Small-molecule-induced polymerization triggers degradation of BCL6

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis

(2020) Stefanie Schlager et al.   Oncotarget

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

(2020) Benjamin R. Bellenie et al.   JOURNAL OF MEDICINAL CHEMISTRY

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

(2020) Mikołaj Słabicki et al.   NATURE

Patterns of substrate affinity, competition and degradation kinetics underlie biological activity of thalidomide analogs

(2019) Adam S. Sperling et al.   BLOOD

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

(2019) Tyler B. Faust et al.   Nature Chemical Biology

Efficient flexible backbone protein–protein docking for challenging targets

(2018) Nicholas A Marze et al.   BIOINFORMATICS

Plasticity in binding confers selectivity in ligand-induced protein degradation

(2018) Radosław P. Nowak et al.   Nature Chemical Biology

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity

(2018) Quinlan L. Sievers et al.   BLOOD

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

(2018) Katherine A Donovan et al.   eLife

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

(2018) Quinlan L. Sievers et al.   SCIENCE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

(2017) Lei Ji et al.   GENES & DEVELOPMENT

Proteins evolve on the edge of supramolecular self-assembly

(2017) Hector Garcia-Seisdedos et al.   NATURE

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

(2017) Nina Kerres et al.   Cell Reports

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

(2016) Mariano G. Cardenas et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis

(2014) Katerina Hatzi et al.   TRENDS IN MOLECULAR MEDICINE

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

(2010) Leandro C. Cerchietti et al.   CANCER CELL

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies

(2008) Wassim Abdulrahman et al.   ANALYTICAL BIOCHEMISTRY

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

(2008) Stella M. Ranuncolo et al.   BLOOD CELLS MOLECULES AND DISEASES

HELFIT: Helix fitting by a total least squares method

(2008) Purevjav Enkhbayar et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

(2008) Alexandru F. Ghetu et al.   MOLECULAR CELL