An engineered prime editor with enhanced editing efficiency in plants

A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver

(2022) Chunwei Zheng et al.   MOLECULAR THERAPY

Genome engineering for crop improvement and future agriculture

(2021) Caixia Gao   CELL

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

(2021) Karl Petri et al.   NATURE BIOTECHNOLOGY

High-efficiency prime editing with optimized, paired pegRNAs in plants

(2021) Qiupeng Lin et al.   NATURE BIOTECHNOLOGY

Genome-wide specificity of prime editors in plants

(2021) Shuai Jin et al.   NATURE BIOTECHNOLOGY

Enhancing prime editing by Csy4-mediated processing of pegRNA

(2021) Yao Liu et al.   CELL RESEARCH

In vivo somatic cell base editing and prime editing

(2021) Gregory A. Newby et al.   MOLECULAR THERAPY

Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

(2021) Myungjae Song et al.   Nature Communications

Efficient and precise generation of Tay–Sachs disease model in rabbit by prime editing system

(2021) Yuqiang Qian et al.   Cell Discovery

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

(2021) Peter J. Chen et al.   CELL

Engineered pegRNAs improve prime editing efficiency

(2021) James W. Nelson et al.   NATURE BIOTECHNOLOGY

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

(2021) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Prime genome editing in rice and wheat

(2020) Qiupeng Lin et al.   NATURE BIOTECHNOLOGY

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

(2020) Michelle F. Richter et al.   NATURE BIOTECHNOLOGY

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

(2020) Russell T. Walton et al.   SCIENCE

Efficient generation of mouse models with the prime editing system

(2020) Yao Liu et al.   Cell Discovery

Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity

(2020) Shuai Jin et al.   MOLECULAR CELL

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Applications of CRISPR–Cas in agriculture and plant biotechnology

(2020) Haocheng Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Precise genome engineering inDrosophilausing prime editing

(2020) Justin A. Bosch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture

(2019) Kunling Chen et al.   Annual Review of Plant Biology

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A

(2018) Yuan Zong et al.   NATURE BIOTECHNOLOGY

Current and future editing reagent delivery systems for plant genome editing

(2017) Yidong Ran et al.   Science China-Life Sciences

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Rapid and Efficient Gene Modification in Rice and Brachypodium Using TALENs

(2013) Qiwei Shan et al.   Molecular Plant

Targeted genome modification of crop plants using a CRISPR-Cas system

(2013) Qiwei Shan et al.   NATURE BIOTECHNOLOGY

Evolution in Action: Plants Resistant to Herbicides

(2010) Stephen B. Powles et al.   Annual Review of Plant Biology

Retroviral reverse transcriptases

(2010) Alon Herschhorn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

When is it time for reverse transcription to start and go?

(2009) Marylène Mougel et al.   Retrovirology