Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

(2018) Zhengke Li et al.   EMBO JOURNAL

A Critical Role for Dna2 at Unwound Telomeres

(2018) Marta Markiewicz-Potoczny et al.   GENETICS

CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles

(2018) Brenda R. Lemos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Critical Role for Dna2 at Unwound Telomeres

(2018) Marta Markiewicz-Potoczny et al.   GENETICS

Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells

(2017) Bochao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

(2017) Kathrin Pieper et al.   NATURE

PGBD5 promotes site-specific oncogenic mutations in human tumors

(2017) Anton G Henssen et al.   NATURE GENETICS

Functional mapping of yeast genomes by saturated transposition

(2017) Agnès H Michel et al.   eLife

S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation

(2016) Lamia Wahba et al.   GENES & DEVELOPMENT

Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

(2016) Gizem Ölmezer et al.   Nature Communications

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

(2015) Young Seok Ju et al.   GENOME RESEARCH

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

The Conformation of Yeast Chromosome III Is Mating Type Dependent and Controlled by the Recombination Enhancer

(2015) Jon-Matthew Belton et al.   Cell Reports

Rad52/Rad59-dependent Recombination as a Means to Rectify Faulty Okazaki Fragment Processing

(2014) Miju Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

(2014) Miguel G. Blanco et al.   MOLECULAR CELL

Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome

(2014) M. Onozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

OriDB, the DNA replication origin database updated and extended

(2011) C. C. Siow et al.   NUCLEIC ACIDS RESEARCH

Pif1 Helicase Lengthens Some Okazaki Fragment Flaps Necessitating Dna2 Nuclease/Helicase Action in the Two-nuclease Processing Pathway

(2009) Jason E. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis

(2008) Carrie M. Stith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY