicrobial, Anticancer Evaluation of 2-(aryl)-4- Thiazolidinone Derivatives and their QSAR Studies

(2015) Aakash Deep et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines

(2015) Gülşen Akalin Çiftçi et al.   CYTOTECHNOLOGY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1- b ][1,3,4]thiadiazole and imidazo[2,1- b ][1,3]thiazole scaffolds

(2015) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

Improved Angiostatic Activity of Dasatinib by Modulation with Hydrophobic Chains

(2015) Emilia Păunescu et al.   ACS Medicinal Chemistry Letters

Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties

(2014) Ahmed R. Ali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review

(2014) Ekambaram Shanthi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone

(2014) Abdulilah Ece et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Understanding the Roles of FAK in Cancer

(2014) Hyunho Yoon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities

(2013) Abhishek Kumar Jain et al.   Chemical Biology & Drug Design

Novel approaches to glioma drug design and drug screening

(2013) Shivaputra A Patil et al.   Expert Opinion on Drug Discovery

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The discovery of potential cyclin A/CDK2 inhibitors: a combination of 3D QSAR pharmacophore modeling, virtual screening, and molecular docking studies

(2013) Abdulilah Ece et al.   MEDICINAL CHEMISTRY RESEARCH

Recent developments and biological activities of thiazolidinone derivatives: A review

(2012) Abhishek Kumar Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Trial watch: FDA-approved Toll-like receptor agonists for cancer therapy

(2012) Erika Vacchelli et al.   OncoImmunology

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

(2011) Kamal F. M. Atta et al.   MOLECULES

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field

(2010) Devleena Shivakumar et al.   Journal of Chemical Theory and Computation

TDAE-assisted synthesis of new imidazo[2,1- b ]thiazole derivatives as anti-infectious agents

(2009) Thierry Juspin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety

(2009) Nuray Ulusoy Güzeldemirci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An efficient tool for identifying inhibitors based on 3D-QSAR and docking using feature-shape pharmacophore of biologically active conformation – A case study with CDK2/CyclinA

(2007) Nahren Manuel Mascarenhas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY