Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment

Human Embryonic Stem Cell-Derived Wilson’s Disease Model for Screening Drug Efficacy

(2020) Dongkyu Kim et al.   Cells

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

(2020) Tadahiro Shinozawa et al.   GASTROENTEROLOGY

Polygenic architecture informs potential vulnerability to drug-induced liver injury

(2020) Masaru Koido et al.   NATURE MEDICINE

Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2

(2019) Bo Zhou et al.   NUCLEIC ACIDS RESEARCH

Technological advancements for the development of stem cell-based models for hepatotoxicity testing

(2019) Alessandra Natale et al.   ARCHIVES OF TOXICOLOGY

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

(2019) Rie Ouchi et al.   Cell Metabolism

Liver organoids: from basic research to therapeutic applications

(2019) Nicole Prior et al.   GUT

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

(2019) Seon Ju Mun et al.   JOURNAL OF HEPATOLOGY

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

(2019) Shuyong Wang et al.   CELL RESEARCH

Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling

(2019) Soheil Akbari et al.   Stem Cell Reports

Animal models of biliary injury and altered bile acid metabolism

(2018) Valeria Mariotti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis

(2018) Kia M. Peters et al.   CURRENT OPINION IN LIPIDOLOGY

Role of cytochrome P450 enzymes in fimasartan metabolism in vitro

(2018) Young Jae Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

(2018) Sabine U Vorrink et al.   TOXICOLOGICAL SCIENCES

Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells

(2018) Yohan Kim et al.   JOURNAL OF HEPATOLOGY

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens

(2018) Gong-Bo Fu et al.   CELL RESEARCH

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Ferric Citrate Supplementation Reduces Red-Blood-Cell Aggregation and Improves CD163+ Macrophage-Mediated Hemoglobin Metabolism in a Rat Model of High-Fat-Diet-Induced Obesity

(2017) Ting-Yun Chang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease?

(2016) Wonhyo Seo   WORLD JOURNAL OF GASTROENTEROLOGY

Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

(2016) Hye-Min Kim et al.   Scientific Reports

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

(2016) Nancy Magee et al.   Biomed Research International

EpCAM and the biology of hepatic stem/progenitor cells

(2015) Laurent Dollé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Wilson’s Disease: A Comprehensive Review of the Molecular Mechanisms

(2015) Fei Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

(2015) Melissa Baxter et al.   JOURNAL OF HEPATOLOGY

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Characterization of fimasartan metabolites in human liver microsomes and human plasma

(2015) Ji-Yoon Lee et al.   XENOBIOTICA

EASL Clinical Practice Guidelines: Wilson’s disease

(2015)   JOURNAL OF HEPATOLOGY

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

(2015) Han-Jin Park et al.   PLoS One

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

(2014) Marc Bonder et al.   BMC GENOMICS

Efficacy and Safety of Oral Chelators in Treatment of Patients With Wilson Disease

(2013) Karl Heinz Weiss et al.   Clinical Gastroenterology and Hepatology

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

(2013) M. Kitade et al.   GENES & DEVELOPMENT

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

(2012) J. Fraczek et al.   ARCHIVES OF TOXICOLOGY

A Perspective on Efflux Transport Proteins in the Liver

(2012) K Köck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Review of Acetaminophen Poisoning

(2012) Michael J. Hodgman et al.   CRITICAL CARE CLINICS

Trientine-induced neurological deterioration in a patient with Wilson’s disease

(2012) Bomi Kim et al.   JOURNAL OF CLINICAL NEUROSCIENCE

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

(2011) A. DeLaForest et al.   DEVELOPMENT

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions

(2011) Kye Sook Lee et al.   JOURNAL OF APPLIED TOXICOLOGY

Liver stem/progenitor cells: their characteristics and regulatory mechanisms

(2011) M. Tanaka et al.   JOURNAL OF BIOCHEMISTRY

Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells

(2010) Josué Kunjom Mfopou et al.   GASTROENTEROLOGY

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes

(2010) Hua Liu et al.   HEPATOLOGY

Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver

(2009) Sei Kakinuma et al.   JOURNAL OF HEPATOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

(2008) A. Suzuki et al.   DEVELOPMENT

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Role of cytochrome P450 in drug interactions

(2008) Zakia Bibi   Nutrition & Metabolism