Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

(2021) Fotios Sampaziotis et al.   SCIENCE

Human Bile Contains Cholangiocyte Organoid-Initiating Cells Which Expand as Functional Cholangiocytes in Non-canonical Wnt Stimulating Conditions

(2021) Floris J. M. Roos et al.   Frontiers in Cell and Developmental Biology

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

(2021) Ary Marsee et al.   Cell Stem Cell

From Shape to Function: The Next Step in Bioprinting

(2020) Riccardo Levato et al.   ADVANCED MATERIALS

Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids

(2020) Melanie Krüger et al.   Advanced Healthcare Materials

Towards improved hepatocyte cultures: Progress and limitations

(2020) Marc Ruoß et al.   FOOD AND CHEMICAL TOXICOLOGY

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

(2020) Andrea Schwab et al.   CHEMICAL REVIEWS

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Prime editing for functional repair in patient-derived disease models

(2020) Imre F. Schene et al.   Nature Communications

Biofabrication of Hepatic Constructs by 3D Bioprinting of a Cell‐Laden Thermogel: An Effective Tool to Assess Drug‐Induced Hepatotoxic Response

(2020) Manuele Gori et al.   Advanced Healthcare Materials

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

(2020) Kynan T. Lawlor et al.   NATURE MATERIALS

Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity

(2019) Jaehwan Ahn et al.   Journal of Biological Engineering

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

(2019) Alison J. Foster et al.   ARCHIVES OF TOXICOLOGY

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells

(2019) Alexander K. Nguyen et al.   Biointerphases

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

(2019) Volker M. Lauschke et al.   Biotechnology Journal

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

(2019) Lara Planas-Paz et al.   Cell Stem Cell

Liver Microphysiological Systems for Predicting and Evaluating Drug Effects

(2019) Alexandre J.S. Ribeiro et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human Organoids: Tools for Understanding Biology and Treating Diseases

(2019) Frans Schutgens et al.   Annual Review of Pathology-Mechanisms of Disease

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

(2019) Barbara J. Klotz et al.   Advanced Healthcare Materials

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

(2019) Yitian Zhou et al.   Frontiers in Pharmacology

Large‐scale Production of LGR5‐positive Bipotential Human Liver Stem Cells

(2019) Kerstin Schneeberger et al.   HEPATOLOGY

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

(2018) Chen Chen et al.   GASTROENTEROLOGY

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

(2018) Jieyu Xu et al.   TOXICOLOGY IN VITRO

Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications

(2018) Tobias Grix et al.   Genes

Organoids for Drug Discovery and Personalized Medicine

(2018) Toshio Takahashi   Annual Review of Pharmacology and Toxicology

Animal models of drug-induced liver injury

(2018) Mitchell R. McGill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture

(2018) Xuanyi Ma et al.   BIOMATERIALS

Microfluidic cell culture platforms to capture hepatic physiology and complex cellular interactions

(2018) Shyam Sundhar Bale et al.   DRUG METABOLISM AND DISPOSITION

Advanced In Vitro HepaRG Culture Systems for Xenobiotic Metabolism and Toxicity Characterization

(2018) Muhammad Nadeem Ashraf et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies

(2018) Thomas Hiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

(2017) Hedwig S. Kruitwagen et al.   Stem Cell Reports

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

(2016) Sanja Dragovic et al.   ARCHIVES OF TOXICOLOGY

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries

(2016) Doshi Utkarsh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry

(2016) Natalia Davidenko et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

(2016) Barbara J. Klotz et al.   TRENDS IN BIOTECHNOLOGY

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

(2016) Christine Lin et al.   Biomed Research International

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Strategies and Molecular Design Criteria for 3D Printable Hydrogels

(2015) Tomasz Jungst et al.   CHEMICAL REVIEWS

Preventing Drug-Induced Liver Injury: How Useful Are Animal Models?

(2015) François Ballet   DIGESTIVE DISEASES

WITHDRAWN—a resource for withdrawn and discontinued drugs

(2015) Vishal B. Siramshetty et al.   NUCLEIC ACIDS RESEARCH

Matrigel: From discovery and ECM mimicry to assays and models for cancer research

(2014) Gabriel Benton et al.   ADVANCED DRUG DELIVERY REVIEWS

Competency of different cell models to predict human hepatotoxic drugs

(2014) M José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels

(2014) Luiz E Bertassoni et al.   Biofabrication

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Gelatin-Methacrylamide Hydrogels as Potential Biomaterials for Fabrication of Tissue-Engineered Cartilage Constructs

(2013) Wouter Schuurman et al.   MACROMOLECULAR BIOSCIENCE

Altered Subcellular Localization of Heat Shock Protein 90 Is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs

(2013) Frank G. van Steenbeek et al.   PLoS One

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

(2012) J. Fraczek et al.   ARCHIVES OF TOXICOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip

(2011) J E Snyder et al.   Biofabrication

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

Polymorphism of human cytochrome P450 enzymes and its clinical impact

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE