Chemistry of Lipid Nanoparticles for RNA Delivery

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

Self-assembled mRNA vaccines

(2021) Jeonghwan Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Cationic lipids for gene delivery: many players, one goal

(2021) Federica Ponti et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

(2021) M. Kim et al.   Science Advances

Cytosolic Delivery of Nucleic Acids: The case of Ionizable Lipid Nanoparticles

(2021) Michele Schlich et al.   Bioengineering & Translational Medicine

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

(2021) Federica Sebastiani et al.   ACS Nano

Encapsulation state of messenger RNA inside lipid nanoparticles

(2021) Mark L. Brader et al.   BIOPHYSICAL JOURNAL

Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles

(2021) Yuchen Fan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

(2021) Kimberly J. Hassett et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer

(2021) Manu Smriti Singh et al.   Small

Acidic pH-induced changes in lipid nanoparticle membrane packing

(2021) Kyoka Koitabashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipids and Lipid Derivatives for RNA Delivery

(2021) Yuebao Zhang et al.   CHEMICAL REVIEWS

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

(2021) Manuel J. Carrasco et al.   Communications Biology

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

(2020) Jeonghwan Kim et al.   Cellular and Molecular Bioengineering

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Long-term storage of lipid-like nanoparticles for mRNA delivery

(2020) Pengxuan Zhao et al.   Bioactive Materials

PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

(2020) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bilayer-Coated Nanoparticles Reveal How Influenza Viral Entry Depends on Membrane Deformability but Not Curvature

(2020) Ana M. Villamil Giraldo et al.   Journal of Physical Chemistry Letters

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

Life in the lumen: The multivesicular endosome

(2019) Jean Gruenberg   TRAFFIC

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Cubosomes; the next generation of smart lipid nanoparticles?

(2018) Hanna Maria Gabriella Barriga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration

(2018) Hiroki Tanaka et al.   MOLECULAR PHARMACEUTICS

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

(2018) Hamideh Parhiz et al.   JOURNAL OF CONTROLLED RELEASE

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

(2017) Yasmin Granot et al.   SEMINARS IN IMMUNOLOGY

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

(2016) Justin B Lee et al.   Molecular Therapy-Nucleic Acids

Cuboplexes: Topologically Active siRNA Delivery

(2015) Hojun Kim et al.   ACS Nano

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

(2015) Alex K. K. Leung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

(2014) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery

(2014) Marian E. Gindy et al.   LANGMUIR

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

(2014) Varun Kumar et al.   Molecular Therapy-Nucleic Acids

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

(2013) Charles H. Jones et al.   MOLECULAR PHARMACEUTICS

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Lipid-mediated DNA and siRNA transfection efficiency depends on peptide headgroup

(2013) Xiao-Xiang Zhang et al.   Soft Matter

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKaon Cationic Lipid−Biomembrane Interactions

(2011) Jingtao Zhang et al.   LANGMUIR

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Physical approaches to biomaterial design

(2008) Samir Mitragotri et al.   NATURE MATERIALS