Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer

Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

(2022) Fazhi Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas

(2021) Tenny Mudianto et al.   CLINICAL CANCER RESEARCH

AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner

(2021) Shailendra Shah et al.   Frontiers in Cell and Developmental Biology

Co-delivery of paclitaxel and STAT3 siRNA by a multifunctional nanocomplex for targeted treatment of metastatic breast cancer

(2021) Kaipei Luo et al.   Acta Biomaterialia

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway

(2021) Ge Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Mechanisms involved in the anti-tumor effects of Toosendanin in glioma cells

(2021) Chaochao Zhang et al.   Cancer Cell International

Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma

(2021) Seok-Young Kim et al.   CLINICAL CANCER RESEARCH

Epithelial Regeneration Ability of Crohn’s Disease Assessed Using Patient-Derived Intestinal Organoids

(2021) Chansu Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer

(2021) Giulia Rizzo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TF-PROTACs Enable Targeted Degradation of Transcription Factors

(2021) Jing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Signal transducer and activator of transcription 3 signaling in tumor immune evasion

(2021) Luying Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma

(2021) Tianfeng Yang et al.   PHYTOTHERAPY RESEARCH

Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy

(2021) Jingnan Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma

(2021) Ana Paula Morelli et al.   NEOPLASIA

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

(2020) Ka Yang et al.   ACS Medicinal Chemistry Letters

Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis

(2020) Huihui Wang et al.   BIOCHEMICAL PHARMACOLOGY

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

(2020) Yonghan He et al.   Journal of Hematology & Oncology

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry

(2020) Wen-Hao Guo et al.   Nature Communications

SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival

(2020) Guoxiang Fu et al.   CANCER LETTERS

Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

(2019) Mingjing Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Right Cu 2− x S@MnS Core–Shell Nanoparticles as a Photo/H 2 O 2 ‐Responsive Platform for Effective Cancer Theranostics

(2019) Xiaojuan Huang et al.   Advanced Science

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

(2019) Haibin Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner

(2018) Shanshan Sun et al.   CLINICAL CANCER RESEARCH

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

(2018) Jinlei Bian et al.   BIOORGANIC CHEMISTRY

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

(2018) Loukik Arora et al.   Cancers

Dynamic Imaging of Small Molecule Induced Protein–Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach

(2018) Chan-I Chung et al.   ANALYTICAL CHEMISTRY

Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma

(2018) Christina Karamboulas et al.   Cell Reports

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3

(2017) T Zhang et al.   ONCOGENE

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

(2016) Jessica L. Geiger et al.   ORAL ONCOLOGY

Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer

(2015) Shrikant Balasaheb Mali   ORAL ONCOLOGY

Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas

(2014) S. Sun et al.   CANCER RESEARCH

Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

(2014) Maupali Dasgupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Stat3 Orchestrates Tumor Development and Progression: The Achilles Heel of Head and Neck Cancers?

(2010) M. Masuda et al.   CURRENT CANCER DRUG TARGETS

Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma

(2009) S Takemoto et al.   BRITISH JOURNAL OF CANCER

Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell Carcinoma

(2008) C. Chen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Roles of unphosphorylated STATs in signaling

(2008) Jinbo Yang et al.   CELL RESEARCH

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

(2008) Chun-Liang Chen et al.   Molecular Cancer

Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer

(2008) Jan B. Vermorken et al.   NEW ENGLAND JOURNAL OF MEDICINE