Journal
NATURE MEDICINE
Volume 28, Issue 12, Pages 2486-2496Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-022-02104-7
Keywords
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Funding
- Wellcome [206194, 108413/A/15/D]
- Wellcome Trust [108413/A/15/D] Funding Source: Wellcome Trust
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Single-cell atlases have the potential to bridge the gap between genes, diseases, and therapies. By understanding disease mechanisms at the cellular and tissue levels, they can aid in disease diagnostics, drug target identification, and the development of new therapies.
Single-cell atlases promise to provide a 'missing link' between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act, we will understand the mechanisms of disease at the cellular and tissue levels and can use this understanding to develop powerful disease diagnostics; identify promising new drug targets; predict their efficacy, toxicity and resistance mechanisms; and empower new kinds of therapies, from cancer therapies to regenerative medicine. Here, we lay out a vision for the potential of cell atlases to impact the future of medicine, and describe how advances over the past decade have begun to realize this potential in common complex diseases, infectious diseases (including COVID-19), rare diseases and cancer.
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