Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy

(2017) Rebecca J. Wilson et al.   MITOCHONDRION

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity

(2016) Jonathan M. Memme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

Exercise Promotes Healthy Aging of Skeletal Muscle

(2016) Gregory D. Cartee et al.   Cell Metabolism

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy

(2016) Mengqi Lv et al.   Protein & Cell

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

(2015) Prashant Mishra et al.   Cell Metabolism

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

(2015) Alban Ordureau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A NovelMitoTimerReporter Gene for Mitochondrial Content, Structure, Stress, and Damagein Vivo

(2014) Rhianna C. Laker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

(2013) E.P. Taddeo et al.   Molecular Metabolism

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

(2010) Anson Pierce et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA