Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
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Title
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
Authors
Keywords
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Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-04-27
DOI
10.1038/s41580-023-00604-z
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Note: Only part of the references are listed.- The variant rs77559646 associated with aggressive prostate cancer disrupts ANO7 mRNA splicing and protein expression
- (2022) Gudrun Wahlström et al. HUMAN MOLECULAR GENETICS
- Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
- (2022) Wanyan Deng et al. NATURE
- Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells
- (2022) Yuta Ryoden et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene
- (2022) Justin A. Pater et al. HUMAN GENETICS
- Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine
- (2022) Chihiro Kurematsu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inefficient development of syncytiotrophoblasts in the Atp11a -deficient mouse placenta
- (2022) Yuki Ochiai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding
- (2022) Meng-Ting Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TMEM16 scramblases thin the membrane to enable lipid scrambling
- (2022) Maria E. Falzone et al. Nature Communications
- Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
- (2022) Thibaud Dieudonné et al. eLife
- Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
- (2022) Nanaka Kaneshiro et al. iScience
- Interaction between VPS13A and the XK scramblase is important for VPS13A function in humans
- (2022) Jae-Sook Park et al. JOURNAL OF CELL SCIENCE
- Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications
- (2022) Zsuzsa Szondy et al. Journal of Cachexia Sarcopenia and Muscle
- Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing
- (2022) Angela Ballesteros et al. Science Advances
- The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP‐induced cell death
- (2022) Yuta Ryoden et al. BIOESSAYS
- Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes
- (2022) Yugo Miyata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of the TMC-1 complex illuminate mechanosensory transduction
- (2022) Hanbin Jeong et al. NATURE
- A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane
- (2022) Andrés Guillén-Samander et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of microglia-mediated synapse turnover and synaptogenesis
- (2022) Jayson B. Ball et al. PROGRESS IN NEUROBIOLOGY
- The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
- (2022) George Khelashvili et al. Communications Biology
- Impact of the Human Cell Atlas on medicine
- (2022) Jennifer E. Rood et al. NATURE MEDICINE
- ANO5 ensures trafficking of annexins in wounded myofibers
- (2021) Steven J. Foltz et al. JOURNAL OF CELL BIOLOGY
- Flagging fusion: Phosphatidylserine signaling in cell-cell fusion
- (2021) Jarred M. Whitlock et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Annexins and Membrane Repair Dysfunctions in Muscular Dystrophies
- (2021) Coralie Croissant et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction
- (2021) Valeria Kalienkova et al. JOURNAL OF MOLECULAR BIOLOGY
- How Do Red Blood Cells Die?
- (2021) Perumal Thiagarajan et al. Frontiers in Physiology
- The Fertilization Enigma: How Sperm and Egg Fuse
- (2021) Victoria E. Deneke et al. Annual Review of Cell and Developmental Biology
- Biallelic truncating variants in ATP9A cause a novel neurodevelopmental disorder involving postnatal microcephaly and failure to thrive
- (2021) Guido Vogt et al. JOURNAL OF MEDICAL GENETICS
- Structural Basis of Substrate-Independent Phosphorylation in a P4-ATPase Lipid Flippase
- (2021) Milena Timcenko et al. JOURNAL OF MOLECULAR BIOLOGY
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- TMEM16F and dynamins control expansive plasma membrane reservoirs
- (2021) Christine Deisl et al. Nature Communications
- Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling
- (2021) Monique S Straub et al. eLife
- Phospholipid‐flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure
- (2021) Tao Li et al. EMBO JOURNAL
- CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts
- (2021) Marta Grifell-Junyent et al. JOURNAL OF CELL SCIENCE
- The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes
- (2021) Takaharu Sakuragi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of the P4B ATPase lipid flippase activity
- (2021) Lin Bai et al. Nature Communications
- Biallelic truncation variants in ATP9A are associated with a novel autosomal recessive neurodevelopmental disorder
- (2021) Francesca Mattioli et al. npj Genomic Medicine
- TMEM16E/ANO5 Mutations related to Bone Dysplasia or Muscular Dystrophy cause Opposite Effects on Lipid Scrambling
- (2020) Eleonora Di Zanni et al. HUMAN MUTATION
- Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation
- (2020) Ning Wu et al. Cell Reports
- Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export
- (2020) Shaun Martin et al. ACTA NEUROPATHOLOGICA
- A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
- (2020) Tao Li et al. EMBO JOURNAL
- Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape
- (2020) J. H. Lorent et al. Nature Chemical Biology
- Structures of a P4-ATPase lipid flippase in lipid bilayers
- (2020) Yilin He et al. Protein & Cell
- ATP10B and the risk for Parkinson’s disease
- (2020) Raquel Real et al. ACTA NEUROPATHOLOGICA
- Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
- (2020) Nicole Scott‐Hewitt et al. EMBO JOURNAL
- Crystal structure of a human plasma membrane phospholipid flippase
- (2020) Hanayo Nakanishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization
- (2020) Sayuri Okamoto et al. MOLECULAR BIOLOGY OF THE CELL
- TMEM16K is an interorganelle regulator of endosomal sorting
- (2020) Maja Petkovic et al. Nature Communications
- Physiological roles of transverse lipid asymmetry of animal membranes
- (2020) R.J. Clarke et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Antibody to CD137 activated by extracellular adenosine triphosphate is tumor selective and broadly effective in vivo without systemic immune activation
- (2020) Mika Kamata-Sakurai et al. Cancer Discovery
- Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM
- (2020) Hanayo Nakanishi et al. Cell Reports
- Structural and functional consequences of reversible lipid asymmetry in living membranes
- (2020) Milka Doktorova et al. Nature Chemical Biology
- Transport mechanism of P4 ATPase phosphatidylcholine flippases
- (2020) Lin Bai et al. eLife
- Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase
- (2019) Maria E Falzone et al. eLife
- Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure
- (2019) Takaharu Sakuragi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells
- (2019) Angela Y. Liou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evolution and a revised nomenclature of P4 ATPases, a eukaryotic family of lipid flippases
- (2019) Michael Palmgren et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- An inner activation gate controls TMEM16F phospholipid scrambling
- (2019) Trieu Le et al. Nature Communications
- Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F
- (2019) Carolina Alvadia et al. eLife
- Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
- (2019) Valeria Kalienkova et al. eLife
- Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals
- (2019) Nashaiman Pervaiz et al. BMC EVOLUTIONARY BIOLOGY
- Structure and autoregulation of a P4-ATPase lipid flippase
- (2019) Milena Timcenko et al. NATURE
- Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating
- (2019) Koustav Maity et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution
- (2019) Takuma Tsuji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
- (2019) Shengjie Feng et al. Cell Reports
- Ligand Binding and Signaling of HARE/Stabilin-2
- (2019) Edward N. Harris et al. Biomolecules
- Phospholipid flippases in membrane remodeling and transport carrier biogenesis
- (2019) Jordan T Best et al. CURRENT OPINION IN CELL BIOLOGY
- Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
- (2019) Masahiro Hiraizumi et al. SCIENCE
- Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins
- (2019) George Khelashvili et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- ATP8A2-related disorders as recessive cerebellar ataxia
- (2019) Claire Guissart et al. JOURNAL OF NEUROLOGY
- Infertility caused by inefficient apoptotic germ cell clearance in Xkr8-deficient male mice
- (2019) Yahiro Yamashita et al. MOLECULAR AND CELLULAR BIOLOGY
- Gene of the issue: ANO6 and Scott Syndrome
- (2019) Sarah L. Millington-Burgess et al. PLATELETS
- Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
- (2019) Claudia M. Rival et al. Nature Communications
- The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K
- (2019) Simon R. Bushell et al. Nature Communications
- Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
- (2019) Lin Bai et al. Nature Communications
- Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure
- (2019) Xinyu Yang et al. IMMUNITY
- Cell Fusion: Merging Membranes and Making Muscle
- (2019) Michael J. Petrany et al. TRENDS IN CELL BIOLOGY
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Transbilayer lipid asymmetry
- (2018) Toshihide Kobayashi et al. CURRENT BIOLOGY
- Necroptosis in development and diseases
- (2018) Bing Shan et al. GENES & DEVELOPMENT
- Phospholipid subcellular localization and dynamics
- (2018) Yanbo Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Common signalling pathways in macrophage and osteoclast multinucleation
- (2018) Marie Pereira et al. JOURNAL OF CELL SCIENCE
- Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy
- (2018) Hugh J. McMillan et al. Orphanet Journal of Rare Diseases
- Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase
- (2018) Mahiru Kawano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single-molecule analysis of phospholipid scrambling by TMEM16F
- (2018) Rikiya Watanabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases
- (2018) Mattia Malvezzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations
- (2018) Tingting Sui et al. Cell Death & Disease
- Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
- (2018) Masaki Tsuchiya et al. Nature Communications
- VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
- (2018) Nikit Kumar et al. JOURNAL OF CELL BIOLOGY
- TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
- (2018) Bifeng Pan et al. NEURON
- New Insights into the Molecular Events of Mammalian Fertilization
- (2018) Yuhkoh Satouh et al. TRENDS IN BIOCHEMICAL SCIENCES
- Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
- (2018) Byoung-Cheol Lee et al. Nature Communications
- Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration
- (2018) Naoki Hisamoto et al. Nature Communications
- Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues
- (2018) Jiao Wang et al. Scientific Reports
- Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila
- (2018) Maria L. Sapar et al. Cell Reports
- Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins
- (2018) Angela Ballesteros et al. eLife
- Avidity‐driven polarity establishment via multivalent lipid–GTPase module interactions
- (2018) Julien Meca et al. EMBO JOURNAL
- Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)
- (2018) Hye-Won Shin et al. FASEB JOURNAL
- Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution
- (2018) Jonathan D. Proto et al. IMMUNITY
- Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs
- (2018) Bartholomew P Roland et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DEL-1 promotes macrophage efferocytosis and clearance of inflammation
- (2018) Ioannis Kourtzelis et al. NATURE IMMUNOLOGY
- Phospholipid flippases enable precursor B cells to flee engulfment by macrophages
- (2018) Katsumori Segawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
- (2018) Sebastian Rühl et al. SCIENCE
- Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
- (2018) Xin Liu et al. Nature Communications
- Cryo-EM structure of the mechanically activated ion channel OSCA1.2
- (2018) Sebastian Jojoa-Cruz et al. eLife
- The P2X7 Receptor in Infection and Inflammation
- (2017) Francesco Di Virgilio et al. IMMUNITY
- Cell-surface phosphatidylserine regulates osteoclast precursor fusion
- (2017) Santosh K. Verma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Scaling single-cell genomics from phenomenology to mechanism
- (2017) Amos Tanay et al. NATURE
- Lipidomic and metabolic changes in the P4-type ATPase ATP10D deficient C57BL/6J wild type mice upon rescue of ATP10D function
- (2017) Alexander Sigruener et al. PLoS One
- Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis
- (2017) Yuichi Yanagihashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of the scrambling domain of the TMEM16 family
- (2017) Sayuri Gyobu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase
- (2017) Tao Jiang et al. eLife
- Role of Ca2+ in the Stability and Function of TMEM16F and 16K
- (2016) Kenji Ishihara et al. BIOCHEMISTRY
- A new mutation of ANO 6 in two familial cases of Scott syndrome
- (2016) Pierre Boisseau et al. BRITISH JOURNAL OF HAEMATOLOGY
- Exposure of phosphatidylserine on the cell surface
- (2016) S Nagata et al. CELL DEATH AND DIFFERENTIATION
- ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia
- (2016) N. Arashiki et al. HAEMATOLOGICA
- Defective membrane fusion and repair inAnoctamin5-deficient muscular dystrophy
- (2016) Danielle A. Griffin et al. HUMAN MOLECULAR GENETICS
- Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion
- (2016) Yu Hu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Chaperoning SNARE assembly and disassembly
- (2016) Richard W. Baker et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane
- (2016) Edouard M. Bevers et al. PHYSIOLOGICAL REVIEWS
- Surface Phosphatidylserine Is Responsible for the Internalization on Microvesicles Derived from Hypoxia-Induced Human Bone Marrow Mesenchymal Stem Cells into Human Endothelial Cells
- (2016) Xiaojuan Wei et al. PLoS One
- Atomistic insight into lipid translocation by a TMEM16 scramblase
- (2016) Neville P. Bethel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure
- (2016) Jun Suzuki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct observation of proton pumping by a eukaryotic P-type ATPase
- (2016) S. Veshaguri et al. SCIENCE
- Microglia: Architects of the Developing Nervous System
- (2016) Jeffrey L. Frost et al. TRENDS IN CELL BIOLOGY
- Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair
- (2016) Volker Middel et al. Nature Communications
- Phosphatidylserine exposure is required for ADAM17 sheddase function
- (2016) Anselm Sommer et al. Nature Communications
- ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia
- (2016) N. Arashiki et al. HAEMATOLOGICA
- A novel affinity-based method for the isolation of highly purified extracellular vesicles
- (2016) Wataru Nakai et al. Scientific Reports
- Secretory sphingomyelinase in health and disease
- (2015) Johannes Kornhuber et al. BIOLOGICAL CHEMISTRY
- A Primer to Single-Particle Cryo-Electron Microscopy
- (2015) Yifan Cheng et al. CELL
- Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase
- (2015) S. Lee et al. EMBO JOURNAL
- Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium
- (2015) Katsumori Segawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics
- (2015) Tomoki Naito et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
- (2015) Paolo Scudieri et al. JOURNAL OF PHYSIOLOGY-LONDON
- ATMEM16Fpoint mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling
- (2015) M. B. Brooks et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility
- (2015) Sayuri Gyobu et al. MOLECULAR AND CELLULAR BIOLOGY
- EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway
- (2015) Brent Neumann et al. NATURE
- Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations
- (2015) Marco Savarese et al. NEUROMUSCULAR DISORDERS
- Review: An overview of molecular events occurring in human trophoblast fusion
- (2015) P. Gerbaud et al. PLACENTA
- TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets
- (2015) Toshihiro Fujii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts
- (2015) J. Chung et al. SCIENCE
- Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling
- (2015) Y. Zhou et al. SCIENCE
- Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
- (2015) Sarah E. Headland et al. Science Translational Medicine
- An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
- (2015) Katsumori Segawa et al. TRENDS IN CELL BIOLOGY
- Identification and characterization of ANO9 in stage II and III colorectal carcinoma
- (2015) Chunxiang Li et al. Oncotarget
- Identification of a lipid scrambling domain in ANO6/TMEM16F
- (2015) Kuai Yu et al. eLife
- Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy
- (2015) Jing Xu et al. Skeletal Muscle
- Giant Axon Formation in Mice Lacking Kell, XK, or Kell and XK
- (2014) Xiang Zhu et al. AMERICAN JOURNAL OF PATHOLOGY
- MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands
- (2014) S. Toda et al. BLOOD
- Mice Deficient in the Putative Phospholipid Flippase ATP11C Exhibit Altered Erythrocyte Shape, Anemia, and Reduced Erythrocyte Life Span
- (2014) Mehmet Yabas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis
- (2014) Jun Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane
- (2014) Hiroyuki Takatsu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ANO10 mutations cause ataxia and coenzyme Q10 deficiency
- (2014) Andrea Balreira et al. JOURNAL OF NEUROLOGY
- Role of Phosphatidylserine Receptors in Enveloped Virus Infection
- (2014) K. Morizono et al. JOURNAL OF VIROLOGY
- Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages
- (2014) C. Nishi et al. MOLECULAR AND CELLULAR BIOLOGY
- X-ray structure of a calcium-activated TMEM16 lipid scramblase
- (2014) Janine D. Brunner et al. NATURE
- Common variants associated with general and MMR vaccine–related febrile seizures
- (2014) Bjarke Feenstra et al. NATURE GENETICS
- Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2
- (2014) A. L. Vestergaard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TIM-family proteins inhibit HIV-1 release
- (2014) M. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins
- (2014) M. Pinot et al. SCIENCE
- Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
- (2014) K. Segawa et al. SCIENCE
- Phospholipid Synthesis and Transport in Mammalian Cells
- (2014) Jean E. Vance TRAFFIC
- Autosomal Recessive Cerebellar Ataxia Type 3 Due toANO10Mutations
- (2014) Mathilde Renaud et al. JAMA Neurology
- Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members
- (2013) Jun Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tissue-resident macrophages
- (2013) Luke C Davies et al. NATURE IMMUNOLOGY
- Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
- (2013) Christiane Mühle et al. PLoS One
- Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases
- (2013) R. D. Baldridge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
- (2013) J. Suzuki et al. SCIENCE
- Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis
- (2012) Gavin Charlesworth et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport
- (2012) Jonathan A. Coleman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation
- (2012) Huanghe Yang et al. CELL
- A novel missense mutation in ANO5/TMEM16E is causative for gnathodiaphyseal dyplasia in a large Italian pedigree
- (2012) Caterina Marconi et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity
- (2012) M. Miyanishi et al. INTERNATIONAL IMMUNOLOGY
- Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues
- (2012) Harald WA Ehlen et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Mutations in a P-Type ATPase Gene Cause Axonal Degeneration
- (2012) Xianjun Zhu et al. PLoS Genetics
- ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins
- (2011) Charity Duran et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- P-Type ATPases
- (2011) Michael G. Palmgren et al. Annual Review of Biophysics
- Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes
- (2011) Jaemin Jeong et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome
- (2011) E. Castoldi et al. BLOOD
- Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning
- (2011) Kelly Levano et al. JOURNAL OF NEUROCHEMISTRY
- Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity
- (2011) Gregory D. Fairn et al. NATURE CELL BIOLOGY
- ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
- (2011) Mehmet Yabas et al. NATURE IMMUNOLOGY
- The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
- (2011) Owen M Siggs et al. NATURE IMMUNOLOGY
- Anoctamin 6 is an essential component of the outwardly rectifying chloride channel
- (2011) J. R. Martins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
- (2011) O. M. Siggs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria
- (2011) Soumita Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Constitutive exposure of phosphatidylserine on viable cells
- (2011) K. Segawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Next-Generation Sequencing of a 12.5 Mb Homozygous Region Reveals ANO10 Mutations in Patients with Autosomal-Recessive Cerebellar Ataxia
- (2010) Sascha Vermeer et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The Distribution and Function of Phosphatidylserine in Cellular Membranes
- (2010) Peter A. Leventis et al. Annual Review of Biophysics
- Autoimmunity and the Clearance of Dead Cells
- (2010) Shigekazu Nagata et al. CELL
- Phospholipid scramblase: An update
- (2010) Edouard M. Bevers et al. FEBS LETTERS
- Expression and Function of Epithelial Anoctamins
- (2010) Rainer Schreiber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calcium-dependent phospholipid scrambling by TMEM16F
- (2010) Jun Suzuki et al. NATURE
- The role of defective clearance of apoptotic cells in systemic autoimmunity
- (2010) Luis E. Muñoz et al. Nature Reviews Rheumatology
- Mechanism and significance of P4 ATPase-catalyzed lipid transport: Lessons from a Na+/K+-pump
- (2009) Catheleyne F. Puts et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
- (2009) S. M. Schoenwaelder et al. BLOOD
- Apaf-1-independent programmed cell death in mouse development
- (2009) A Nagasaka et al. CELL DEATH AND DIFFERENTIATION
- TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A
- (2009) Joana Almaça et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes
- (2009) Jonathan A. Coleman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion
- (2009) L. Helming et al. JOURNAL OF CELL SCIENCE
- ATP8B1 is essential for maintaining normal hearing
- (2009) J. M. Stapelbroek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of membrane fusion: disparate players and common principles
- (2008) Sascha Martens et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
- (2008) T. Yeung et al. SCIENCE
- Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells
- (2008) J. Mercer et al. SCIENCE
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