Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

(2021) Anthony Ravussin et al.   JOURNAL OF CELL SCIENCE

Coordinate regulation of the senescent state by selective autophagy

(2021) Yeonghyeon Lee et al.   DEVELOPMENTAL CELL

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

(2020) Niklas Mejhert et al.   MOLECULAR CELL

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

The Role of Hydrogen Peroxide and Peroxiredoxins throughout the Cell Cycle

(2020) Sukyeong Heo et al.   Antioxidants

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Independent regulation of age associated fat accumulation and longevity

(2020) Anthony O. Beas et al.   Nature Communications

ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy

(2020) Piotr Sunderland et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

(2020) Tadashi Yamamuro et al.   Nature Communications

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

(2020) Meltem Weger et al.   eLife

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Suppression of autophagic activity by Rubicon is a signature of aging

(2019) Shuhei Nakamura et al.   Nature Communications

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

(2019) Blake R Wilde et al.   eLife

HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress

(2019) Je-Jung Lee et al.   FASEB JOURNAL

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion

(2019) Junhua Zhang et al.   JOURNAL OF BIOCHEMISTRY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

(2018) Joon Tae Park et al.   AGEING RESEARCH REVIEWS

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition

(2018) Baoyuan Zhang et al.   ONCOGENE

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data

(2018) Shinya Oki et al.   EMBO REPORTS

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

(2018) Bochra Zidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells

(2017) Quentin Verdon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling

(2016) Byungyong Ahn et al.   JOURNAL OF CLINICAL INVESTIGATION

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Roles for ROS and hydrogen sulfide in the longevity response to germline loss inCaenorhabditis elegans

(2016) Yuehua Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

(2016) Shuhei Nakamura et al.   Nature Communications

Downregulation of peroxiredoxin-3 by hydrophobic bile acid induces mitochondrial dysfunction and cellular senescence in human trophoblasts

(2016) Wei-Bin Wu et al.   Scientific Reports

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

MondoA-Mlx Transcriptional Activity Is Limited by mTOR-MondoA Interaction

(2014) Mohan R. Kaadige et al.   MOLECULAR AND CELLULAR BIOLOGY

The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals

(2014) David W. Johnson et al.   PLoS Genetics

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells

(2014) Brian Cunniff et al.   Redox Biology

The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults

(2013) Andrew D. Rule   ANNALS OF INTERNAL MEDICINE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation

(2013) Uwe Richter et al.   CURRENT BIOLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

(2010) Thomas Landes et al.   EMBO REPORTS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer

(2010) C. W. Peterson et al.   MOLECULAR AND CELLULAR BIOLOGY

Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

(2010) Julia Ling-Yu Chen et al.   PLoS Genetics

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of mitochondrial H2O2by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

(2008) Liuji Chen et al.   AGING CELL

Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

(2008) C. A. Stoltzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA