N-degron and C-degron pathways of protein degradation

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases

(2018) Hsiu-Chuan Lin et al.   MOLECULAR CELL

Reduction in adaptor amounts establishes degradation hierarchy among protease substrates

(2018) Jinki Yeom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

(2018) Young Dong Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway

(2018) Jeong-Mok Kim et al.   SCIENCE

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation at the crossroads of development and disease

(2017) Michael Rape   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway

(2017) Jang-Hyun Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

(2017) Mark D. White et al.   Nature Communications

A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

(2017) Zhaowei Wang et al.   eLife

Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

(2016) Min Kyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

(2016) Henriette Aksnes et al.   TRENDS IN BIOCHEMICAL SCIENCES

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

(2016) Daniela Justa-Schuch et al.   eLife

Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

(2015) Vinayak Vittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer

(2015) R. F. Shearer et al.   MOLECULAR CANCER RESEARCH

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation

(2015) Daniela Gödderz et al.   Scientific Reports

Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates

(2014) Izarys Rivera-Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway

(2014) Konstantin I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway

(2013) Christopher S. Brower et al.   MOLECULAR CELL

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

The type-2 N-end rule peptide recognition activity of Ubr11 ubiquitin ligase is required for the expression of peptide transporters

(2012) Kenji Kitamura et al.   FEBS LETTERS

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

(2012) Konstantin I. Piatkov et al.   MOLECULAR CELL

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

(2012) K. I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+proteases

(2011) D.A. Dougan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Defining the geometry of the two-component proteasome degron

(2011) Tomonao Inobe et al.   Nature Chemical Biology

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway

(2009) Haiqing Wang et al.   MOLECULAR CELL

ClpS is the recognition component forEscherichia colisubstrates of the N-end rule degradation pathway

(2009) Ronny Schmidt et al.   MOLECULAR MICROBIOLOGY

Discovery of Cellular Regulation by Protein Degradation

(2008) Alexander Varshavsky   JOURNAL OF BIOLOGICAL CHEMISTRY