Bifunctional small molecules that mediate the degradation of extracellular proteins

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

(2021) Yaxian Zhou et al.   ACS Central Science

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

A Review of PCSK9 Inhibitors and their effects on cardiovascular disease

(2019) Bo Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

(2019) Joshua B. Bilsborrow et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

(2018) Jonathan Martínez-Fábregas et al.   Nature Communications

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

(2017) Michael Tanowitz et al.   NUCLEIC ACIDS RESEARCH

Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection

(2017) Lisa D. Cervia et al.   PLoS One

Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor

(2016) Xiangang Huang et al.   BIOCONJUGATE CHEMISTRY

A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors

(2016) José A. Cisneros et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Selectivity of commonly used inhibitors of clathrin-mediated and caveolae-dependent endocytosis of G protein–coupled receptors

(2015) Shuohan Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation

(2015) Cláudia L Fernandes et al.   GLYCOBIOLOGY

Asialoglycoprotein receptor mediated hepatocyte targeting — Strategies and applications

(2015) Anisha A. D'Souza et al.   JOURNAL OF CONTROLLED RELEASE

Design, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor

(2015) Pawel Dziedzic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

An intrinsic mechanism of secreted protein aging and turnover

(2015) Won Ho Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Mannose and Asialoglycoprotein Receptor Expression Determines Glycoprotein Hormone Half-life at Critical Points in the Reproductive Cycle

(2014) Yiling Mi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

(2014) Renata Grozovsky et al.   NATURE MEDICINE

Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

(2013) Bin Shi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes

(2012) Takuo Onizuka et al.   FEBS Journal

Glycomimetic Ligands for the Human Asialoglycoprotein Receptor

(2012) Sreeman K. Mamidyala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1

(2012) Qian Ba et al.   PLoS One

Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor

(2011) Clifford S. Guy et al.   HEPATOLOGY

Hepatocyte entry leads to degradation of autoreactive CD8 T cells

(2011) V. Benseler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte Targeting and Intracellular Copper Chelation by a Thiol-Containing Glycocyclopeptide

(2010) Anaïs M. Pujol et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

The Asialoglycoprotein Receptor Regulates Levels of Plasma Glycoproteins Terminating with Sialic Acid α2,6-Galactose

(2008) Lindsay M. Steirer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY