Mitochondrial stress and GDF15 in the pathophysiology of sepsis

Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury

(2020) Jing Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

Mitochondrial Functions in Infection and Immunity

(2020) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Serine Catabolism Feeds NADH when Respiration Is Impaired

(2020) Lifeng Yang et al.   Cell Metabolism

GDF15: A hormone conveying somatic distress to the brain

(2020) Samuel M Lockhart et al.   ENDOCRINE REVIEWS

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis

(2020) Isa Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

(2020) Gudrun Meinhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

(2020) Eran Mick et al.   eLife

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

(2020) Arpit Katiyar et al.   FEBS Open Bio

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

(2020) Ji Sun Moon et al.   AGING CELL

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

(2020) Rowena Suriben et al.   NATURE MEDICINE

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

(2020) Leiluo Geng et al.   Nature Reviews Endocrinology

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes

(2019) Ehtesham Arif et al.   KIDNEY INTERNATIONAL

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS

(2019) Vicky Wang-Wei Tsai et al.   INTERNATIONAL JOURNAL OF OBESITY

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

(2019) Yves T. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia

(2019) Tamara Antonela Vico et al.   BASIC RESEARCH IN CARDIOLOGY

Heme-regulated eIF2alpha kinase in erythropoiesis and hemoglobinopthies

(2019) Jane-Jane Chen et al.   BLOOD

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury

(2019) Masoud Hassanpour Golakani et al.   JOURNAL OF NEUROTRAUMA

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice

(2018) Ding Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis

(2018) Mohammed Benkheil et al.   BIOCHEMICAL PHARMACOLOGY

YAP promotes breast cancer metastasis by repressing growth differentiation factor-15

(2018) Ting Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation

(2018) Chenhui Zhao et al.   ONCOGENE

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6

(2018) Jing Jing Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

(2017) Nivedita M. Ratnam et al.   JOURNAL OF CLINICAL INVESTIGATION

Growth Differentiation Factor–15 and Risk of CKD Progression

(2017) Viji Nair et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro : Role of Hif-1α

(2017) Yuhao Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

(2017) Palida Abulizi et al.   Scientific Reports

GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury

(2017) Hyo Kyun Chung et al.   Scientific Reports

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

(2016) Yasunori Fujita et al.   Geriatrics & Gerontology International

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Function in Sepsis

(2016) Nishkantha Arulkumaran et al.   SHOCK

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

(2015) Yasunori Fujita et al.   MITOCHONDRION

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

(2015) K-W Min et al.   ONCOGENE

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery

(2014) Virginia Vanasco et al.   FREE RADICAL BIOLOGY AND MEDICINE

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Maturation of Growth Differentiation Factor 15 in Human Placental Trophoblast Cells Depends on the Interaction With Matrix Metalloproteinase-26

(2014) Sisi Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria

(2014) Pierre Eyenga et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

A promoter-level mammalian expression atlas

(2014)   NATURE

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+

(2014) A K Krug et al.   Cell Death & Disease

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

(2013) Kook Hwan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation and effects of GDF-15 in the retina following optic nerve crush

(2013) Petar Charalambous et al.   CELL AND TISSUE RESEARCH

Change in Growth Differentiation Factor 15 Concentrations over Time Independently Predicts Mortality in Community-Dwelling Elderly Individuals

(2013) K. M. Eggers et al.   CLINICAL CHEMISTRY

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

Growth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response

(2013) Zhizhong Zhou et al.   PLoS One

Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations

(2012) Kenjiro Kami et al.   MITOCHONDRION

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults

(2011) Lori B. Daniels et al.   CIRCULATION

Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

(2011) Eva Rath et al.   GUT

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

The Effects of Sepsis on Mitochondria

(2011) Glòria Garrabou et al.   JOURNAL OF INFECTIOUS DISEASES

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

Growth Differentiation Factor 15 Is Induced by Hepatitis C Virus Infection and Regulates Hepatocellular Carcinoma-Related Genes

(2011) Youhui Si et al.   PLoS One

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP  and ATF3

(2010) S. H. Lee et al.   CARCINOGENESIS

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

(2010) P. Roth et al.   CLINICAL CANCER RESEARCH

Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma

(2010) K. Soucek et al.   HUMAN REPRODUCTION

The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores

(2010) Asne R. Bauskin et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

(2009) Jillian M. Silva et al.   NEUROBIOLOGY OF DISEASE

Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1/GDF15) Expression Is Increased by the Histone Deacetylase Inhibitor Trichostatin A

(2008) Hiroki Yoshioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY