Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

(2018) Giulia Morra et al.   STRUCTURE

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

Characterization of the scrambling domain of the TMEM16 family

(2017) Sayuri Gyobu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

(2017) Tao Jiang et al.   eLife

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

(2017) Angela J Churchill et al.   eLife

An engineered opsin monomer scrambles phospholipids

(2017) Kalpana Pandey et al.   Scientific Reports

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

(2016) Byoung-Cheol Lee et al.   BIOPHYSICAL JOURNAL

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Defective membrane fusion and repair inAnoctamin5-deficient muscular dystrophy

(2016) Danielle A. Griffin et al.   HUMAN MOLECULAR GENETICS

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping

(2016) Thomas Günther Pomorski et al.   PROGRESS IN LIPID RESEARCH

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants

(2016) Birgit Ploier et al.   Nature Communications

A Fluorescence-based Assay of Phospholipid Scramblase Activity

(2016) Birgit Ploier et al.   Jove-Journal of Visualized Experiments

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

(2015) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

(2015) Sayuri Gyobu et al.   MOLECULAR AND CELLULAR BIOLOGY

Phospholipid scrambling by rhodopsin

(2015) Oliver P. Ernst et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F

(2014) Takayuki Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

(2014) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Constitutive phospholipid scramblase activity of a G protein-coupled receptor

(2014) Michael A. Goren et al.   Nature Communications

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Opsin Is a Phospholipid Flippase

(2011) Indu Menon et al.   CURRENT BIOLOGY

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) David Drew et al.   Nature Protocols

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE