The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals

(2014) Yu-Cheng Lin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver

(2014) Rafaela Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice

(2013) Anouk Funke et al.   ATHEROSCLEROSIS

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Long-Lasting Improvements in Liver Fat and Metabolism Despite Body Weight Regain After Dietary Weight Loss

(2013) S. Haufe et al.   DIABETES CARE

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

Hepatocyte-specificPtpn6deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ

(2013) Elaine Xu et al.   HEPATOLOGY

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

(2013) Sander M. Houten et al.   HUMAN MOLECULAR GENETICS

Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

(2013) Mark M Smits et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Leptin ameliorates insulin resistance and hepatic steatosis inAgpat2−/−lipodystrophic mice independent of hepatocyte leptin receptors

(2013) Víctor A. Cortés et al.   JOURNAL OF LIPID RESEARCH

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

(2013) Douglas E Befroy et al.   NATURE MEDICINE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

A gene variant ofPNPLA3, but not ofAPOC3, is associated with histological parameters of NAFLD in an obese population

(2013) A. Verrijken et al.   Obesity

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

(2013) J. L. Cantley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

(2012) Hong Yu Wang et al.   BIOCHEMICAL JOURNAL

Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA

(2012) Abdussalam Adina-Zada et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

(2012) Robert V. Farese et al.   Cell Metabolism

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

(2012) C. Flannery et al.   DIABETES

Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans

(2012) B. C. Bergman et al.   DIABETOLOGIA

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

(2012) Naoki Kumashiro et al.   HEPATOLOGY

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

Opuntia ficus indica (Nopal) Attenuates Hepatic Steatosis and Oxidative Stress in Obese Zucker (fa/fa) Rats

(2012) Sofía Morán-Ramos et al.   JOURNAL OF NUTRITION

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

(2012) W. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

(2012) K. F. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

(2012) Cheng Zhang et al.   TOXICOLOGY LETTERS

Dissociating fatty liver and diabetes

(2012) Zheng Sun et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA

(2011) Abdussalam Adina-Zada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis

(2011) Lorissa J. Niebergall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

(2011) Andreas L. Birkenfeld et al.   Cell Metabolism

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes

(2011) A. I. Schmid et al.   DIABETES CARE

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

(2011) E. L. Lim et al.   DIABETOLOGIA

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

(2011) K. Raddatz et al.   DIABETOLOGIA

Thyroid Hormone Receptor-α Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance

(2011) François R. Jornayvaz et al.   ENDOCRINOLOGY

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

(2011) Michael R. Charlton et al.   GASTROENTEROLOGY

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

(2011) Hui-Young Lee et al.   HEPATOLOGY

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content

(2011) A Peter et al.   INTERNATIONAL JOURNAL OF OBESITY

Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

(2011) Sheetal Gandotra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

(2011) R. Rabol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

(2011) F. R. Jornayvaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

(2010) François R. Jornayvaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

(2010) Julia Kozlitina et al.   HEPATOLOGY

Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease

(2010) Kausik Das et al.   HEPATOLOGY

A Promoter Polymorphism in the Liver-specific Fatty Acid Transport Protein 5 is Associated with Features of the Metabolic Syndrome and Steatosis

(2010) A. Auinger et al.   HORMONE AND METABOLIC RESEARCH

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model

(2010) Nobuyasu Shindo et al.   JOURNAL OF HEPATOLOGY

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

(2010) J. Mark Brown et al.   JOURNAL OF LIPID RESEARCH

Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

(2010) Kitt Falk Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

(2009) Jose Antonio Chavez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

(2009) Yoshio Nagai et al.   Cell Metabolism

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

(2009) Kathy Jaworski et al.   NATURE MEDICINE

Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women

(2009) Bettina Mittendorfer et al.   Obesity

Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice

(2008) Neel S. Singhal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

TheDGAT2gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

(2008) Konstantinos Kantartzis et al.   CLINICAL SCIENCE

Silencing of Hepatic Fatty Acid Transporter Protein 5in VivoReverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

(2008) Holger Doege et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2

(2008) Stefan Hanke et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased Expression and Activity of Hepatic Lipase in the Liver of Morbidly Obese Adult Patients in Relation to Lipid Content

(2008) Eva Pardina et al.   OBESITY SURGERY