Redox ticklers and beyond: Naphthoquinone repository in the spotlight against inflammation and associated maladies

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

(2021) Marta Campora et al.   Pharmaceuticals

Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis

(2021) Camila Luiz Gomes et al.   PHYTOCHEMISTRY

An evaluation on potential anti-inflammatory effects of β-lapachone

(2020) Narmin Mokarizadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Naphthoquinone-derivative as a synthetic compound to overcome the antibiotic resistance of methicillin-resistant S. aureus

(2020) Ronghui Song et al.   Communications Biology

Menadione (vitamin K3) inhibits hydrogen sulfide and substance P via NF-кB pathway in caerulein-induced acute pancreatitis and associated lung injury in mice

(2019) Amiti et al.   PANCREATOLOGY

Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer’s Disease and Type-2 Diabetes

(2019) Ashim Paul et al.   ACS Chemical Neuroscience

Inhibition effects of quinones on aldose reductase: Antidiabetic properties

(2019) Yeliz Demir et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Synthesis and cytotoxicity evaluation of glycosidic derivatives of lawsone against breast cancer cell lines

(2019) Flaviano M. Ottoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae

(2019) Mariana Rodrigues Xavier et al.   MOLECULAR BIOLOGY REPORTS

Oral spray containing plant-derived compounds is effective against common oral pathogens

(2018) Wipawee Nittayananta et al.   ARCHIVES OF ORAL BIOLOGY

Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1–42).

(2018) Yu Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2

(2018) Mani Shankar Babu et al.   PLoS One

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

(2018) Donika Ivanova et al.   Redox Biology

Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors

(2018) Marija Pljesa-Ercegovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox regulation of cell state and fate

(2018) Bernice Woon Li Lee et al.   Redox Biology

Perturbation in cellular redox homeostasis: Decisive regulator of T cell mediated immune responses

(2018) Lokesh Gambhir et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats

(2017) Adriano Mollica et al.   FOOD AND CHEMICAL TOXICOLOGY

β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway

(2017) Ji-Ye Kee et al.   PLoS One

In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes

(2017) Ján Vančo et al.   PLoS One

Vitamin K and its analogs: Potential avenues for prostate cancer management

(2017) Subramanyam Dasari et al.   Oncotarget

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

(2017) Jacqueline C. Andrade et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate

(2016) Fabiana Ourique et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

β-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells

(2016) Ji-Ye Kee et al.   INTEGRATIVE CANCER THERAPIES

Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans

(2016) Sweatha V. Nair et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

(2016) Moran Benhar et al.   JOURNAL OF CLINICAL INVESTIGATION

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

(2016) Barbara Marengo et al.   Oxidative Medicine and Cellular Longevity

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

(2016) Valentina Villa et al.   PHARMACOLOGICAL RESEARCH

Antioxidant and Anticancer Activities of Walnut (Juglans regia L.) Protein Hydrolysates Using Different Proteases

(2016) Raheleh Jahanbani et al.   PLANT FOODS FOR HUMAN NUTRITION

Effect Of Walnut Leaf, Coriander And Pomegranate On Blood Glucose And Histopathology Of Pancreas Of Alloxan Induced Diabetic Rats

(2016) G Jelodar et al.   African Journal of Traditional Complementary and Alternative Medicines

Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines

(2015) Xue-Bang Zhang et al.   BMC Complementary and Alternative Medicine

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

(2015) Rahul Checker et al.   CANCER LETTERS

Walnuts (Juglans regia) Chemical Composition and Research in Human Health

(2015) David Hayes et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

(2015) Eun-Jung Lee et al.   Journal of Neuroinflammation

DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate

(2015) Fabiana Ourique et al.   Oxidative Medicine and Cellular Longevity

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

Antimicrobial activity of β-lapachone encapsulated into liposomes against meticillin-resistant Staphylococcus aureus and Cryptococcus neoformans clinical strains

(2015) I.M.F. Cavalcanti et al.   Journal of Global Antimicrobial Resistance

1,4-Naphthoquinone, a pro-oxidant, suppresses immune responses via KEAP-1 glutathionylation

(2014) Lokesh Gambhir et al.   BIOCHEMICAL PHARMACOLOGY

The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives

(2014) Marina Azevedo Souza et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

(2014) Lars-Oliver Klotz et al.   MOLECULES

Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion

(2014) Yun Jeong Kim et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

In vitroCombinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline againstStaphylococcus aureus

(2014) Johana Rondevaldova et al.   PHYTOTHERAPY RESEARCH

Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches

(2014) Mohammad S. Jamal et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Cancer Stem Cells and Their Mechanism of Chemo-Radiation Resistance

(2014) Yonghyun Kim et al.   International Journal of Stem Cells

Chemoprevention of Skin Cancer: Effect of Lawsonia inermis L. (Henna) Leaf Powder and its Pigment Artifact, Lawsone in the Epstein- Barr Virus Early Antigen Activation Assay and in Two-Stage Mouse Skin Carcinogenesis Models

(2013) Govind Kapadia et al.   Anti-Cancer Agents in Medicinal Chemistry

Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives

(2013) Serena Fiorito et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Plumbagin, a Vitamin K3 Analogue, abrogates Lipopolysaccharide-Induced Oxidative Stress, Inflammation and Endotoxic Shock via NF-κB Suppression

(2013) Rahul Checker et al.   INFLAMMATION

Lapachol and its congeners as anticancer agents: a review

(2013) Francesco Epifano et al.   PHYTOCHEMISTRY REVIEWS

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

(2013) Virapong Prachayasittikul et al.   Drug Design Development and Therapy

Synthesis and anti-inflammatory evaluations of β-lapachone derivatives

(2012) Chih-Hua Tseng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Prooxidant Mechanism for the Anticancer and Chemopreventive Properties of Plant Polyphenols

(2012) Husain Yar Khan et al.   CURRENT DRUG TARGETS

Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats

(2012) Christudas Sunil et al.   FOOD AND CHEMICAL TOXICOLOGY

The Natural Anticancer Agent Plumbagin Induces Potent Cytotoxicity in MCF-7 Human Breast Cancer Cells by Inhibiting a PI-5 Kinase for ROS Generation

(2012) Ju-Hee Lee et al.   PLoS One

The Chemical Biology of Naphthoquinones and Its Environmental Implications

(2011) Yoshito Kumagai et al.   Annual Review of Pharmacology and Toxicology

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts

(2011) W.F. Costa et al.   GENETICS AND MOLECULAR RESEARCH

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

(2011) Anlys Olivera et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: Role of NADH and consequences for insulin secretion

(2011) Emma Heart et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells

(2010) J. C. Su et al.   CELL BIOCHEMISTRY AND FUNCTION

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

(2010) Raphaël Beck et al.   INVESTIGATIONAL NEW DRUGS

Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C

(2010) Marina F. Vita et al.   INVESTIGATIONAL NEW DRUGS

Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols

(2010) Rahul Checker et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor- B Activation

(2010) P. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Antibacterial Effects of Juglone and Its Derivatives against Oral Pathogens

(2010) Ju-Hyun Jeon   Journal of the Korean Society for Applied Biological Chemistry

Plumbagin, Isolated from Plumbago zeylanica, Induces Cell Death through Apoptosis in Human Pancreatic Cancer Cells

(2010) Chien-An Chen et al.   PANCREATOLOGY

Adaptation to Oxidative Stress, Chemoresistance, and Cell Survival

(2009) Matteo Landriscina et al.   ANTIOXIDANTS & REDOX SIGNALING

The anti-leukaemic activity of novel synthetic naphthoquinones against acute myeloid leukaemia: induction of cell death via the triggering of multiple signalling pathways

(2009) Maher Hallak et al.   BRITISH JOURNAL OF HAEMATOLOGY

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

(2009) Tae Gen Son et al.   JOURNAL OF NEUROCHEMISTRY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Chemiluminescence assay for quinones based on generation of reactive oxygen species through the redox cycle of quinone

(2008) Naoya Kishikawa et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Plumbagin, a Medicinal Plant–Derived Naphthoquinone, Is a Novel Inhibitor of the Growth and Invasion of Hormone-Refractory Prostate Cancer

(2008) Moammir H. Aziz et al.   CANCER RESEARCH

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Ethanolic Extract of Juglans regia L. on Blood Sugar in Diabetes-Induced Rats

(2008) Sedigheh Asgary et al.   JOURNAL OF MEDICINAL FOOD

Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting

(2008) W Todd Cade   PHYSICAL THERAPY