Smart Nano‐PROTACs Reprogram Tumor Microenvironment for Activatable Photo‐metabolic Cancer Immunotherapy

A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

(2021) Cheng Xu et al.   ADVANCED MATERIALS

Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

(2021) Yuyan Jiang et al.   Nature Communications

Intracellular Bottom‐up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX‐2 Inactivation

(2021) Liandong Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

(2021) Cheng Xu et al.   ADVANCED MATERIALS

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Charge‐Reversal Polymer Nano‐modulators for Photodynamic Immunotherapy of Cancer

(2021) Shasha He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling

(2021) Amy Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

(2021) Jieli Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

(2021) Jing Liu et al.   ADVANCED MATERIALS

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy

(2020) Zecong Xiao et al.   Science Advances

Photoactivatable Protherapeutic Nanomedicine for Cancer

(2020) Yan Zhang et al.   ADVANCED MATERIALS

Challenges and Opportunities in Cancer Drug Resistance

(2020) Richard A. Ward et al.   CHEMICAL REVIEWS

Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs

(2020) Michael J. Bond et al.   ACS Central Science

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

(2020) Hongzhang Deng et al.   Nature Communications

Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

(2020) Jingchao Li et al.   ADVANCED MATERIALS

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

(2020) Ziling Zeng et al.   ADVANCED MATERIALS

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

(2019) Filipe Martins et al.   Nature Reviews Clinical Oncology

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Organic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy

(2019) Jingchao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting metabolism to regulate immune responses in autoimmunity and cancer

(2019) Chirag H. Patel et al.   NATURE REVIEWS DRUG DISCOVERY

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Combretastatin A4 Nanoparticles Combined with Hypoxia-Sensitive Imiquimod: A New Paradigm for the Modulation of Host Immunological Responses during Cancer Treatment

(2019) Na Shen et al.   NANO LETTERS

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

A Transformable Chimeric Peptide for Cell Encapsulation to Overcome Multidrug Resistance

(2018) Chi Zhang et al.   Small

Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)

(2018) Chung Hyo Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

SCF ubiquitin ligase-targeted therapies

(2014) Jeffrey R. Skaar et al.   NATURE REVIEWS DRUG DISCOVERY

Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs

(2013) J. Hines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA