Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses

(2015) Ying-Han Chen et al.   CELL

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

(2015) Toshihiro Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding

(2015) Jiangfeng Du et al.   THROMBOSIS AND HAEMOSTASIS

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

(2014) S. Toda et al.   BLOOD

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition

(2014) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

Role of Phosphatidylserine in Phospholipid Flippase-Mediated Vesicle Transport in Saccharomyces cerevisiae

(2014) Miyoko Takeda et al.   EUKARYOTIC CELL

The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets

(2014) Mona HC Biermann et al.   Expert Review of Clinical Immunology

A Hyaluronan Receptor for Endocytosis (HARE) Link DomainN-Glycan Is Required for Extracellular Signal-regulated Kinase (ERK) and Nuclear Factor-κB (NF-κB) Signaling in Response to the Uptake of Hyaluronan but Not Heparin, Dermatan Sulfate, or Acetylated Low Density Lipoprotein (LDL)

(2014) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Auto-Oxidation and Oligomerization of Protein S on the Apoptotic Cell Surface Is Required for Mer Tyrosine Kinase-Mediated Phagocytosis of Apoptotic Cells

(2014) H. Uehara et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

(2014) H. Paidassi et al.   JOURNAL OF IMMUNOLOGY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4

(2014) G. T. Tietjen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Fibrinogen and red blood cells in venous thrombosis

(2014) Maria M. Aleman et al.   THROMBOSIS RESEARCH

Insights into platelet-based control of coagulation

(2014) Susanne M. de Witt et al.   THROMBOSIS RESEARCH

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

(2014) Linjie Tian et al.   Nature Communications

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dynamic adhesion of eryptotic erythrocytes to immobilized platelets via platelet phosphatidylserine receptors

(2013) Britta Walker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans

(2013) Ying Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Activation of blood coagulation in cancer: implications for tumour progression

(2013) Luize G. Lima et al.   BIOSCIENCE REPORTS

Rational design of small molecules targeting the C2 domain of coagulation factor VIII

(2013) G. A. F. Nicolaes et al.   BLOOD

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation

(2013) R. van Kruchten et al.   BLOOD

Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System

(2013) Tim J. Schuijt et al.   CIRCULATION

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper

(2013) Tran Thanh Tung et al.   JOURNAL OF BIOCHEMISTRY

Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage

(2013) Harlan N. Bradford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular annexins and dynamin are important for sequential steps in myoblast fusion

(2013) Evgenia Leikina et al.   JOURNAL OF CELL BIOLOGY

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Caspase Activity Is Required for Engulfment of Apoptotic Cells

(2013) Boris Shklyar et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

P4-ATPases: lipid flippases in cell membranes

(2013) Rosa L. Lopez-Marques et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

(2013) J. Tien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Transient Receptor Potential Channels Function as a Coincidence Signal Detector Mediating Phosphatidylserine Exposure

(2013) M. T. Harper et al.   Science Signaling

The role of the red cell membrane in thrombin generation

(2013) Matthew F. Whelihan et al.   THROMBOSIS RESEARCH

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

(2013) Leon J. Schurgers et al.   TRENDS IN MOLECULAR MEDICINE

Flavivirus Entry Receptors: An Update

(2013) Manuel Perera-Lecoin et al.   Viruses-Basel

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity

(2013) M T Harper et al.   Cell Death & Disease

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization

(2013) Yu-Zen Chen et al.   Nature Communications

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

(2013) Stephanie Jemielity et al.   PLoS Pathogens

Mechanisms tagging senescent red blood cells for clearance in healthy humans

(2013) Hans U. Lutz et al.   Frontiers in Physiology

Changes in the properties of normal human red blood cells during in vivo aging

(2012) Robert S. Franco et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mitochondrial Calcium and Reactive Oxygen Species Regulate Agonist-Initiated Platelet Phosphatidylserine Exposure

(2012) Hyo-Jung Choo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation

(2012) M. F. Whelihan et al.   BLOOD

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

(2012) V. R. Simhadri et al.   BLOOD

Role of microparticles in sepsis

(2012) V.L. Reid et al.   BRITISH JOURNAL OF ANAESTHESIA

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

C. elegans Secreted Lipid-Binding Protein NRF-5 Mediates PS Appearance on Phagocytes for Cell Corpse Engulfment

(2012) Yan Zhang et al.   CURRENT BIOLOGY

CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells

(2012) James Mapes et al.   CURRENT BIOLOGY

Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment

(2012) Y. Kang et al.   GENES & DEVELOPMENT

Prothrombin Activation by Platelet-associated Prothrombinase Proceeds through the Prethrombin-2 Pathway via a Concerted Mechanism

(2012) Laura M. Haynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Platelet-based coagulation: different populations, different functions

(2012) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic Dissection of TAM Receptor-Ligand Interaction in Retinal Pigment Epithelial Cell Phagocytosis

(2012) Tal Burstyn-Cohen et al.   NEURON

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina

(2012) L. Ruggiero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Plant P-Type ATPases

(2012) Christian N. S. Pedersen et al.   Frontiers in Plant Science

ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

(2011) Charity Duran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation

(2011) Monowar Aziz et al.   APOPTOSIS

Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes

(2011) Jaemin Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane-binding properties of the Factor VIII C2 domain

(2011) Valerie A. Novakovic et al.   BIOCHEMICAL JOURNAL

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Opsin Is a Phospholipid Flippase

(2011) Indu Menon et al.   CURRENT BIOLOGY

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

Molecular Determinants of Phospholipid Synergy in Blood Clotting

(2011) Narjes Tavoosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine Membrane Translocation in Human Spermatozoa: Topography in Membrane Domains and Relation to Cell Vitality

(2011) Malgorzata Kotwicka et al.   JOURNAL OF MEMBRANE BIOLOGY

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

(2011) Helena Païdassi et al.   JOURNAL OF MOLECULAR BIOLOGY

Matrix Gla Protein Inhibits Ectopic Calcification by a Direct Interaction with Hydroxyapatite Crystals

(2011) Jason O’Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β2-Glycoprotein I: evolution, structure and function

(2011) P. G. DE GROOT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Two-Step Engulfment of Apoptotic Cells

(2011) S. Toda et al.   MOLECULAR AND CELLULAR BIOLOGY

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Neuroacanthocytosis Syndromes

(2011) Hans H Jung et al.   Orphanet Journal of Rare Diseases

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased motility of human spermatozoa presenting phosphatidylserine membrane translocation-cells selection with the swim-up technique

(2011) Malgorzata Kotwicka et al.   Human Cell

HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin

(2010) Arnaud Friggeri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular Mechanisms Underlying the Formation of Circulating Microparticles

(2010) Olivier Morel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function

(2010) J. Lu et al.   BLOOD

Mystery of the transformation from amorphous calcium phosphate to hydroxyapatite

(2010) Haihua Pan et al.   CHEMICAL COMMUNICATIONS

Defect-Mediated Trafficking across Cell Membranes: Insights fromin SilicoModeling

(2010) Andrey A. Gurtovenko et al.   CHEMICAL REVIEWS

The molecular identity of the mitochondrial Ca2+ sequestration system

(2010) Anatoly A. Starkov   FEBS Journal

Expression and Function of Epithelial Anoctamins

(2010) Rainer Schreiber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells

(2010) Rosemarie H. DeKruyff et al.   JOURNAL OF IMMUNOLOGY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

(2010) Xiaochen Wang et al.   NATURE CELL BIOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine exposure and microparticles release

(2010) Huibo Li et al.   THROMBOSIS AND HAEMOSTASIS

Oligomeric Dop1p is Part of the Endosomal Neo1p-Ysl2p-Arl1p Membrane Remodeling Complex

(2010) Sónia Barbosa et al.   TRAFFIC

TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

(2010) Chang-Hee Suh et al.   ARTHRITIS RESEARCH & THERAPY

Rapid Procoagulant Phosphatidylserine Exposure Relies on High Cytosolic Calcium Rather Than on Mitochondrial Depolarization

(2009) Amal Arachiche et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The TMEM16 Protein Family: A New Class of Chloride Channels?

(2009) Luis J.V. Galietta   BIOPHYSICAL JOURNAL

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

The Phosphatidylserine Receptor TIM-4 Does Not Mediate Direct Signaling

(2009) Daeho Park et al.   CURRENT BIOLOGY

Asymmetrical stress generated by the erythrocyte lipid flippase triggers multiple bud formation on the surface of spherical giant liposomes

(2009) Pierre Ezanno et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+ and ATP Released from Injured Cells Induce P2X7-Dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells

(2009) F. Scheuplein et al.   JOURNAL OF IMMUNOLOGY

Phospholipid flip-flop modulated by transmembrane peptides WALP and melittin

(2009) Timothy C. Anglin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Role of Phosphatidyl-Serine in Bone Repair and Its Technological Exploitation

(2009) Antonio Merolli et al.   MOLECULES

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Lactadherin and clearance of platelet-derived microvesicles

(2008) S. K. Dasgupta et al.   BLOOD

Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level

(2008) S. Das et al.   CANCER RESEARCH

Six-Microns-Under Acts Upstream of Draper in the Glial Phagocytosis of Apoptotic Neurons

(2008) Estee Kurant et al.   CELL

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions

(2008) J. L. N. Wolfs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thymosin β4 is involved in stabilin-2-mediated apoptotic cell engulfment

(2008) Sung-Jin Lee et al.   FEBS LETTERS

Erythrocyte programmed cell death

(2008) Michael Föller et al.   IUBMB LIFE

Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment

(2008) Seung-Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of apoptosis and lipid peroxidation on T-lymphoblastoid phospholipid-dependent procoagulant activity

(2008) W. PICKERING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Epidermal Growth Factor-Like Domain Repeat of Stabilin-2 Recognizes Phosphatidylserine during Cell Corpse Clearance

(2008) S.-Y. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE