A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity

(2020) Catherine C. Bell et al.   ARCHIVES OF TOXICOLOGY

3D Spheroids with Primary Human Liver Cells and Differential Roles of Kupffer Cells in Drug-Induced Liver Injury

(2020) Feng Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

(2019) Alison J. Foster et al.   ARCHIVES OF TOXICOLOGY

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes.

(2019) Mihaela Zabulica et al.   STEM CELLS AND DEVELOPMENT

Engineering Tissues from Induced Pluripotent Stem Cells

(2019) Peter Loskill et al.   TISSUE ENGINEERING PART A

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

(2018) Catherine C Bell et al.   TOXICOLOGICAL SCIENCES

In vitro and in silico liver models: Current trends, challenges and opportunities

(2018) Andrey Poloznikov   ALTEX-Alternatives to Animal Experimentation

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy

(2017) Shannan R. Tujios et al.   LIVER INTERNATIONAL

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity

(2017) Shih-Yu Chang et al.   TOXICOLOGY IN VITRO

Erratum: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells

(2017) Yuta Koui et al.   Stem Cell Reports

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

(2016) Minjun Chen et al.   DRUG DISCOVERY TODAY

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments

(2016) Bo Wang et al.   Stem Cells Translational Medicine

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactionsin vitro

(2015) Dustin R. Berger et al.   HEPATOLOGY

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

(2015) Brenton R. Ware et al.   TOXICOLOGICAL SCIENCES

All-In-One: Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells

(2015) Melanie Werner et al.   PLoS One

Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells

(2014) Elisa Pfeiffer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Human Induced Pluripotent Stem Cells in Hepatology

(2013) Sabine Gerbal-Chaloin et al.   AMERICAN JOURNAL OF PATHOLOGY

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

(2013) A. Dash et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity

(2013) L. Schyschka et al.   ARCHIVES OF TOXICOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

The contribution of oxidative stress to drug-induced organ toxicity and its detectionin vitroandin vivo

(2012) Claudia V Pereira et al.   Expert Opinion on Drug Metabolism & Toxicology

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Phaseguides: a paradigm shift in microfluidic priming and emptying

(2011) Paul Vulto et al.   LAB ON A CHIP

Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism

(2010) Thomas A. Baillie et al.   Drug Metabolism and Pharmacokinetics

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES