Exposure of phosphatidylserine on the cell surface

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase

(2015) S. Lee et al.   EMBO JOURNAL

Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium

(2015) Katsumori Segawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics

(2015) Tomoki Naito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inner workings and biological impact of phospholipid flippases

(2015) R. Panatala et al.   JOURNAL OF CELL SCIENCE

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

(2015) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

ATMEM16Fpoint mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling

(2015) M. B. Brooks et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Viral apoptotic mimicry

(2015) Ali Amara et al.   NATURE REVIEWS MICROBIOLOGY

Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations

(2015) Marco Savarese et al.   NEUROMUSCULAR DISORDERS

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

(2015) Toshihiro Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

(2015) Zao Li et al.   PLoS Genetics

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer

(2015) Pavani Chalasani et al.   Cancer Medicine

Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium

(2015) Jason H. Stafford et al.   NEOPLASIA

Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F

(2014) Takayuki Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Deficient in the Putative Phospholipid Flippase ATP11C Exhibit Altered Erythrocyte Shape, Anemia, and Reduced Erythrocyte Life Span

(2014) Mehmet Yabas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

(2014) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane

(2014) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ANO10 mutations cause ataxia and coenzyme Q10 deficiency

(2014) Andrea Balreira et al.   JOURNAL OF NEUROLOGY

Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer

(2014) Raghunadharao Digumarti et al.   LUNG CANCER

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans

(2013) Ying Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

(2013) Qiang Wang et al.   INTERNATIONAL IMMUNOLOGY

Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper

(2013) Tran Thanh Tung et al.   JOURNAL OF BIOCHEMISTRY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

(2013) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation

(2013) Y. Yin et al.   Cancer Immunology Research

Mechanisms tagging senescent red blood cells for clearance in healthy humans

(2013) Hans U. Lutz et al.   Frontiers in Physiology

Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis

(2012) Gavin Charlesworth et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity

(2012) M. Miyanishi et al.   INTERNATIONAL IMMUNOLOGY

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

(2011) T. Bergsbaken et al.   JOURNAL OF IMMUNOLOGY

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

(2011) Owen M Siggs et al.   NATURE IMMUNOLOGY

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C

(2011) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Next-Generation Sequencing of a 12.5 Mb Homozygous Region Reveals ANO10 Mutations in Patients with Autosomal-Recessive Cerebellar Ataxia

(2010) Sascha Vermeer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Functions of phospholipid flippases

(2010) K. Tanaka et al.   JOURNAL OF BIOCHEMISTRY

Expression and Function of Epithelial Anoctamins

(2010) Rainer Schreiber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

(2010) Baohui Chen et al.   PLoS Genetics

P4 ATPases - Lipid flippases and their role in disease

(2009) Dineke E. Folmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The TMEM16 Protein Family: A New Class of Chloride Channels?

(2009) Luis J.V. Galietta   BIOPHYSICAL JOURNAL

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

TMEM16 proteins: the long awaited calcium-activated chloride channels?

(2009) C.A. Flores et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flip-Flop of Phospholipids in Vesicles: Kinetic Analysis with Time-Resolved Small-Angle Neutron Scattering

(2009) Minoru Nakano et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

The Putative Aminophospholipid Translocases,DNF1andDNF2, Are Not Required for 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine Flip across the Plasma Membrane ofSaccharomyces cerevisiae

(2008) Haley C. Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase

(2008) Eun-Yeung Gong et al.   REPRODUCTION

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE