Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids

Human heart-forming organoids recapitulate early heart and foregut development

(2021) Lika Drakhlis et al.   NATURE BIOTECHNOLOGY

Self-Organizing 3D Human Trunk Neuromuscular Organoids

(2020) Jorge-Miguel Faustino Martins et al.   Cell Stem Cell

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

(2020) Viola Volpato et al.   Disease Models & Mechanisms

Single cell determination of cardiac microtissue structure and function using light sheet microscopy

(2020) Diwakar Turaga et al.   TISSUE ENGINEERING PART C-METHODS

In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

(2020) Jiyoung Lee et al.   Nature Communications

Capturing Cardiogenesis in Gastruloids

(2020) Giuliana Rossi et al.   Cell Stem Cell

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

(2019) Yueli Cui et al.   Cell Reports

Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function

(2019) Tracy A. Hookway et al.   TISSUE ENGINEERING PART A

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

(2019) Hiroyuki Koike et al.   NATURE

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

(2019) Michaela Asp et al.   CELL

The heart tube forms and elongates through dynamic cell rearrangement coordinated with foregut extension

(2018) Hinako Kidokoro et al.   DEVELOPMENT

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate

(2018) Anke M. Smits et al.   PHARMACOLOGICAL RESEARCH

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

(2018) Matthew Wheelwright et al.   PLoS One

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly

(2018) Kyun Hoo Kim et al.   Cell Reports

Symmetry Breaking in the Mammalian Embryo

(2018) Hui Ting Zhang et al.   Annual Review of Cell and Developmental Biology

Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro

(2018) Masae Kobayashi et al.   Scientific Reports

A tissue-engineered scale model of the heart ventricle

(2018) Luke A. MacQueen et al.   Nature Biomedical Engineering

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

(2018) Jared M. Churko et al.   Nature Communications

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

(2017) Richard J. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny

(2016) Tracy A. Hookway et al.   METHODS

A strategy to discover new organizers identifies a putative heart organizer

(2016) Claire Anderson et al.   Nature Communications

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

(2016) Xiaoping Bao et al.   Nature Biomedical Engineering

Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine

(2015) Denise Al Alam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion

(2015) Hua Shen et al.   CARDIOVASCULAR RESEARCH

Contractile properties of developing human fetal cardiac muscle

(2015) Alice W. Racca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

(2015) Nathaniel Huebsch et al.   TISSUE ENGINEERING PART C-METHODS

Self-organizing human cardiac microchambers mediated by geometric confinement

(2015) Zhen Ma et al.   Nature Communications

Role of the Basement Membrane in Regulation of Cardiac Electrical Properties

(2014) Huaxiao Yang et al.   ANNALS OF BIOMEDICAL ENGINEERING

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry

(2014) Francesca Rochais et al.   CARDIOVASCULAR RESEARCH

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

(2014) Philippe Chetaille et al.   NATURE GENETICS

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

(2014) W Patrick Devine et al.   eLife

Microscale Generation of Cardiospheres Promotes Robust Enrichment of Cardiomyocytes Derived from Human Pluripotent Stem Cells

(2014) Doan C. Nguyen et al.   Stem Cell Reports

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease

(2013) Irina A. Sergeeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

(2013) Scott D. Lundy et al.   STEM CELLS AND DEVELOPMENT

Extracellular matrix as an inductive scaffold for functional tissue reconstruction

(2013) Bryan N. Brown et al.   Translational Research

GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data

(2012) Jianxing Feng et al.   BIOINFORMATICS

Not just inductive: a crucial mechanical role for the endoderm during heart tube assembly

(2012) V. D. Varner et al.   DEVELOPMENT

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Direct Contact with Endoderm-Like Cells Efficiently Induces Cardiac Progenitors from Mouse and Human Pluripotent Stem Cells

(2012) Hideki Uosaki et al.   PLoS One

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells

(2011) Nan Cao et al.   CELL RESEARCH

Signaling During Epicardium and Coronary Vessel Development

(2011) José María Pérez-Pomares et al.   CIRCULATION RESEARCH

eXtraembryonic ENdoderm (XEN) Stem Cells Produce Factors that Activate Heart Formation

(2010) Kemar Brown et al.   PLoS One

Fibroblast Growth Factor-10 Promotes Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells

(2010) Sunny Sun-Kin Chan et al.   PLoS One

Gata4 directs development of cardiac-inducing endoderm from ES cells

(2009) Audrey Holtzinger et al.   DEVELOPMENTAL BIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE