Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
Authors
Keywords
-
Journal
Nature Communications
Volume 14, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-01-13
DOI
10.1038/s41467-023-35886-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution
- (2022) Liudan Jiang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
- (2022) Philipp Reautschnig et al. NATURE BIOTECHNOLOGY
- Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo
- (2022) Zongyi Yi et al. NATURE BIOTECHNOLOGY
- Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs
- (2022) Dhruva Katrekar et al. NATURE BIOTECHNOLOGY
- Genome-wide detection of CRISPR editing in vivo using GUIDE-tag
- (2022) Shun-Qing Liang et al. Nature Communications
- Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity
- (2022) Rongjie Fu et al. Nature Communications
- Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair
- (2022) J. Ferreira da Silva et al. Nature Communications
- Targeted gene silencing in the nervous system with CRISPR-Cas13
- (2022) Jackson E. Powell et al. Science Advances
- The origin of unwanted editing byproducts in gene editing
- (2022) Jianhang Yin et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Structural basis for mismatch surveillance by CRISPR–Cas9
- (2022) Jack P. K. Bravo et al. NATURE
- Mitochondrial base editor induces substantial nuclear off-target mutations
- (2022) Zhixin Lei et al. NATURE
- A split prime editor with untethered reverse transcriptase and circular RNA template
- (2022) Bin Liu et al. NATURE BIOTECHNOLOGY
- An engineered prime editor with enhanced editing efficiency in plants
- (2022) Yuan Zong et al. NATURE BIOTECHNOLOGY
- Efficient targeted insertion of large DNA fragments without DNA donors
- (2022) Jinlin Wang et al. NATURE METHODS
- AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns
- (2022) Yanhui Liang et al. NUCLEIC ACIDS RESEARCH
- Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure
- (2022) Xiaosa Li et al. Nature Communications
- Mutation-specific reporter for optimization and enrichment of prime editing
- (2022) I. F. Schene et al. Nature Communications
- Enhancement of prime editing via xrRNA motif-joined pegRNA
- (2022) Guiquan Zhang et al. Nature Communications
- CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
- (2022) Ida Höijer et al. Nature Communications
- A systematic review and meta-analysis of gene therapy with hematopoietic stem and progenitor cells for monogenic disorders
- (2022) Francesca Tucci et al. Nature Communications
- Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
- (2022) Martin Peterka et al. Nature Communications
- Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
- (2022) Jianhang Yin et al. Nature Communications
- PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells
- (2022) Dorottya Anna Simon et al. eLife
- Regulatory Considerations for Clinical Trial Applications with CRISPR-Based Medicinal Products
- (2022) Brigitte Anliker et al. CRISPR Journal
- Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors
- (2022) Runze Gao et al. CRISPR Journal
- High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation
- (2022) Wendy Magis et al. iScience
- Therapeutic in vivo delivery of gene editing agents
- (2022) Aditya Raguram et al. CELL
- High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
- (2022) Huawei Tong et al. NATURE BIOTECHNOLOGY
- Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage
- (2022) Alessio David Nahmad et al. NATURE BIOTECHNOLOGY
- CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia
- (2022) Bin Fu et al. NATURE MEDICINE
- Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial
- (2022) Kevin A. Strauss et al. NATURE MEDICINE
- Designing and executing prime editing experiments in mammalian cells
- (2022) Jordan L. Doman et al. Nature Protocols
- Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells
- (2022) Rui Tao et al. NUCLEIC ACIDS RESEARCH
- Cas9-induced large deletions and small indels are controlled in a convergent fashion
- (2022) Michael Kosicki et al. Nature Communications
- Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq
- (2022) Felix M. Dobbs et al. Nature Communications
- Cytosine base editing systems with minimized off-target effect and molecular size
- (2022) Ang Li et al. Nature Communications
- Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
- (2022) Jianli Tao et al. Nature Communications
- Massively targeted evaluation of therapeutic CRISPR off-targets in cells
- (2022) Xiaoguang Pan et al. Nature Communications
- Peptide fusion improves prime editing efficiency
- (2022) Minja Velimirovic et al. Nature Communications
- Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs
- (2022) Ying Feng et al. Protein & Cell
- Systematicidentification of CRISPR off-target effects by CROss-seq
- (2022) Yan Li et al. Protein & Cell
- Current Outline of Exon Skipping Trials in Duchenne Muscular Dystrophy
- (2022) Gökçe Eser et al. Genes
- Structural basis for Cas9 off-target activity
- (2022) Martin Pacesa et al. CELL
- Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells
- (2022) Keyi Geng et al. GENOME RESEARCH
- Targeted genomic translocations and inversions generated using a paired prime editing strategy
- (2022) Jiyeon Kweon et al. MOLECULAR THERAPY
- R-loop formation and conformational activation mechanisms of Cas9
- (2022) Martin Pacesa et al. NATURE
- Engineered CRISPR prime editors with compact, untethered reverse transcriptases
- (2022) Julian Grünewald et al. NATURE BIOTECHNOLOGY
- Engineering a precise adenine base editor with minimal bystander editing
- (2022) Liang Chen et al. Nature Chemical Biology
- CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo
- (2022) Jinchun Wu et al. NUCLEIC ACIDS RESEARCH
- Marker-free co-selection for successive rounds of prime editing in human cells
- (2022) Sébastien Levesque et al. Nature Communications
- Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells
- (2022) Mu Li et al. Nature Communications
- Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
- (2022) Changchang Xin et al. Nature Communications
- Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
- (2022) Tao Wan et al. Science Advances
- Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing
- (2022) So Hyun Park et al. Science Advances
- CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
- (2022) Jinghui Song et al. MOLECULAR CELL
- Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
- (2022) Liang Chen et al. NATURE BIOTECHNOLOGY
- Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
- (2022) Monica E. Neugebauer et al. NATURE BIOTECHNOLOGY
- Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
- (2022) Matthew T. N. Yarnall et al. NATURE BIOTECHNOLOGY
- Prime editing for precise and highly versatile genome manipulation
- (2022) Peter J. Chen et al. NATURE REVIEWS GENETICS
- Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
- (2022) Jianhang Yin et al. Nature Communications
- PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation
- (2022) Zhenxing Yu et al. Nature Communications
- SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e
- (2022) Péter István Kulcsár et al. Nature Communications
- TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor
- (2022) Jeonghun Kwon et al. Nature Communications
- CRISPR technologies and the search for the PAM-free nuclease
- (2021) Daphne Collias et al. Nature Communications
- Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
- (2021) Giandomenico Turchiano et al. Cell Stem Cell
- Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents
- (2021) Emmeline L. Blanchard et al. NATURE BIOTECHNOLOGY
- Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
- (2021) Liwei Chen et al. Nature Communications
- Neuronal enhancers are hotspots for DNA single-strand break repair
- (2021) Wei Wu et al. NATURE
- High-efficiency prime editing with optimized, paired pegRNAs in plants
- (2021) Qiupeng Lin et al. NATURE BIOTECHNOLOGY
- Genome-wide specificity of prime editors in plants
- (2021) Shuai Jin et al. NATURE BIOTECHNOLOGY
- Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations
- (2021) Lijie Wang et al. NATURE CELL BIOLOGY
- Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
- (2021) Mitchell L. Leibowitz et al. NATURE GENETICS
- Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
- (2021) Jianan Li et al. Nature Communications
- Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
- (2021) Pengpeng Liu et al. Nature Communications
- Base-Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase
- (2021) Yafen Wang et al. ACS Central Science
- Perfecting Targeting in CRISPR
- (2021) Hainan Zhang et al. Annual Review of Genetics
- Somatic mosaicism in inherited bone marrow failure syndromes
- (2021) Fernanda Gutierrez-Rodrigues et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
- (2021) Luke W. Koblan et al. NATURE BIOTECHNOLOGY
- Retrieval of vector integration sites from cell-free DNA
- (2021) Daniela Cesana et al. NATURE MEDICINE
- Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors
- (2021) Zhixin Lei et al. NATURE METHODS
- CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
- (2021) Julian D. Gillmore et al. NEW ENGLAND JOURNAL OF MEDICINE
- Optimized nickase- and nuclease-based prime editing in human and mouse cells
- (2021) Fatwa Adikusuma et al. NUCLEIC ACIDS RESEARCH
- Global detection of DNA repair outcomes induced by CRISPR–Cas9
- (2021) Mengzhu Liu et al. NUCLEIC ACIDS RESEARCH
- Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods
- (2021) Tanglong Yuan et al. Nature Communications
- Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning
- (2021) Xi Xiang et al. Nature Communications
- Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
- (2021) Myungjae Song et al. Nature Communications
- CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
- (2021) J. Boutin et al. Nature Communications
- Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
- (2021) Peter J. Chen et al. CELL
- Unexpected gene activation following CRISPR‐Cas9‐mediated genome editing
- (2021) Anna G Manjón et al. EMBO REPORTS
- Deletion and replacement of long genomic sequences using prime editing
- (2021) Tingting Jiang et al. NATURE BIOTECHNOLOGY
- Engineered pegRNAs improve prime editing efficiency
- (2021) James W. Nelson et al. NATURE BIOTECHNOLOGY
- Precise genomic deletions using paired prime editing
- (2021) Junhong Choi et al. NATURE BIOTECHNOLOGY
- Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
- (2021) Andrew V. Anzalone et al. NATURE BIOTECHNOLOGY
- Increasing the efficiency and precision of prime editing with guide RNA pairs
- (2021) Yuan Zhuang et al. Nature Chemical Biology
- Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease
- (2021) Sunita Goyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
- (2021) Stamatis Papathanasiou et al. Nature Communications
- The promise and challenge of therapeutic genome editing
- (2020) Jennifer A. Doudna NATURE
- Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors
- (2020) Chao Li et al. NATURE BIOTECHNOLOGY
- Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
- (2020) Jordan L. Doman et al. NATURE BIOTECHNOLOGY
- Template plasmid integration in germline genome-edited cattle
- (2020) Alexis L. Norris et al. NATURE BIOTECHNOLOGY
- RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering
- (2020) Aaron A. Smargon et al. NATURE CELL BIOLOGY
- Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
- (2020) Majda Bratovič et al. Nature Chemical Biology
- Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9–mediated genome editing events
- (2020) Boris V. Skryabin et al. Science Advances
- ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing
- (2020) Camilo Breton et al. BMC GENOMICS
- Highly Parallel Profiling of Cas9 Variant Specificity
- (2020) Jonathan L. Schmid-Burgk et al. MOLECULAR CELL
- Prime genome editing in rice and wheat
- (2020) Qiupeng Lin et al. NATURE BIOTECHNOLOGY
- Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
- (2020) Michelle F. Richter et al. NATURE BIOTECHNOLOGY
- Dual base editor catalyzes both cytosine and adenine base conversions in human cells
- (2020) Xiaohui Zhang et al. NATURE BIOTECHNOLOGY
- A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
- (2020) Julian Grünewald et al. NATURE BIOTECHNOLOGY
- Base editors for simultaneous introduction of C-to-T and A-to-G mutations
- (2020) Rina C. Sakata et al. NATURE BIOTECHNOLOGY
- Cas9 activates the p53 pathway and selects for p53-inactivating mutations
- (2020) Oana M. Enache et al. NATURE GENETICS
- Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer
- (2020) You Lu et al. NATURE MEDICINE
- Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ
- (2020) Tong Wu et al. NATURE METHODS
- Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs
- (2020) John C. Rose et al. Nature Communications
- Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
- (2020) Yi Yu et al. Nature Communications
- Multiplexed CRISPR technologies for gene editing and transcriptional regulation
- (2020) Nicholas S. McCarty et al. Nature Communications
- Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity
- (2020) Shuai Jin et al. MOLECULAR CELL
- A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
- (2020) Beverly Y. Mok et al. NATURE
- Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
- (2020) Andrew V. Anzalone et al. NATURE BIOTECHNOLOGY
- CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
- (2020) Cicera R. Lazzarotto et al. NATURE BIOTECHNOLOGY
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
- (2020) Ibrahim C. Kurt et al. NATURE BIOTECHNOLOGY
- Glycosylase base editors enable C-to-A and C-to-G base changes
- (2020) Dongdong Zhao et al. NATURE BIOTECHNOLOGY
- Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects
- (2020) Sangsin Lee et al. Science Advances
- Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease
- (2020) Matthew M. Hsieh et al. Blood Advances
- ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems
- (2020) Jingke Xie et al. BMC BIOLOGY
- Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing
- (2020) Julia Joung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Unbiased investigation of specificities of prime editing systems in human cells
- (2020) Do Yon Kim et al. NUCLEIC ACIDS RESEARCH
- POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks
- (2020) Luther Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prime editing for functional repair in patient-derived disease models
- (2020) Imre F. Schene et al. Nature Communications
- CRISPRoff enables spatio-temporal control of CRISPR editing
- (2020) Jared Carlson-Stevermer et al. Nature Communications
- CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
- (2020) Matthew A. Coelho et al. Nature Communications
- Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments
- (2020) Hajnalka L Pálinkás et al. eLife
- Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos
- (2020) Michael V. Zuccaro et al. CELL
- Tools for experimental and computational analyses of off-target editing by programmable nucleases
- (2020) X. Robert Bao et al. Nature Protocols
- CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
- (2020) Haydar Frangoul et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Cas-embedding strategy for minimizing off-target effects of DNA base editors
- (2020) Yajing Liu et al. Nature Communications
- MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits
- (2020) Linyuan Ma et al. Nature Communications
- Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
- (2019) Morgan L. Maeder et al. NATURE MEDICINE
- Genome-wide profiling of adenine base editor specificity by EndoV-seq
- (2019) Puping Liang et al. Nature Communications
- Optimizing genome editing strategy by primer-extension-mediated sequencing
- (2019) Jianhang Yin et al. Cell Discovery
- CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
- (2019) Grégoire Cullot et al. Nature Communications
- Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
- (2019) Erwei Zuo et al. SCIENCE
- Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice
- (2019) Shuai Jin et al. SCIENCE
- Genome-wide target specificity of CRISPR RNA-guided adenine base editors
- (2019) Daesik Kim et al. NATURE BIOTECHNOLOGY
- Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
- (2019) Tobias Merkle et al. NATURE BIOTECHNOLOGY
- Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
- (2019) Giulia Schiroli et al. Cell Stem Cell
- CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture
- (2019) Kunling Chen et al. Annual Review of Plant Biology
- Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
- (2019) Daesik Kim et al. Annual Review of Biochemistry
- Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
- (2019) Julian Grünewald et al. NATURE
- The next generation of CRISPR–Cas technologies and applications
- (2019) Adrian Pickar-Oliver et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Analysis and minimization of cellular RNA editing by DNA adenine base editors
- (2019) Holly A. Rees et al. Science Advances
- Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
- (2019) Changyang Zhou et al. NATURE
- Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration
- (2019) Sanne E. Klompe et al. NATURE
- Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs
- (2019) Liang Qu et al. NATURE BIOTECHNOLOGY
- RNA-guided DNA insertion with CRISPR-associated transposases
- (2019) Jonathan Strecker et al. SCIENCE
- A cytosine deaminase for programmable single-base RNA editing
- (2019) Omar O. Abudayyeh et al. SCIENCE
- CRISPR DNA base editors with reduced RNA off-target and self-editing activities
- (2019) Julian Grünewald et al. NATURE BIOTECHNOLOGY
- Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice
- (2019) Wen Xu et al. BMC PLANT BIOLOGY
- Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing
- (2019) Ramin Sakhtemani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Expanding C–T base editing toolkit with diversified cytidine deaminases
- (2019) Tian-Lin Cheng et al. Nature Communications
- High levels of AAV vector integration into CRISPR-induced DNA breaks
- (2019) Killian S. Hanlon et al. Nature Communications
- Advances in genome editing through control of DNA repair pathways
- (2019) Charles D. Yeh et al. NATURE CELL BIOLOGY
- UDiTaS™, a genome editing detection method for indels and genome rearrangements
- (2018) Georgia Giannoukos et al. BMC GENOMICS
- Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
- (2018) Silvana Konermann et al. CELL
- Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion
- (2018) Jia Shou et al. MOLECULAR CELL
- Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34 + Hematopoietic Stem and Progenitor Cells
- (2018) M. Kyle Cromer et al. MOLECULAR THERAPY
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
- (2018) Michael Kosicki et al. NATURE BIOTECHNOLOGY
- Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
- (2018) Luke W Koblan et al. NATURE BIOTECHNOLOGY
- A highly specific SpCas9 variant is identified by in vivo screening in yeast
- (2018) Antonio Casini et al. NATURE BIOTECHNOLOGY
- Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA
- (2018) Xiaoting Shu et al. Nature Chemical Biology
- p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
- (2018) Robert J. Ihry et al. NATURE MEDICINE
- CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
- (2018) Emma Haapaniemi et al. NATURE MEDICINE
- Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
- (2018) Jonathan S. Gootenberg et al. SCIENCE
- Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
- (2018) Christopher R. Cromwell et al. Nature Communications
- Large deletions induced by Cas9 cleavage
- (2018) Fatwa Adikusuma et al. NATURE
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
- (2018) Jason M Gehrke et al. NATURE BIOTECHNOLOGY
- A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
- Directed evolution of CRISPR-Cas9 to increase its specificity
- (2018) Jungjoon K. Lee et al. Nature Communications
- DIG-seq: a genome-wide CRISPR off-target profiling method using chromatin DNA
- (2018) Daesik Kim et al. GENOME RESEARCH
- CRISPR-Based Technologies: Impact of RNA-Targeting Systems
- (2018) Michael P. Terns MOLECULAR CELL
- Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
- (2018) Yang Yu et al. NATURE
- Base editing: precision chemistry on the genome and transcriptome of living cells
- (2018) Holly A. Rees et al. NATURE REVIEWS GENETICS
- RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
- (2017) Alexandra East-Seletsky et al. MOLECULAR CELL
- Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
- (2017) Mara Compagno et al. NATURE
- Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
- (2017) Janice S. Chen et al. NATURE
- RNA targeting with CRISPR–Cas13
- (2017) Omar O. Abudayyeh et al. NATURE
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Genome-wide target specificities of CRISPR RNA-guided programmable deaminases
- (2017) Daesik Kim et al. NATURE BIOTECHNOLOGY
- Mapping the genomic landscape of CRISPR–Cas9 cleavage
- (2017) Peter Cameron et al. NATURE METHODS
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- Improving CRISPR–Cas specificity with chemical modifications in single-guide RNAs
- (2017) Daniel E Ryan et al. NUCLEIC ACIDS RESEARCH
- CUT-PCR: CRISPR-mediated, ultrasensitive detection of target DNA using PCR
- (2017) S H Lee et al. ONCOGENE
- RNA editing with CRISPR-Cas13
- (2017) David B. T. Cox et al. SCIENCE
- Nucleic acid detection with CRISPR-Cas13a/C2c2
- (2017) Jonathan S. Gootenberg et al. SCIENCE
- Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
- (2017) Holly A. Rees et al. Nature Communications
- BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
- (2017) Winston X. Yan et al. Nature Communications
- Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
- (2017) Alexis C. Komor et al. Science Advances
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
- (2017) Kunwoo Lee et al. Nature Biomedical Engineering
- DNA Breaks and End Resection Measured Genome-wide by End Sequencing
- (2016) Andres Canela et al. MOLECULAR CELL
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
- (2016) Alexandra East-Seletsky et al. NATURE
- DSBCapture: in situ capture and sequencing of DNA breaks
- (2016) Stefanie V Lensing et al. NATURE METHODS
- Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing
- (2016) Jiazhi Hu et al. Nature Protocols
- Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
- (2016) K. Nishida et al. SCIENCE
- C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
- (2016) Omar O. Abudayyeh et al. SCIENCE
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
- (2015) Xiaoling Wang et al. NATURE BIOTECHNOLOGY
- DNA-binding-domain fusions enhance the targeting range and precision of Cas9
- (2015) Mehmet Fatih Bolukbasi et al. NATURE METHODS
- Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
- (2015) Daesik Kim et al. NATURE METHODS
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- High resolution mapping of modified DNA nucleobases using excision repair enzymes
- (2014) D. Suzi Bryan et al. GENOME RESEARCH
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide
- (2014) Laura Baranello et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
- (2014) John A Zuris et al. NATURE BIOTECHNOLOGY
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
- (2014) Richard L Frock et al. NATURE BIOTECHNOLOGY
- Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
- (2014) Bin Shen et al. NATURE METHODS
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
- (2013) Prashant Mali et al. NATURE BIOTECHNOLOGY
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Efficient genome editing in zebrafish using a CRISPR-Cas system
- (2013) Woong Y Hwang et al. NATURE BIOTECHNOLOGY
- Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
- (2013) Nicola Crosetto et al. NATURE METHODS
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes
- (2011) Isaac A. Klein et al. CELL
- Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells
- (2011) Roberto Chiarle et al. CELL
- High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome
- (2010) Jason S Iacovoni et al. EMBO JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now