KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy

Sex-Specific Human Cardiomyocyte Gene Regulation in Left Ventricular Pressure Overload

(2020) Lea Gaignebet et al.   MAYO CLINIC PROCEEDINGS

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

(2020) Yi Tan et al.   Nature Reviews Cardiology

Basic Mechanisms of Diabetic Heart Disease

(2020) Rebecca H. Ritchie et al.   CIRCULATION RESEARCH

Genomic Binding Patterns of Forkhead Box Protein O1 Reveal its Unique Role in Cardiac Hypertrophy

(2020) Jessica Pfleger et al.   CIRCULATION

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

(2019) Dimitra Kokkinaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

High-glucose induces cardiac myocytes apoptosis through Foxo1 /GRK2 signaling pathway

(2019) Ming Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice

(2019) Matthew Hoffman et al.   Journal of the American Heart Association

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

Echocardiographic evaluation of diastolic function in mouse models of heart disease

(2018) Moritz Schnelle et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

(2018) Claudio de Lucia et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide

(2018) Zhongjian Cheng et al.   Redox Biology

Plasmid-normalized quantification of relative mitochondrial DNA copy number

(2018) Federica Fazzini et al.   Scientific Reports

Diabetic cardiomyopathy

(2018) Matthew Meng Yang Lee et al.   HEART

Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting

(2017) Adam J Wilson et al.   HEART

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

(2017) Alyssa Faria et al.   PHARMACOLOGY & THERAPEUTICS

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

(2017) Karthigayan Shanmugasundaram et al.   Nature Communications

Fluorescence quenching of free and bound NADH in HeLa cells determined by hyperspectral imaging and unmixing of cell autofluorescence

(2017) Aziz Ul Rehman et al.   Biomedical Optics Express

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy

(2016) Vidya Kandula et al.   Cardiovascular Diabetology

Assessing Cardiac Metabolism

(2016) Heinrich Taegtmeyer et al.   CIRCULATION RESEARCH

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

(2016) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

(2015) Aleksandr E. Vendrov et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac FunctionNovelty and Significance

(2015) Konstantinos Drosatos et al.   CIRCULATION RESEARCH

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy

(2015) S. M. Tan et al.   FREE RADICAL RESEARCH

Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart

(2015) Romain Harmancey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer

(2015) A. Ruiz de Sabando et al.   MOLECULAR CANCER THERAPEUTICS

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

PPARs: Protectors or Opponents of Myocardial Function?

(2015) Christine J. Pol et al.   PPAR Research

Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

(2015) San-Pin Wu et al.   Nature Communications

Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models

(2014) Camille Marciniak et al.   Cardiovascular Diabetology

Alignment-Annotator web server: rendering and annotating sequence alignments

(2014) Christoph Gille et al.   NUCLEIC ACIDS RESEARCH

Insulin resistance protects the heart from fuel overload in dysregulated metabolic states

(2013) Heinrich Taegtmeyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

(2013) Om P. Mishra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy

(2013) Marina Bayeva et al.   Journal of the American Heart Association

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

(2011) Rita M. Maalouf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic Apolipoprotein E−/− Mice

(2011) Srinivasan Vedantham et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice

(2011) Shin Kumadaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klf5 regulates lineage formation in the pre-implantation mouse embryo

(2010) S.-C. J. Lin et al.   DEVELOPMENT

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

(2010) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

(2009) Ratnadeep Basu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice

(2009) H. Bugger et al.   DIABETES

PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy

(2009) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

(2009) M. T. Coughlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA