Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

Mitochondrial stress and mitokines in aging

(2023) Johannes Burtscher et al.   AGING CELL

Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study

(2023) Vincent L. Aengevaeren et al.   CIRCULATION

Age at Diagnosis of Type 2 Diabetes and Depressive Symptoms, Diabetes-Specific Distress, and Self-Compassion

(2023) Mary M. Barker et al.   DIABETES CARE

Efficacy and Feasibility of Pre-surgical Exercise in Bladder Cancer Patients Scheduled for Open Radical Cystectomy

(2023) Dennis R. Taaffe et al.   MEDICINE & SCIENCE IN SPORTS & EXERCISE

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

(2023) Juliane Cruz Campos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

(2023) Helena A. K. Lapatto et al.   Science Advances

Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process

(2023) Ivo Vieira de Sousa Neto et al.   AGEING RESEARCH REVIEWS

The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy

(2023) Chang Zhang et al.   AGEING RESEARCH REVIEWS

Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch

(2023) Pablo Salmón et al.   AGING CELL

Predictors of Improvement in Exercise Capacity After Cardiac Rehabilitation Differ Between Octogenarian and Young-Old Patients With Acute Myocardial Infarction

(2023) Tatsuo Tokeshi et al.   CIRCULATION JOURNAL

Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease

(2023) Hyunsuk Lee et al.   DIABETES CARE

Best timing for exercise in breast cancer patients initiating chemotherapy: what is the answer?

(2023) Ana Abreu   EUROPEAN HEART JOURNAL

Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial

(2023) Jessica M Scott et al.   EUROPEAN HEART JOURNAL

Lifelong endurance exercise and its relation with coronary atherosclerosis

(2023) Ruben De Bosscher et al.   EUROPEAN HEART JOURNAL

Methylation-Based Biological Age and Hypertension Prevalence and Incidence

(2023) Jacob K. Kresovich et al.   HYPERTENSION

Effect of Age on Hypertension Recognition in Children With Chronic Kidney Disease: A Report From the Chronic Kidney Disease in Children Study

(2023) Chloe E. Douglas et al.   HYPERTENSION

Physical activity and exercise for weight loss and maintenance in people living with obesity

(2023) Jean-Michel Oppert et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

(2023) Nazma Malik et al.   SCIENCE

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

(2023) Jialiu Zeng et al.   Nature Communications

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

(2023) Alexia Blandin et al.   Cell Reports

Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy

(2023) Lijie Ma et al.   Redox Biology

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia

(2023) Emma Nichols et al.   The Lancet Healthy Longevity

AMPK and the Adaptation to Exercise

(2022) Hannah R. Spaulding et al.   Annual Review of Physiology

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

(2022) João A. Amorim et al.   Nature Reviews Endocrinology

MITOCHONDRIAL DYSFUNCTION AND EPIGENETICS UNDERLYING THE LINK BETWEEN EARLY-LIFE NUTRITION AND NON-ALCOHOLIC FATTY LIVER DISEASE

(2022) Anabela La Colla et al.   NUTRITION RESEARCH REVIEWS

TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A

(2022) Jun-Ha Hwang et al.   Nature Communications

Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

(2022) Yoann Combot et al.   Cell Reports

Noncoding RNAs in age-related cardiovascular diseases

(2022) Amela Jusic et al.   AGEING RESEARCH REVIEWS

Autophagy in age-related macular degeneration

(2022) Kai Kaarniranta et al.   Autophagy

Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage

(2022) Samuel T. Orange et al.   INTERNATIONAL JOURNAL OF CANCER

Exerkines in health, resilience and disease

(2022) Lisa S. Chow et al.   Nature Reviews Endocrinology

Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis

(2022) Alex Armstrong et al.   Obesity Reviews

Salivary Proteome, Inflammatory, and NETosis Biomarkers in Older Adult Practitioners and Nonpractitioners of Physical Exercise

(2022) Valeria B. Pacheco et al.   Oxidative Medicine and Cellular Longevity

Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues

(2022) Barbara Arbeithuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis

(2022) Hitomi Yamamoto-Imoto et al.   Cell Reports

Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease

(2022) Aigli-Ioanna Legaki et al.   Current Obesity Reports

Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis

(2022) Sunad Rangarajan et al.   AGING CELL

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

(2022) Cristina López‐Vicario et al.   HEPATOLOGY

Mitigation of age-dependent accumulation of defective mitochondrial genomes

(2022) Pei-I Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning

(2022) Yingqi Zhu et al.   Journal of Advanced Research

Mitochondrial DNA Copy Number: Linking Diabetes and Cancer

(2022) Ashfaque A. Memon et al.   ANTIOXIDANTS & REDOX SIGNALING

An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination

(2022) Danna Sheinboim et al.   CANCER RESEARCH

FGF21–Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity

(2022) Leigang Jin et al.   CIRCULATION

Defining the Specific Skeletal Muscle Adaptations Responsible for Exercise Training Improvements in Heart Failure With Preserved Ejection Fraction

(2022) Wesley J. Tucker et al.   Circulation-Heart Failure

Expression of oxysterols in human lenses: Implications of the sterol pathway in age-related cataracts

(2022) Laura P. Reyes et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Treadmill Exercise Improves PINK1/Parkin-Mediated Mitophagy Activity Against Alzheimer’s Disease Pathologies by Upregulated SIRT1-FOXO1/3 Axis in APP/PS1 Mice

(2022) Na Zhao et al.   MOLECULAR NEUROBIOLOGY

Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease

(2022) Mary Audrey D. Viloria et al.   Frontiers in Cardiovascular Medicine

A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle

(2022) Ronald G. Jones et al.   JOURNAL OF PHYSIOLOGY-LONDON

Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection

(2022) Judy Chen et al.   Nature Communications

Let's get moving: The Global Status Report on Physical Activity 2022 calls for urgent action

(2022) Karen Milton et al.   Journal of Sport and Health Science

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

(2021) Joseph C. Reynolds et al.   Nature Communications

Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer

(2021) Macus Hao-Ran Bao et al.   Cell Reports

Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue

(2021) Pasquale Nigro et al.   DIABETES

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

(2021) Anders B. Klein et al.   Nature Communications

CREG1 improves the capacity of the skeletal muscle response to exercise endurance via modulation of mitophagy

(2021) HaiXu Song et al.   Autophagy

Beneficial intergenerational effects of exercise on brain and cognition: a multilevel meta‐analysis of mean and variance

(2021) Yefeng Yang et al.   BIOLOGICAL REVIEWS

Antihypertrophic Memory after Regression of Exercise-induced Physiological Myocardial Hypertrophy is Mediated by the Long Noncoding RNA Mhrt779

(2021) Hairuo Lin et al.   CIRCULATION

Physical Exercise: A Novel Tool to Protect Mitochondrial Health

(2021) Daniela Sorriento et al.   Frontiers in Physiology

Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis

(2021) Joshua Denham et al.   AGEING RESEARCH REVIEWS

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

(2021) Clair Crewe et al.   Cell Metabolism

Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence‐associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining

(2021) Lei Sun et al.   FASEB JOURNAL

An evidence-based assessment of the impact of the Olympic Games on population levels of physical activity

(2021) Adrian E Bauman et al.   LANCET

Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction

(2021) Dandan Jia et al.   MOLECULAR THERAPY

Mitochondria transported from adipocytes in extracellular vesicles

(2021) Claire Greenhill   Nature Reviews Endocrinology

Extracellular vesicles—incorporated microRNA signature as biomarker and diagnosis of prediabetes state and its complications

(2021) Nicoleta Alexandru et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

(2021) Jianli He et al.   Nature Communications

IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis

(2021) Sandra Sánchez-Sarasúa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle

(2021) Joshua C. Drake et al.   Frontiers in Physiology

Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability

(2021) Miriam Hoene et al.   Molecular Metabolism

Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

(2020) Danielle Hiam et al.   Aging-US

Association of BMI, Fitness, and Mortality in Patients With Diabetes: Evaluating the Obesity Paradox in the Henry Ford Exercise Testing Project (FIT Project) Cohort

(2020) Seamus P. Whelton et al.   DIABETES CARE

Plasma BDNF and TrkB mRNA in PBMCs Are Correlated With Anti-depressive Effects of 12-Weeks Supervised Exercise During Protracted Methamphetamine Abstinence

(2020) Jue Yang et al.   Frontiers in Molecular Neuroscience

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway

(2020) Shibu Marthandam Asokan et al.   Aging-US

Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance

(2020) Hideo Nambu et al.   CARDIOVASCULAR RESEARCH

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

The Effect of a Novel Low-Volume Aerobic Exercise Intervention on Liver Fat in Type 2 Diabetes: A Randomized Controlled Trial

(2020) Angelo Sabag et al.   DIABETES CARE

Diet and exercise in the prevention and treatment of type 2 diabetes mellitus

(2020) Faidon Magkos et al.   Nature Reviews Endocrinology

Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

(2020) Sean L. McGee et al.   Nature Reviews Endocrinology

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter

(2020) Sagnika Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment

(2020) Qiaoyun Wang et al.   Journal of Sport and Health Science

Exercise benefits on Alzheimer’s disease: State-of-the-science

(2020) Pedro L. Valenzuela et al.   AGEING RESEARCH REVIEWS

CD31 Positive-Extracellular Vesicles from Patients with Type 2 Diabetes Shuttle a miRNA Signature Associated with Cardiovascular Complications

(2020) Francesco Prattichizzo et al.   DIABETES

Differential effects of pre‐exercise on cancer cachexia‐induced muscle atrophy in fast‐ and slow‐twitch muscles

(2020) Minoru Tanaka et al.   FASEB JOURNAL

Aging, senescence and mitochondria: the PGC-1/ERR axis

(2020) Vincent Giguere et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease

(2020) Irina Belaya et al.   Journal of Neuroinflammation

Mitochondrial-derived peptides in aging and age-related diseases

(2020) Su-Jeong Kim et al.   GeroScience

Mitochondrial stress and GDF15 in the pathophysiology of sepsis

(2020) Yasunori Fujita et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches

(2020) Jessica F. Hebert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

World Health Organization 2020 guidelines on physical activity and sedentary behaviour

(2020) Fiona C Bull et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function

(2020) Soo Young Kim et al.   CIRCULATION

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy

(2020) Ioannis Kyriazis et al.   CIRCULATION RESEARCH

Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

(2020) Chris E. Shannon et al.   Molecular Metabolism

Fndc5 loss-of-function attenuates exercise-induced browning of white adipose tissue in mice

(2019) Yan Xiong et al.   FASEB JOURNAL

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

(2019) Anupam A. Kumar et al.   CIRCULATION

Deficiency of Mitophagy Receptor FUNDC1 Impairs Mitochondrial Quality and Aggravates Dietary-Induced Obesity and Metabolic Syndrome

(2019) Hao Wu et al.   Autophagy

Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases

(2019) Chengjie Song et al.   AGING CELL

Diabetic Cardiomyopathy

(2019) Wolfgang H. Dillmann   CIRCULATION RESEARCH

Exercise-Induced Mitophagy in Skeletal Muscle and Heart

(2019) Yuntian Guan et al.   EXERCISE AND SPORT SCIENCES REVIEWS

S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocytes Death in Response Ischemic/Reperfusion Injury

(2019) Yulin Li et al.   CIRCULATION

Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling

(2019) Dandan Jia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Physical Activity in Cancer Prevention and Survival

(2019) ANNE MCTIERNAN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation

(2019) Megumi Andoh et al.   Cell Reports

Metabolic remodeling induced by mitokines in heart failure

(2019) Jiahao Duan et al.   Aging-US

The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy

(2019) Liangde Zheng et al.   Autophagy

Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia

(2019) Lianne J. Trigiani et al.   FASEB JOURNAL

Physical training improves exercise tolerance, cardiac function and promotes changes in neurotrophins levels in chagasic mice

(2019) Rafael Leite Alves et al.   LIFE SCIENCES

Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age

(2019) Estelle Balan et al.   Frontiers in Physiology

Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy

(2019) Megan Opichka et al.   CRYOBIOLOGY

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

(2019) Daniel J. Tyrrell et al.   CIRCULATION RESEARCH

Exercise and mitochondrial health

(2019) Jonathan M. Memme et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

(2019) Jelena Stevanović et al.   Molecular Metabolism

Mitochondria and aging: A role for the mitochondrial transition pore?

(2018) Mathieu Panel et al.   AGING CELL

Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

(2018) Pernille Hojman et al.   Cell Metabolism

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats

(2018) Dandan Jia et al.   LIFE SCIENCES

Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders

(2018) CARMEN FIUZA-LUCES et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Exercise-induced ‘browning’ of adipose tissues

(2018) Peter Aldiss et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors

(2018) Carmen Fiuza-Luces et al.   Nature Reviews Cardiology

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

(2018) Stephan Müller et al.   Alzheimers & Dementia

Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria

(2018) Joshua C. Drake et al.   CELL CYCLE

Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury

(2018) Naoya Otaka et al.   CIRCULATION RESEARCH

The Physical Activity Guidelines for Americans

(2018) Katrina L. Piercy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes

(2018) Eduard Peris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

(2018) Toshiro Saito et al.   JOURNAL OF CLINICAL INVESTIGATION

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Redefining Tissue Crosstalk via Shotgun Proteomic Analyses of Plasma Extracellular Vesicles

(2018) Martin Whitham et al.   PROTEOMICS

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

(2018) Hyo Jeong Kim et al.   Cell Death & Disease

High-fat Diet and Physical Exercise Differentially Modulate Adult Neurogenesis in the Mouse Hypothalamus

(2018) C. Klein et al.   NEUROSCIENCE

Preliminary evidence that age and sex affect exercise-induced hTERT expression

(2017) Travis G. Cluckey et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

(2017) Huiqin Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intravenous administration of mitochondria for treating experimental Parkinson's disease

(2017) Xianxun Shi et al.   MITOCHONDRION

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

(2017) Snehal N. Chaudhari et al.   Nature Communications

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

The economic burden of physical inactivity: a global analysis of major non-communicable diseases

(2016) Ding Ding et al.   LANCET

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging

(2015) Justin D. Crane et al.   AGING CELL

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Interleukin-6 gene transfer reverses body weight gain and fatty liver in obese mice

(2015) Yongjie Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance

(2015) Kim Zarse et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial

(2015) Sophie Cassidy et al.   DIABETOLOGIA

ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis

(2015) Li Wang et al.   HEPATOLOGY

IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells

(2015) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice

(2015) Alyssa M. Littlefield et al.   Journal of Neuroinflammation

Fibroblast growth factor-21, energy balance and obesity

(2015) Marta Giralt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Musclin is an activity-stimulated myokine that enhances physical endurance

(2015) Ekaterina Subbotina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism

(2014) Roberto Vettor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Come on BAIBA Light My Fire

(2014) Helene L. Kammoun et al.   Cell Metabolism

Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia, and Exercise Intolerance in Mice with Congestive Heart Failure

(2014) Mitsuharu Okutsu et al.   Circulation-Heart Failure

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Cardiolipin profiles as a potential biomarker of mitochondrial health in diet-induced obese mice subjected to exercise, diet-restriction and ephedrine treatment

(2014) Catherine Faber et al.   JOURNAL OF APPLIED TOXICOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

Association between Physical Activity Advice Only or Structured Exercise Training with Blood Pressure Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

(2014) Franciele R. Figueira et al.   SPORTS MEDICINE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle

(2013) Ayesha Saleem et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study

(2013) Dean Ornish et al.   LANCET ONCOLOGY

Optimizing Intramuscular Adaptations to Aerobic Exercise: Effects of Carbohydrate Restriction and Protein Supplementation on Mitochondrial Biogenesis

(2013) Lee M. Margolis et al.   Advances in Nutrition

Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats

(2012) Rachel B. Speisman et al.   BRAIN BEHAVIOR AND IMMUNITY

Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes

(2012) Edward W. Gregg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression

(2012) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss

(2011) K. Hallsworth et al.   GUT

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms

(2011) Georgina M Ellison et al.   HEART

Physical Activity Advice Only or Structured Exercise Training and Association With HbA1cLevels in Type 2 Diabetes

(2011) Daniel Umpierre   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity

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Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity

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IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

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Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

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Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

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The Second World Cancer Research Fund/American Institute for Cancer Research Expert Report. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective

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ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

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