Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer

Susceptibility of Lung Carcinoma Cells to Nanostructured Lipid Carrier of ARV-825, a BRD4 Degrading Proteolysis Targeting Chimera

(2022) Richa Vartak et al.   PHARMACEUTICAL RESEARCH

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

(2022) Chang Hoon Ji et al.   Nature Communications

Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy

(2022) Jing Gao et al.   Nature Communications

Antibody targeting of E3 ubiquitin ligases for receptor degradation

(2022) Hadir Marei et al.   NATURE

Targeting drugs to tumours using cell membrane-coated nanoparticles

(2022) Ronnie H. Fang et al.   Nature Reviews Clinical Oncology

Versatile Nano‐PROTAC‐Induced Epigenetic Reader Degradation for Efficient Lung Cancer Therapy

(2022) Huan‐Tian Zhang et al.   Advanced Science

Checkpoint Nano‐PROTACs for Activatable Cancer Photo‐Immunotherapy

(2022) Chi Zhang et al.   ADVANCED MATERIALS

Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer

(2022) Jinmei Jin et al.   JCI Insight

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

(2021) Da Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

(2021) Yaxian Zhou et al.   ACS Central Science

Targeted drug delivery strategies for precision medicines

(2021) Mandana T. Manzari et al.   Nature Reviews Materials

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

(2021) Green Ahn et al.   Nature Chemical Biology

Targeted protein degraders crowd into the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Degradation of lipid droplets by chimeric autophagy-tethering compounds

(2021) Yuhua Fu et al.   CELL RESEARCH

Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy

(2021) Jin Yan et al.   CHEMICAL ENGINEERING JOURNAL

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

(2021) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

TF-PROTACs Enable Targeted Degradation of Transcription Factors

(2021) Jing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifunctional small molecules that mediate the degradation of extracellular proteins

(2021) David F. Caianiello et al.   Nature Chemical Biology

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

Smart Nano‐PROTACs Reprogram Tumor Microenvironment for Activatable Photo‐metabolic Cancer Immunotherapy

(2021) Chi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developments of CRBN-based PROTACs as potential therapeutic agents

(2021) Chao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

(2021) Heng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted degradation of anaplastic lymphoma kinase by gold nanoparticle-based multi-headed proteolysis targeting chimeras

(2020) Yingming Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Fundamental aspects of DMPK optimization of targeted protein degraders

(2020) Carina Cantrill et al.   DRUG DISCOVERY TODAY

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

(2020) Sajid Khan et al.   ONCOGENE

Nanoformulation of PROteolysis TArgeting Chimera targeting ‘undruggable’ c-Myc for the treatment of pancreatic cancer

(2020) Aishwarya Saraswat et al.   Nanomedicine

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

(2020) Tao Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PROTAC-DB: an online database of PROTACs

(2020) Gaoqi Weng et al.   NUCLEIC ACIDS RESEARCH

Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer

(2020) Francisco J. Cimas et al.   Pharmaceutics

RNA‐PROTACs: Degraders of RNA‐Binding Proteins

(2020) Alice Ghidini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-molecule-induced polymerization triggers degradation of BCL6

(2020) Mikołaj Słabicki et al.   NATURE

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

N-degron and C-degron pathways of protein degradation

(2019) Alexander Varshavsky   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Nanocarriers for Intracellular Protein Delivery

(2019) Xiaofei Qin et al.   ADVANCED MATERIALS

BRD4 PROTAC as a novel therapeutic approach for the treatment of vemurafenib resistant melanoma: Preformulation studies, formulation development and in vitro evaluation

(2019) Drishti Rathod et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Smart cancer nanomedicine

(2019) Roy van der Meel et al.   Nature Nanotechnology

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer

(2018) Priyanka Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

(2018) Vittoria Zoppi et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

(2018) Huanbin Wang et al.   Nature Chemical Biology

Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure

(2018) Tao Fang et al.   NATURE METHODS

PLGA-Based Nanoparticles in Cancer Treatment

(2018) Sima Rezvantalab et al.   Frontiers in Pharmacology

Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern

(2017) Pik-Ling Lam et al.   Nanomedicine

Expanding and reprogramming the genetic code

(2017) Jason W. Chin   NATURE

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

(2017) Ting Han et al.   SCIENCE

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

(2017) Hyunjoo Cha-Molstad et al.   Nature Communications

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

(2016) Mary E. Matyskiela et al.   NATURE

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug

(2016) Kai Zhao et al.   Current Drug Delivery

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

(2015) Michael Zengerle et al.   ACS Chemical Biology

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance

(2015) Lang Rao et al.   Small

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

(2014) Xuelai Fan et al.   NATURE NEUROSCIENCE

Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria

(2013) Chiaki Ito et al.   MOLECULAR CELL

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

(2012) A Lopez-Girona et al.   LEUKEMIA

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles

(2011) Marites P. Melancon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bio-inspired, bioengineered and biomimetic drug delivery carriers

(2011) Jin-Wook Yoo et al.   NATURE REVIEWS DRUG DISCOVERY

Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation

(2010) Kedra Cyrus  et al.   CHEMBIOCHEM

Gold nanostructures: a class of multifunctional materials for biomedical applications

(2010) Claire M. Cobley et al.   CHEMICAL SOCIETY REVIEWS

Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

(2010) Yukihiro Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

(2008) Ashley R. Schneekloth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS