Organoids, Assembloids, and Novel Biotechnology: Steps Forward in Developmental and Disease-Related Neuroscience

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

(2020) Annie Kathuria et al.   Genome Medicine

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts

(2020) Dongchang Xiao et al.   Science Advances

Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells

(2020) Xingru Li et al.   Cancers

Research and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions

(2020) Sergiu P. Paşca et al.   MOLECULAR PSYCHIATRY

Immortalized Dorsal Root Ganglion Neuron Cell Lines

(2020) Rainer Viktor Haberberger et al.   Frontiers in Cellular Neuroscience

Assembling human brain organoids

(2019) Sergiu P. Paşca   SCIENCE

Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma

(2019) Sougat Misra et al.   Scientific Reports

Induced pluripotent stem cells in disease modelling and drug discovery

(2019) R. Grant Rowe et al.   NATURE REVIEWS GENETICS

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

Development of drug-inducible CRISPR-Cas9 systems for large-scale functional screening

(2019) Ning Sun et al.   BMC GENOMICS

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

(2019) Ana C. F. Bolhaqueiro et al.   NATURE GENETICS

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Genetic Causes and Modifiers of Autism Spectrum Disorder

(2019) Lauren Rylaarsdam et al.   Frontiers in Cellular Neuroscience

Principles of Optogenetic Methods and Their Application to Cardiac Experimental Systems

(2019) Emily A. Ferenczi et al.   Frontiers in Physiology

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery

(2019) Ramya Sivakumar et al.   OncoImmunology

Patient and Disease–Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics

(2019) David T. Paik et al.   PHARMACOLOGICAL REVIEWS

Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease

(2019) Rebecca M. Marton et al.   TRENDS IN CELL BIOLOGY

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

Drug screening for human genetic diseases using iPSC models

(2018) Matthew S Elitt et al.   HUMAN MOLECULAR GENETICS

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy

(2018) Marie Held et al.   PLoS One

An ex vivo Tissue Culture Model for the Assessment of Individualized Drug Responses in Prostate and Bladder Cancer

(2018) Arjanneke F. van de Merbel et al.   Frontiers in Oncology

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Genome engineering of stem cell organoids for disease modeling

(2017) Yingmin Sun et al.   Protein & Cell

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions

(2016) William T. Hendriks et al.   Cell Stem Cell

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

(2016) Martti Maimets et al.   Stem Cell Reports

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Induced Pluripotent Stem Cells for Regenerative Medicine

(2014) Karen K. Hirschi et al.   Annual Review of Biomedical Engineering

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Impaired thalamocortical connectivity in autism spectrum disorder: a study of functional and anatomical connectivity

(2013) Aarti Nair et al.   BRAIN

Human pluripotent stem cells: an emerging model in developmental biology

(2013) Z. Zhu et al.   DEVELOPMENT

Genome editing of human pluripotent stem cells to generate human cellular disease models

(2013) K. Musunuru   Disease Models & Mechanisms

Parvalbumin-Expressing Inhibitory Interneurons in Auditory Cortex Are Well-Tuned for Frequency

(2013) A. K. Moore et al.   JOURNAL OF NEUROSCIENCE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Intracortical multiplication of thalamocortical signals in mouse auditory cortex

(2013) Ling-yun Li et al.   NATURE NEUROSCIENCE

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

(2012) Qiurong Ding et al.   Cell Stem Cell

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Induced pluripotent stem cells for retinal degenerative diseases: a new perspective on the challenges

(2010) Zi-Bing Jin et al.   JOURNAL OF GENETICS

In vivo visualization and functional characterization of primary somatic neurons

(2010) Chao Ma et al.   JOURNAL OF NEUROSCIENCE METHODS

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Epigenetic reprogramming and induced pluripotency

(2009) K. Hochedlinger et al.   DEVELOPMENT

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The paradox of model organisms. The use of model organisms in research will continue despite their shortcomings

(2008) Philip Hunter   EMBO REPORTS

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT