The potential of endurance exercise-derived exosomes to treat metabolic diseases

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training

(2016) Mohamed Abu-Farha et al.   PLoS One

Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging

(2015) Justin D. Crane et al.   AGING CELL

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

(2015) Mohamed Abu-Farha et al.   Cardiovascular Diabetology

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

(2015) Nahuel A. Garcia et al.   CARDIOVASCULAR RESEARCH

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Pancreatic Cancer-Associated Diabetes Is an "Exosomopathy"

(2015) M. Korc   CLINICAL CANCER RESEARCH

β-Cell MicroRNAs: Small but Powerful

(2015) Stephen R. Filios et al.   DIABETES

Hepatokines: unlocking the multi-organ network in metabolic diseases

(2015) Alison Iroz et al.   DIABETOLOGIA

Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles

(2015) Susanne Helmig et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Effect of acute exercise on circulating angiogenic cell and microparticle populations

(2015) Kasey A. Lansford et al.   EXPERIMENTAL PHYSIOLOGY

Circulating miR-192 and miR-193b Are Markers of Prediabetes and Are Modulated by an Exercise Intervention

(2015) Marcelina Párrizas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose-brain crosstalk: do adipokines have a role in neuroprotection?

(2015) JonathanP Little et al.   Neural Regeneration Research

Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain

(2015) Joanne Clark-Matott et al.   NEUROBIOLOGY OF AGING

Organizational Update: The World Health Organization Global Status Report on Noncommunicable Diseases 2014; One More Landmark Step in the Combat Against Stroke and Vascular Disease

(2015) S. Mendis et al.   STROKE

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans

(2015) David Patsouris et al.   Cell Reports

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

(2015) Jakob Schiøler Hansen et al.   Molecular Metabolism

Gene and MicroRNA Expression Responses to Exercise; Relationship with Insulin Sensitivity

(2015) Carrie S. McLean et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

MicroRNAs in bovine adipogenesis: genomic context, expression and function

(2014) Josue Romao et al.   BMC GENOMICS

Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease

(2014) Mariëtte EG Kranendonk et al.   Cardiovascular Diabetology

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes

(2014) Naoki Sawada et al.   Cell Metabolism

Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression

(2014) Zhi-Yong Li et al.   CNS Neuroscience & Therapeutics

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

(2014) Hala Aswad et al.   DIABETOLOGIA

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy

(2014) Jenny YY Ooi et al.   Future Medicinal Chemistry

MicroRNAs: the fine modulators of liver development and function

(2014) Yemiao Chen et al.   LIVER INTERNATIONAL

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128

(2014) Yogita K Adlakha et al.   Molecular Cancer

The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training

(2014) Søren Nielsen et al.   PLoS One

Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

(2014) Alexis Forterre et al.   PLoS One

Sprint Interval and Sprint Continuous Training Increases Circulating CD34+ Cells and Cardio-Respiratory Fitness in Young Healthy Women

(2014) Emma Harris et al.   PLoS One

Circulating micrornas as potential biomarkers of aerobic exercise capacity

(2013) Frank C. Mooren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes

(2013) Kinyui Alice Lo et al.   BIOSCIENCE REPORTS

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Betatrophin Fuels β Cell Proliferation: First Step toward Regenerative Therapy?

(2013) Heiko Lickert   Cell Metabolism

MicroRNA Regulation and Role in Stem Cell Maintenance, Cardiac Differentiation and Hypertrophy

(2013) K.T. Kuppusamy et al.   CURRENT MOLECULAR MEDICINE

Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice

(2013) M. J. Rahman et al.   DIABETES

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Developmental expression and evolution of muscle-specific microRNAs conserved in vertebrates

(2013) Saori Tani et al.   EVOLUTION & DEVELOPMENT

Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: the RESOLVE* randomized trial

(2013) Frédéric Dutheil et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Epigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction

(2013) Esther Barreiro et al.   JOURNAL OF APPLIED PHYSIOLOGY

Skeletal Muscle-derived Myonectin Activates the Mammalian Target of Rapamycin (mTOR) Pathway to Suppress Autophagy in Liver

(2013) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women

(2013) Michaela C. Devries et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation

(2013) A. Aucher et al.   JOURNAL OF IMMUNOLOGY

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

(2013) Aaron P. Russell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis

(2013) Irene Zubiri et al.   Journal of Proteomics

Exercise-Induced Insulin-Like Growth Factor I System Concentrations after Training in Women

(2013) SARA M. GREGORY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

Cell-cell communication via extracellular membrane vesicles and its role in the immune response

(2013) Inkyu Hwang   MOLECULES AND CELLS

Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

(2013) Imtiaz A. Samjoo et al.   PLoS One

Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

(2013) Federica Barutta et al.   PLoS One

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rapidly evolving revolution in stem cell biology and medicine

(2013) Alan Trounson   REPRODUCTIVE BIOMEDICINE ONLINE

The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men

(2013) I A Samjoo et al.   Nutrition & Diabetes

The genetic component of Brugada syndrome

(2013) Morten W. Nielsen et al.   Frontiers in Physiology

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

(2013) Keitaro Hagiwara et al.   Drug Delivery and Translational Research

Exosomes in Prostate Cancer: Putting Together the Pieces of a Puzzle

(2013) Carolina Soekmadji et al.   Cancers

Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training

(2012) Sandra J. Peters et al.   Applied Physiology Nutrition and Metabolism

Effect of exercise training on diastolic function in metabolic syndrome

(2012) Sophie Lalande et al.   Applied Physiology Nutrition and Metabolism

Endurance exercise in a rat model of metabolic syndrome

(2012) Isabelle Cameron et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Effects of Exercise on microRNA Expression in Young Males Peripheral Blood Mononuclear Cells

(2012) Shlomit Radom-Aizik et al.   CTS-Clinical and Translational Science

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Changing Physical Activity Behavior in Type 2 Diabetes: A systematic review and meta-analysis of behavioral interventions

(2012) L. Avery et al.   DIABETES CARE

Diabetes and Physical Activity

(2012)   DIABETES EDUCATOR

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

(2012) Brooke L. Deatherage et al.   INFECTION AND IMMUNITY

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mtDNA Migration and the Role of Exosomes in Horizontal Gene Transfer

(2012) Y. Esquilin et al.   MICROSCOPY AND MICROANALYSIS

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Mediterranean diet, moderate-to-high intensity training, and health-related quality of life in adults with metabolic syndrome

(2012) L Landaeta-Díaz et al.   European Journal of Preventive Cardiology

Muscle-to-organ cross talk mediated by myokines

(2012) Line Pedersen et al.   Adipocyte

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle

(2011) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis

(2011) Jonathan P. Little et al.   Applied Physiology Nutrition and Metabolism

Exosomes From Human CD34 + Stem Cells Mediate Their Proangiogenic Paracrine Activity

(2011) Susmita Sahoo et al.   CIRCULATION RESEARCH

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Modulation of MicroRNAs During Exercise and Disease in Human Skeletal Muscle

(2011) James A. Timmons   EXERCISE AND SPORT SCIENCES REVIEWS

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity

(2010) Wataru Aoi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults

(2010) Darren ER Warburton et al.   International Journal of Behavioral Nutrition and Physical Activity

Non-vigorous physical activity and all-cause mortality: systematic review and meta-analysis of cohort studies

(2010) J. Woodcock et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle

(2010) Søren Nielsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins

(2010) J. Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Exercise Performance by Hemodialysis Patients: A Review of the Literature

(2010) Ingrid Brenner   PHYSICIAN AND SPORTSMEDICINE

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

(2009) Vladimir B. Ritov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physical Activity, Function, and Longevity Among the Very Old

(2009) Jochanan Stessman   ARCHIVES OF INTERNAL MEDICINE

Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity?

(2009) Dominique Langin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Physical Activity and Prevention of Cardiovascular Disease in Older Adults

(2009) David M. Buchner   CLINICS IN GERIATRIC MEDICINE

Mitochondrial vesicles: an ancient process providing new links to peroxisomes

(2009) Miguel A Andrade-Navarro et al.   CURRENT OPINION IN CELL BIOLOGY

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

(2009) A. Granjon et al.   DIABETES

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Physical activity, obesity and risk for esophageal adenocarcinoma

(2009) Lloyd Balbuena et al.   Future Oncology

Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines

(2009) Bente K. Pedersen   JOURNAL OF APPLIED PHYSIOLOGY

Exercise and adrenaline increase PGC-1α mRNA expression in rat adipose tissue

(2009) Lindsey N. Sutherland et al.   JOURNAL OF PHYSIOLOGY-LONDON

The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk

(2009) Bente K. Pedersen   JOURNAL OF PHYSIOLOGY-LONDON

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

(2009)   LANCET

miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice

(2009) Adeel Safdar et al.   PLoS One

Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles

(2009) Eun-Young Lee et al.   PROTEOMICS

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Reduced Disability and Mortality Among Aging Runners

(2008) Eliza F. Chakravarty   ARCHIVES OF INTERNAL MEDICINE

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components

(2008) Albert F. Ellen et al.   EXTREMOPHILES

Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women

(2008) Michaela C. Devries et al.   FREE RADICAL BIOLOGY AND MEDICINE

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE

Systemic and mitochondrial adaptive responses to moderate exercise in rodents

(2007) Alberto Boveris et al.   FREE RADICAL BIOLOGY AND MEDICINE