Engineered CRISPR prime editors with compact, untethered reverse transcriptases

Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins

(2022) Renmei Liu et al.   NATURE BIOTECHNOLOGY

In vivo prime editing of a metabolic liver disease in mice

(2022) Desirée Böck et al.   Science Translational Medicine

Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

(2022) Xiaosa Li et al.   Nature Communications

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

(2021) Karl Petri et al.   NATURE BIOTECHNOLOGY

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

(2021) Pengpeng Liu et al.   Nature Communications

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

(2021) Peter J. Chen et al.   CELL

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

(2020) Jonathan M. Levy et al.   Nature Biomedical Engineering

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Multiple origins of reverse transcriptases linked to CRISPR-Cas systems

(2019) Nicolás Toro et al.   RNA Biology

Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase

(2019) Birgitta M. Wöhrl   Viruses-Basel

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications

(2017) Jennifer L. Stamos et al.   MOLECULAR CELL

An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron

(2017) Chen Zhao et al.   RNA

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution

(2016) Chen Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution

(2016) Chen Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy

(2015) M. Gramlich et al.   EMBO Molecular Medicine

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

(2015) Benjamin P Kleinstiver et al.   NATURE BIOTECHNOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Development of an intein-mediated split–Cas9 system for gene therapy

(2015) Dong-Jiunn Jeffery Truong et al.   NUCLEIC ACIDS RESEARCH

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing

(2013) S. Mohr et al.   RNA

Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture

(2012) N. Rohland et al.   GENOME RESEARCH

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase

(2008) Marie L. Coté et al.   VIRUS RESEARCH