Advancing lung organoids for COVID-19 research

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

(2021) Anna Z Mykytyn et al.   eLife

The Variant Gambit: COVID’s Next Move

(2021) Jessica A. Plante et al.   Cell Host & Microbe

The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell–derived lung progenitors in 3D

(2021) Ana Luisa Rodrigues Toste de Carvalho et al.   Nature Protocols

In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic

(2021) Rafael B. Rosa et al.   Viruses-Basel

Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids

(2021) Shashi Kant Tiwari et al.   Stem Cell Reports

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

(2021) Mart M Lamers et al.   eLife

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review

(2020) Adrian V. Hernandez et al.   ANNALS OF INTERNAL MEDICINE

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

(2020) Jasper Fuk-Woo Chan et al.   CLINICAL INFECTIOUS DISEASES

Post‐mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction

(2020) T. Menter et al.   HISTOPATHOLOGY

Airway organoids as models of human disease

(2020) J. Vaart et al.   JOURNAL OF INTERNAL MEDICINE

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

and Animal Models for SARS-CoV-2 research

(2020) Kazuo Takayama   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection

(2020) Kei Haga et al.   mBio

In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells

(2020) Sander van Riet et al.   Scientific Reports

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

Identification of common deletions in the spike protein of SARS-CoV-2

(2020) Zhe Liu et al.   JOURNAL OF VIROLOGY

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

SARS-CoV-2 is transmitted via contact and via the air between ferrets

(2020) Mathilde Richard et al.   Nature Communications

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

(2020) Shulong Zu et al.   CELL RESEARCH

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

(2020) Jessie Huang et al.   Cell Stem Cell

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

(2020) Jeonghwan Youk et al.   Cell Stem Cell

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

(2020) Sarah R. Leist et al.   Disease Models & Mechanisms

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

(2020) William B. Klimstra et al.   JOURNAL OF GENERAL VIROLOGY

Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection

(2020) Gergely Tekes et al.   Cells

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

(2020) Mart M Lamers et al.   EMBO JOURNAL

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Oral mucosal organoids as a potential platform for personalized cancer therapy

(2019) Else Driehuis et al.   Cancer Discovery

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges

(2019) Mary K. Estes et al.   Viruses-Basel

Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells

(2019) Anjali Jacob et al.   Nature Protocols

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture

(2018) Ana Luisa Rodrigues Toste de Carvalho et al.   DEVELOPMENT

Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses

(2018) Gabriela Alvarado et al.   GASTROENTEROLOGY

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

(2017) Marko Z Nikolić et al.   eLife

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

(2016) Satoshi Konishi et al.   Stem Cell Reports

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells

(2014) A. L. Firth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Breaking theIn VitroAlveolar Type II Cell Proliferation Barrier while Retaining Ion Transport Properties

(2013) Peter F. Bove et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

Expansive Generation of Functional Airway Epithelium From Human Embryonic Stem Cells

(2013) Brendan A.S. McIntyre et al.   Stem Cells Translational Medicine

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

(2012) Hongmei Mou et al.   Cell Stem Cell