High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Targeted gene silencing in the nervous system with CRISPR-Cas13

(2022) Jackson E. Powell et al.   Science Advances

CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells

(2022) Yuxi Ai et al.   NUCLEIC ACIDS RESEARCH

Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents

(2021) Emmeline L. Blanchard et al.   NATURE BIOTECHNOLOGY

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

(2021) Chunlong Xu et al.   NATURE METHODS

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

(2021) Ahsen Özcan et al.   NATURE

CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

(2020) Changyang Zhou et al.   National Science Review

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Massively multiplexed nucleic acid detection with Cas13

(2020) Cheri M. Ackerman et al.   NATURE

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

(2020) Bingbing He et al.   Protein & Cell

CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

(2020) Gopal Kushawah et al.   DEVELOPMENTAL CELL

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

(2020) Kotaro Kiga et al.   Nature Communications

Programmable RNA Targeting Using CasRx in Flies

(2020) Anna B. Buchman et al.   CRISPR Journal

Base editing: advances and therapeutic opportunities

(2020) Elizabeth M. Porto et al.   NATURE REVIEWS DRUG DISCOVERY

Screening for functional circular RNAs using the CRISPR–Cas13 system

(2020) Siqi Li et al.   NATURE METHODS

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

(2019) Ian M. Slaymaker et al.   Cell Reports

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three New Cs for CRISPR: Collateral, Communicate, Cooperate

(2019) Andrew Varble et al.   TRENDS IN GENETICS

Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

(2019) Bo Zhang et al.   Nature Communications

The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells

(2019) Qixue Wang et al.   Advanced Science

Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems

(2019) Liang-Zhong Yang et al.   MOLECULAR CELL

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

Implementation of the CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing

(2018) Xinyun Jing et al.   NUCLEIC ACIDS RESEARCH

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

(2018) Cheng Zhang et al.   CELL

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

In utero CRISPR-mediated therapeutic editing of metabolic genes

(2018) Avery C. Rossidis et al.   NATURE MEDICINE

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

(2017) Aaron A. Smargon et al.   MOLECULAR CELL

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

(2009) J. C. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels

(2009) D. Steinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH