The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction

ANO5 ensures trafficking of annexins in wounded myofibers

(2021) Steven J. Foltz et al.   JOURNAL OF CELL BIOLOGY

Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins

(2021) Dung Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

(2021) Andy K. M. Lam et al.   Nature Communications

Gating the pore of the calcium-activated chloride channel TMEM16A

(2021) Andy K. M. Lam et al.   Nature Communications

Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

(2021) Zhiguang Jia et al.   Communications Biology

Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

(2020) Valentina Arkhipova et al.   Nature Communications

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

(2020) Ning Wu et al.   Cell Reports

Elevator-type mechanisms of membrane transport

(2020) Alisa A. Garaeva et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation

(2020) Dung M. Nguyen et al.   PLoS One

Membrane mediated toppling mechanism of the folate energy coupling factor transporter

(2020) Ignacio Faustino et al.   Nature Communications

Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A)

(2020) Guadalupe Segura-Covarrubias et al.   Scientific Reports

TMEM16K is an interorganelle regulator of endosomal sorting

(2020) Maja Petkovic et al.   Nature Communications

Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance

(2020) Zengqin Deng et al.   Nature Communications

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation

(2020) Son C. Le et al.   Cell Reports

Lifting the veils on TMEM16E function

(2019) Anna Boccaccio et al.   Channels

Chemically induced vesiculation as a platform for studying TMEM16F activity

(2019) Tina W. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

(2019) Anamika Dayal et al.   Nature Communications

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

(2019) Maria E Falzone et al.   eLife

Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel

(2019) Nadine Reichhart et al.   Scientific Reports

Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment

(2019) Archana Jha et al.   EMBO JOURNAL

An inner activation gate controls TMEM16F phospholipid scrambling

(2019) Trieu Le et al.   Nature Communications

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

(2019) Carolina Alvadia et al.   eLife

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

(2019) Valeria Kalienkova et al.   eLife

Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A

(2019) Maiwase Tembo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating

(2019) Koustav Maity et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

(2019) Shengjie Feng et al.   Cell Reports

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

(2019) Wenlei Ye et al.   eLife

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)

(2019) Kuai Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

(2019) Ke-Xin Li et al.   eLife

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins

(2019) George Khelashvili et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis

(2019) Roberto Quesada et al.   Journal of Cystic Fibrosis

Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes

(2019) Marc Siggel et al.   Journal of Physical Chemistry Letters

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

(2019) Son C. Le et al.   Nature Communications

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

(2019) Simon R. Bushell et al.   Nature Communications

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

(2019) George Khelashvili et al.   Nature Communications

Large-scale state-dependent membrane remodeling by a transporter protein

(2019) Wenchang Zhou et al.   eLife

Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)

(2018) José J. De Jesús-Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal

(2018) Hyungsup Kim et al.   CELL CALCIUM

Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl− Channel Regulation in Cerebrovascular Cells

(2018) Cai-Xia Lin et al.   CIRCULATION JOURNAL

Structural mapping of fluorescently-tagged, functional nhTMEM16 scramblase in a lipid bilayer

(2018) Kiran K. Andra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Known structures and unknown mechanisms of TMEM16 scramblases and channels

(2018) Maria E. Falzone et al.   JOURNAL OF GENERAL PHYSIOLOGY

The TMEM16A channel mediates the fast polyspermy block inXenopus laevis

(2018) Katherine L. Wozniak et al.   JOURNAL OF GENERAL PHYSIOLOGY

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel

(2018) Christian J. Peters et al.   NEURON

An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase

(2018) Thomas Pelz et al.   PLoS One

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases

(2018) Arturo Medrano-Soto et al.   PLoS One

Single-molecule analysis of phospholipid scrambling by TMEM16F

(2018) Rikiya Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F

(2018) Wenlei Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases

(2018) Mattia Malvezzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

(2018) Giulia Morra et al.   STRUCTURE

Inhibition of Ca2+ -activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling

(2018) Zongtao Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion

(2018) Jarred M. Whitlock et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the mechanosensitive OSCA channels

(2018) Mingfeng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

(2018) Bifeng Pan et al.   NEURON

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

(2018) Byoung-Cheol Lee et al.   Nature Communications

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

(2018) Angela Ballesteros et al.   eLife

Recent advances in TMEM16A: Structure, function, and disease

(2018) Qiushuang Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2

(2018) Xin Liu et al.   Nature Communications

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

(2018) Sebastian Jojoa-Cruz et al.   eLife

Piezo’s membrane footprint and its contribution to mechanosensitivity

(2018) Christoph A Haselwandter et al.   eLife

Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

(2018) Andy KM Lam et al.   eLife

TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl−current and regulate melatonin secretion in rat pineal glands

(2017) Hisao Yamamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

(2017) Hui Wang et al.   Molecular Cancer

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning

(2017) Yang Zhang et al.   NEURON

Characterization of the scrambling domain of the TMEM16 family

(2017) Sayuri Gyobu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poring over furrows

(2017) Skylar ID Fisher et al.   eLife

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

(2017) Tao Jiang et al.   eLife

Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels

(2017) Simone Pifferi   PLoS One

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

(2016) Byoung-Cheol Lee et al.   BIOPHYSICAL JOURNAL

Defective membrane fusion and repair inAnoctamin5-deficient muscular dystrophy

(2016) Danielle A. Griffin et al.   HUMAN MOLECULAR GENETICS

TMEM16 chloride channels are two-faced

(2016) H. Criss Hartzell et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Ca2+-activated Cl−channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons

(2016) Gianluca Pietra et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of distinct pores in dimeric TMEM16A channels

(2016) Grace Jeng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

(2016) Novandy K. Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models

(2016) Juan A. Contreras-Vite et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cellular functions of TMEM16/anoctamin

(2016) Uhtaek Oh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells

(2016) Young-Sun Lee et al.   Scientific Reports

TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States

(2016) Laura Batti et al.   Cell Reports

Protons inhibit anoctamin 1 by competing with calcium

(2015) Hyeyeon Chun et al.   CELL CALCIUM

Calmodulin regulation of TMEM16A and 16B Ca2+-activated chloride channels

(2015) Tingting Yang et al.   Channels

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

(2015) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B

(2015) Silvia Cruz-Rangel et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

(2015) Sayuri Gyobu et al.   MOLECULAR AND CELLULAR BIOLOGY

Unknown

(2015) Christian Hammer et al.   MOLECULAR MEDICINE

A fluid secretion pathway unmasked by acinar-specificTmem16Agene ablation in the adult mouse salivary gland

(2015) Marcelo A. Catalán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

(2015) Toshihiro Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling

(2015) Fang Liu et al.   Oncotarget

Identification and characterization of ANO9 in stage II and III colorectal carcinoma

(2015) Chunxiang Li et al.   Oncotarget

TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation

(2015) Ronak Dixit et al.   Scientific Reports

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

(2015) Linghan Jia et al.   PLoS One

Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery

(2014) H A T Pritchard et al.   BRITISH JOURNAL OF PHARMACOLOGY

The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis

(2014) Elvira Sondo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F

(2014) Takayuki Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel

(2014) Giulia Betto et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

(2014) Kuai Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Does calmodulin regulate the bicarbonate permeability of ANO1/TMEM16A or not?

(2014) Jinsei Jung et al.   JOURNAL OF GENERAL PHYSIOLOGY

Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity

(2014) Byeongjun Lee et al.   Molecular Pain

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

(2014) Yu-Li Ni et al.   PLoS One

Acidic Amino Acids in the First Intracellular Loop Contribute to Voltage- and Calcium- Dependent Gating of Anoctamin1/TMEM16A

(2014) Qinghuan Xiao et al.   PLoS One

Inhibition of TMEM16A Expression Suppresses Growth and Invasion in Human Colorectal Cancer Cells

(2014) Yujie Sui et al.   PLoS One

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

(2014) Jason Tien et al.   eLife

Autosomal Recessive Cerebellar Ataxia Type 3 Due toANO10Mutations

(2014) Mathilde Renaud et al.   JAMA Neurology

Reduced expression of NGEP is associated with high-grade prostate cancers: a tissue microarray analysis

(2013) Monireh Mohsenzadegan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels

(2013) Kerstin Vocke et al.   JOURNAL OF GENERAL PHYSIOLOGY

TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing

(2013) Fen Huang et al.   NATURE NEUROSCIENCE

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

(2013) J. Tien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Subdued, a TMEM16 family Ca2+-activated Cl− channel in Drosophila melanogaster with an unexpected role in host defense

(2013) Xiu Ming Wong et al.   eLife

Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis

(2012) Gavin Charlesworth et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanosensitive Cl− secretion in biliary epithelium mediated through TMEM16A

(2012) Amal K. Dutta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries

(2012) Simon Bulley et al.   CIRCULATION RESEARCH

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

A novel missense mutation in ANO5/TMEM16E is causative for gnathodiaphyseal dyplasia in a large Italian pedigree

(2012) Caterina Marconi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The voltage dependence of the TMEM16B/anoctamin2 calcium-activated chloride channel is modified by mutations in the first putative intracellular loop

(2012) Valentina Cenedese et al.   JOURNAL OF GENERAL PHYSIOLOGY

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

(2012) Wendy C. Huang et al.   NEURON

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels?

(2011) Charity Duran et al.   ACTA PHARMACOLOGICA SINICA

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing

(2011) Kate E O'Driscoll et al.   BMC MOLECULAR BIOLOGY

ANO10 c.1150_1151del is a founder mutation causing autosomal recessive cerebellar ataxia in Roma/Gypsies

(2011) Teodora Chamova et al.   JOURNAL OF NEUROLOGY

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Next-Generation Sequencing of a 12.5 Mb Homozygous Region Reveals ANO10 Mutations in Patients with Autosomal-Recessive Cerebellar Ataxia

(2010) Sascha Vermeer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recessive Mutations in the Putative Calcium-Activated Chloride Channel Anoctamin 5 Cause Proximal LGMD2L and Distal MMD3 Muscular Dystrophies

(2010) Véronique Bolduc et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Expression profile and protein translation of TMEM16A in murine smooth muscle

(2010) Alison J. Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

A founder mutation in Anoctamin 5 is a major cause of limb girdle muscular dystrophy

(2010) D. Hicks et al.   BRAIN

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

(2010) Yuemin Tian et al.   FASEB JOURNAL

Expression and Function of Epithelial Anoctamins

(2010) Rainer Schreiber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

A new distal myopathy with mutation in anoctamin 5

(2010) Ibrahim Mahjneh et al.   NEUROMUSCULAR DISORDERS

Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract

(2009) Pedro J. Gomez-Pinilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Novel Monoclonal Antibody Against DOG1 is a Sensitive and Specific Marker for Gastrointestinal Stromal Tumors

(2009) Inigo Espinosa et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Chloride Channels: Often Enigmatic, Rarely Predictable

(2009) Charity Duran et al.   Annual Review of Physiology

Phosphorylation alters the pharmacology of Ca2+-activated Cl- channels in rabbit pulmonary arterial smooth muscle cells

(2009) M Wiwchar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anoctamin and transmembrane channel-like proteins are evolutionarily related

(2009) Hahn   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+-activated Cl−conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

(2009) Mei Hong Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

(2009) Sung Jin Hwang et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies on expression and function of the TMEM16A calcium-activated chloride channel

(2009) Fen Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level

(2008) S. Das et al.   CANCER RESEARCH

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Expression of TMEM16 paralogs during murine embryogenesis

(2008) Jason R. Rock et al.   DEVELOPMENTAL DYNAMICS

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY