Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

(2022) J. Ferreira da Silva et al.   Nature Communications

Treatment by CRISPR-Cas9 Gene Editing — A Proof of Principle

(2021) Harry L. Malech   NEW ENGLAND JOURNAL OF MEDICINE

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

(2021) Gregory A. Newby et al.   NATURE

Global detection of DNA repair outcomes induced by CRISPR–Cas9

(2021) Mengzhu Liu et al.   NUCLEIC ACIDS RESEARCH

Unexpected gene activation following CRISPR‐Cas9‐mediated genome editing

(2021) Anna G Manjón et al.   EMBO REPORTS

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

(2021) Stamatis Papathanasiou et al.   Nature Communications

Template plasmid integration in germline genome-edited cattle

(2020) Alexis L. Norris et al.   NATURE BIOTECHNOLOGY

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

(2020) Daniel Ardeljan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prime Time for Genome Editing?

(2020) Fyodor D. Urnov   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9–mediated genome editing events

(2020) Boris V. Skryabin et al.   Science Advances

Prime genome editing in rice and wheat

(2020) Qiupeng Lin et al.   NATURE BIOTECHNOLOGY

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

(2020) Michelle F. Richter et al.   NATURE BIOTECHNOLOGY

Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer

(2020) You Lu et al.   NATURE MEDICINE

CRISPR off-target detection with DISCOVER-seq

(2020) Beeke Wienert et al.   Nature Protocols

CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity

(2020) Cicera R. Lazzarotto et al.   NATURE BIOTECHNOLOGY

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System

(2020) Jenny Shapiro et al.   Molecular Therapy-Methods & Clinical Development

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

(2020) Michael V. Zuccaro et al.   CELL

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

(2019) Grégoire Cullot et al.   Nature Communications

Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication

(2019) Diane A. Flasch et al.   CELL

The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection

(2019) Tania Sultana et al.   MOLECULAR CELL

Transposable elements in human genetic disease

(2019) Lindsay M. Payer et al.   NATURE REVIEWS GENETICS

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function

(2019) Emily M. Adney et al.   GENETICS

The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells

(2019) Ragini Bhargava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

High levels of AAV vector integration into CRISPR-induced DNA breaks

(2019) Killian S. Hanlon et al.   Nature Communications

Advances in genome editing through control of DNA repair pathways

(2019) Charles D. Yeh et al.   NATURE CELL BIOLOGY

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

(2018) Luke W Koblan et al.   NATURE BIOTECHNOLOGY

Inducing CCR5Δ32/Δ32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology

(2018) Chunxia Qi et al.   Molecular Therapy-Nucleic Acids

Large deletions induced by Cas9 cleavage

(2018) Fatwa Adikusuma et al.   NATURE

Novel Mechanism for Cyclic Dinucleotide Degradation Revealed by Structural Studies of Vibrio Phosphodiesterase V-cGAP3

(2018) Ming-jing Deng et al.   JOURNAL OF MOLECULAR BIOLOGY

Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks

(2018) Yang Yu et al.   NATURE

Base editing: precision chemistry on the genome and transcriptome of living cells

(2018) Holly A. Rees et al.   NATURE REVIEWS GENETICS

Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation

(2017) Jianli Tao et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

(2017) Mara Compagno et al.   NATURE

Mapping the genomic landscape of CRISPR–Cas9 cleavage

(2017) Peter Cameron et al.   NATURE METHODS

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

(2017) Shengdar Q Tsai et al.   NATURE METHODS

Mobile DNA in Health and Disease

(2017) Haig H. Kazazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Somatic L1 Retrotransposition in Human Cancers

(2017) Emma Scott et al.   Viruses-Basel

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

(2017) Alexis C. Komor et al.   Science Advances

Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq

(2016) Daesik Kim et al.   GENOME RESEARCH

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation

(2016) Chunxia Qi et al.   PLoS One

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

(2016) Sabine Klawitter et al.   Nature Communications

Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity

(2015) Ahmet M. Denli et al.   CELL

Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

(2015) Juyi Gao et al.   CELL RESEARCH

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors

(2015) Xiaoling Wang et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair

(2015) Maria E. Morales et al.   PLoS Genetics

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

(2014) Richard L Frock et al.   NATURE BIOTECHNOLOGY

A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency

(2013) Yu Nee Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

LINE-1 Retrotransposition Activity in Human Genomes

(2010) Christine R. Beck et al.   CELL

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE