Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

(2021) Kiran Todkar et al.   Nature Communications

Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice

(2020) Lu Gan et al.   CIRCULATION

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

(2020) Jonathan R. Brestoff et al.   Cell Metabolism

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

(2019) Yong Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis

(2019) Salvatore Antonucci et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

(2019) Su Chul Jang et al.   Journal of Extracellular Vesicles

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

(2019) Thomas Senoner et al.   Nutrients

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

(2019) Christine M. Kusminski et al.   DIABETES

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular Vesicles from Hypoxic Adipocytes and Obese Subjects Reduce Insulin-Stimulated Glucose Uptake

(2018) Justyna Mleczko et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling

(2018) Carly S. Cox et al.   Cell Metabolism

The role of adipose tissue in cardiovascular health and disease

(2018) Evangelos K. Oikonomou et al.   Nature Reviews Cardiology

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Management of cardiovascular diseases in patients with obesity

(2017) Carl J. Lavie et al.   Nature Reviews Cardiology

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

(2017) Yuan Wan et al.   Nature Biomedical Engineering

A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles

(2017) Henar Suárez et al.   Scientific Reports

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences

(2016) Afshan N. Malik et al.   MITOCHONDRION

Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

(2016) F. Edland et al.   Nutrition & Metabolism

Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells

(2016) Roya Kalantari et al.   RNA

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion

(2015) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease

(2015) Ingrid EM Bank et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

High-performance probes for light and electron microscopy

(2015) Sarada Viswanathan et al.   NATURE METHODS

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status

(2015) Theresa Schöttl et al.   Molecular Metabolism

High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury

(2014) Ruduwaan Salie et al.   Cardiovascular Diabetology

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease

(2014) Emily S. Koeck et al.   JOURNAL OF SURGICAL RESEARCH

Obesity and Cardiovascular Diseases

(2014) Carl J. Lavie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease

(2014) Sarah C. Ferrante et al.   PEDIATRIC RESEARCH

Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning

(2013) Cevher Ozcan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Biphasic Response of Mitochondrial Biogenesis to Oxidative Stress in Visceral Fat of Diet-Induced Obesity Mice

(2013) Pei-Wen Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages

(2013) Mariëtte E.G. Kranendonk et al.   Obesity

Myocardial Infarction and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome

(2013) Mette Thomsen et al.   JAMA Internal Medicine

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

(2012) John R. Ussher et al.   CARDIOVASCULAR RESEARCH

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

(2012) Helena M Cochemé et al.   Nature Protocols

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

(2010) J. M. Curtis et al.   DIABETES

Identification and Characterization of a Promoter Cassette Conferring Adipocyte-Specific Gene Expression

(2010) Zhao V. Wang et al.   ENDOCRINOLOGY

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

(2009) Z.-b. Deng et al.   DIABETES

Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity

(2008) Eugene F. du Toit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

(2008) Pamela Fischer-Posovszky et al.   Obesity Facts