Current Challenges and Controversies in Drug-Induced Liver Injury

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

(2012) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of Drug-Induced Serious Hepatotoxicity (eDISH)

(2011) Paul B. Watkins et al.   DRUG SAFETY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

(2011) Jingtao Lu et al.   TOXICOLOGICAL SCIENCES

The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports

(2010) L. LLANOS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

(2010) H. Cai et al.   DRUG METABOLISM AND DISPOSITION

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

A Mouse Model of Severe Halothane Hepatitis Based on Human Risk Factors

(2010) C. M. Dugan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury

(2010) Frank Dieterle et al.   NATURE BIOTECHNOLOGY

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

(2010) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies

(2010) M. Adler et al.   TOXICOLOGY LETTERS

Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages

(2010) Tokuo Sukata et al.   TOXICOLOGY LETTERS

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury

(2009) O. F. Laterza et al.   CLINICAL CHEMISTRY

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Diagnosis, management and prevention of drug-induced liver injury

(2009) S Verma et al.   GUT

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

Sulindac Metabolism and Synergy with Tumor Necrosis Factor-  in a Drug-Inflammation Interaction Model of Idiosyncratic Liver Injury

(2009) W. Zou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Trovafloxacin Enhances the Inflammatory Response to a Gram-Negative or a Gram-Positive Bacterial Stimulus, Resulting in Neutrophil-Dependent Liver Injury in Mice

(2009) P. J. Shaw et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity--Two Villains or One?

(2009) R. A. Roth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-induced liver injury: insights from genetic studies

(2009) Raúl J Andrade et al.   PHARMACOGENOMICS

Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models

(2009) X. Deng et al.   PHARMACOLOGICAL REVIEWS

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury

(2009) Josef S. Ozer et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity

(2009) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability

(2009) Patrick J. Shaw et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

(2009) Benjamin D. Cosgrove et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impact of biomarker development on drug safety assessment

(2009) Estelle Marrer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Drug-induced hepatotoxicity test using γ-glutamylcysteine synthetase knockdown rat

(2009) Mayu Morita et al.   TOXICOLOGY LETTERS

Measurement of serum paraoxonase-1 activity in the evaluation of liver function

(2009) Jordi Camps et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

(2009) D.J. Antoine et al.   XENOBIOTICA

Review article: the use of potentially hepatotoxic drugs in patients with liver disease

(2008) N. K. GUPTA et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent Metabolism

(2008) S Muruganandan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

(2008) Roger K. Verbeeck   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A problem-oriented approach to liver disease in oncology patients

(2008) G B McDonald et al.   GUT

Effect of polyI:C cotreatment on halothane-induced liver injury in mice

(2008) Linling Cheng et al.   HEPATOLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment

(2008) C. Cheung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tumor Necrosis Factor  Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure

(2008) P. J. Shaw et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat

(2008) Mark R. Fielden et al.   TOXICOLOGICAL SCIENCES

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

(2008) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Hepatotoxic Interaction of Sulindac with Lipopolysaccharide: Role of the Hemostatic System

(2008) Wei Zou et al.   TOXICOLOGICAL SCIENCES

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury

(2008) Yie Hou Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver

(2008) N.A.G. Santos et al.   TOXICOLOGY IN VITRO

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY