X-ray structure of a calcium-activated TMEM16 lipid scramblase

Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F

(2014) Takayuki Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

(2014) Kuai Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

(2014) Yu-Li Ni et al.   PLoS One

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

(2014) A. L. Vestergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

(2014) L.-T. Sham et al.   SCIENCE

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

(2014) Jason Tien et al.   eLife

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of a ClC transporter by solid-supported membrane electrophysiology

(2013) Juan Garcia-Celma et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels

(2013) Kerstin Vocke et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

(2013) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

(2013) J. Tien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases

(2012) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

Opsin Is a Phospholipid Flippase

(2011) Indu Menon et al.   CURRENT BIOLOGY

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

(2011) Tamimount Mohammadi et al.   EMBO JOURNAL

Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction

(2011) Simone Pifferi et al.   EXPERIMENTAL PHYSIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Ca2+-activated Cl− currents are dispensable for olfaction

(2011) Gwendolyn M Billig et al.   NATURE NEUROSCIENCE

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

(2011) Iwan Zimmermann et al.   PLOS BIOLOGY

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

(2010) Yuemin Tian et al.   FASEB JOURNAL

Characterization of the Oligomeric Structure of the Ca2+-activated Cl−Channel Ano1/TMEM16A

(2010) John T. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels

(2010) Ghada Fallah et al.   MOLECULAR & CELLULAR PROTEOMICS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Stereoselective transbilayer translocation of mannosyl phosphoryl dolichol by an endoplasmic reticulum flippase

(2010) S. Sanyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flipping Lipids: Why an’ What’s the Reason for?

(2009) Sumana Sanyal et al.   ACS Chemical Biology

A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles

(2009) Stephan Schenck et al.   NATURE NEUROSCIENCE

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) David Drew et al.   Nature Protocols

Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE