Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
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Title
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Authors
Keywords
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Journal
SCIENCE
Volume -, Issue -, Pages eaav9973
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-03-01
DOI
10.1126/science.aav9973
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- (2009) Linda Madisen et al. NATURE NEUROSCIENCE
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