The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Degradation of lipid droplets by chimeric autophagy-tethering compounds

(2021) Yuhua Fu et al.   CELL RESEARCH

Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy

(2020) Seulgi Shin et al.   PROGRESS IN NEUROBIOLOGY

Desminopathy: Novel Desmin Variants, a New Cardiac Phenotype, and Further Evidence for Secondary Mitochondrial Dysfunction

(2020) Miloš Kubánek et al.   Journal of Clinical Medicine

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

(2019) Jiantao Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-degron and C-degron pathways of protein degradation

(2019) Alexander Varshavsky   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors

(2019) Timo Heinrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

(2019) M Catarina Silva et al.   eLife

Advances in targeted degradation of endogenous proteins

(2019) Sascha Röth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The N-Degron Pathway Mediates ER-phagy

(2019) Chang Hoon Ji et al.   MOLECULAR CELL

Tau binding protein CAPON induces tau aggregation and neurodegeneration

(2019) Shoko Hashimoto et al.   Nature Communications

RNA editing in the forefront of epitranscriptomics and human health

(2019) Theodoulakis Christofi et al.   Journal of Translational Medicine

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

(2019) Nobumichi Ohoka et al.   ACS Chemical Biology

Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers

(2019) Paulin L. Salomon et al.   MOLECULAR PHARMACEUTICS

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro

(2018) Waleed Al-Khyatt et al.   BMC CANCER

Targeted protein degradation and the enzymology of degraders

(2018) Stewart L Fisher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies.

(2018) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network

(2018) Jie Ding et al.   ONCOGENE

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

(2018) Young Dong Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer

(2018) Kush Dalal et al.   CANCER LETTERS

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

(2018) Antonio Heras-Garvin et al.   MOVEMENT DISORDERS

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

(2017) Hyunjoo Cha-Molstad et al.   Nature Communications

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

(2016) C Zhao et al.   ONCOGENE

Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR

(2015) Michael Boettcher et al.   MOLECULAR CELL

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Computational Approach to Evaluate the Androgenic Affinity of Iprodione, Procymidone, Vinclozolin and Their Metabolites

(2014) Corrado Lodovico Galli et al.   PLoS One

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY