3D organ-on-a-chip: The convergence of microphysiological systems and organoids

Human organs-on-chips for disease modelling, drug development and personalized medicine

(2022) Donald E. Ingber   NATURE REVIEWS GENETICS

Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids

(2022) Jin Won Kim et al.   Advanced Science

Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment

(2022) Muhammad R. Haque et al.   Microsystems & Nanoengineering

Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids

(2022) Paola Spitalieri et al.   Cells

Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment

(2022) Hyemin Kim et al.   BIOMATERIALS

Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration

(2021) Molong Qu et al.   CELL RESEARCH

Organoid Cultures Derived From Patients With Papillary Thyroid Cancer

(2021) Dong Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An organoid-based organ-repurposing approach to treat short bowel syndrome

(2021) Shinya Sugimoto et al.   NATURE

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

(2021) Kristin M. Bircsak et al.   TOXICOLOGY

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

(2021) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease

(2021) Bradley R. Groveman et al.   Scientific Reports

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

(2021) Krijn K. Dijkstra et al.   Frontiers in Endocrinology

Vascular deficiencies in renal organoids and ex vivo kidney organogenesis

(2021) Anne R. Ryan et al.   DEVELOPMENTAL BIOLOGY

3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review

(2021) Violeta Carvalho et al.   SENSORS

Engineering spatial-organized cardiac organoids for developmental toxicity testing

(2021) Plansky Hoang et al.   Stem Cell Reports

Human pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing

(2021) Jung-Hyun Kim et al.   Cell Death Discovery

Advancing lung organoids for COVID-19 research

(2021) Jelte van der Vaart et al.   Disease Models & Mechanisms

SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis

(2021) Ping Tan et al.   ONCOGENE

Development of patient‑derived tumor organoids and a drug testing model for renal cell carcinoma

(2021) Akira Kazama et al.   ONCOLOGY REPORTS

Kidney organoids generated from erythroid progenitors cells of patients with autosomal dominant polycystic kidney disease

(2021) Roberta Facioli et al.   PLoS One

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

(2021) Ann-Na Cho et al.   Nature Communications

Facile Route for 3D Printing of Transparent PETg-Based Hybrid Biomicrofluidic Devices Promoting Cell Adhesion

(2021) Viraj Mehta et al.   ACS Biomaterials-Science & Engineering

Successful Patient-Derived Organoid Culture of Gynecologic Cancers for Disease Modeling and Drug Sensitivity Testing

(2021) Jianling Bi et al.   Cancers

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

(2021) Nicholas Choo et al.   SLAS Discovery

Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids

(2021) Ana C. Silva et al.   Cell Stem Cell

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer

(2021) Joseph E. Grossman et al.   CLINICAL CANCER RESEARCH

Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies

(2021) Manon C. Bouwmeester et al.   MACROMOLECULAR BIOSCIENCE

Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson’s Disease

(2020) Chlebanowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput

(2020) Erin Maloney et al.   Micromachines

Pancreatic cancer-derived organoids – a disease modeling tool to predict drug response

(2020) Pierre-Olivier Frappart et al.   United European Gastroenterology Journal

Generation of intestinal organoids derived from human pluripotent stem cells for drug testing

(2020) Shinpei Yoshida et al.   Scientific Reports

3D Printing of Inertial Microfluidic Devices

(2020) Sajad Razavi Bazaz et al.   Scientific Reports

Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models

(2020) Nina Maenhoudt et al.   Stem Cell Reports

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases

(2020) Mi Jian et al.   Journal of Translational Medicine

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease

(2020) Sarah Louise Nickels et al.   Stem Cell Research

Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing

(2020) Yoshiko Nanki et al.   Scientific Reports

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

(2020) Chris Jenske de Witte et al.   Cell Reports

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Organoids, Assembloids, and Novel Biotechnology: Steps Forward in Developmental and Disease-Related Neuroscience

(2020) Alexios A. Panoutsopoulos   NEUROSCIENTIST

Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System

(2020) Yaqing Wang et al.   ACS Biomaterials-Science & Engineering

A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

(2020) James A. Saltsman et al.   Cancers

Creating rat hepatocyte organoid as an in vitro model for drug testing

(2020) Yu-Ting He et al.   World Journal of Stem Cells

PDX-derived organoids model in vivo drug response and secrete biomarkers

(2020) Ling Huang et al.   JCI Insight

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

(2020) Kynan T. Lawlor et al.   NATURE MATERIALS

Rethinking organoid technology through bioengineering

(2020) Elena Garreta et al.   NATURE MATERIALS

Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment

(2020) Elena Campaner et al.   Cancers

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

(2019) Jungwook Paek et al.   ACS Nano

3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels

(2019) Peter A. Mollica et al.   Acta Biomaterialia

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

(2019) Rie Ouchi et al.   Cell Metabolism

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids

(2019) John A. Reid et al.   Scientific Reports

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

(2019) Kevin Achberger et al.   eLife

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

(2019) Shuyong Wang et al.   CELL RESEARCH

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

Organoid cultures as preclinical models of non-small cell lung cancer

(2019) Ruoshi Shi et al.   CLINICAL CANCER RESEARCH

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Bioprinting a 3D vascular construct for engineering a vessel-on-a-chip

(2019) Mieradilijiang Abudupataer et al.   BIOMEDICAL MICRODEVICES

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

(2019) Else Driehuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Human gastric cancer modelling using organoids

(2018) Therese Seidlitz et al.   GUT

Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications

(2018) Tobias Grix et al.   Genes

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis

(2018) Chris P. Miller et al.   NEOPLASIA

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices

(2017) Julie Lachaux et al.   LAB ON A CHIP

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Organoid Culture of Isolated Cells from Patient-derived Tissues with Colorectal Cancer

(2016) Ai-Wen Wu et al.   CHINESE MEDICAL JOURNAL

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Current Challenges and Controversies in Drug-Induced Liver Injury

(2013) Alberto Corsini et al.   DRUG SAFETY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE