Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

(2022) Zhao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptidomimetics: An Overview of Recent Medicinal Chemistry Efforts toward the Discovery of Novel Small Molecule Inhibitors

(2022) Giovanna Li Petri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale

(2022) Michael A. McCoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein–Protein Interaction

(2022) Zhen Wang et al.   ACS Medicinal Chemistry Letters

A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

(2022) Helen Tanton et al.   Science Advances

Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study

(2022) Kiminori Kimura et al.   EBioMedicine

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

(2022) Xuexuan Wu et al.   Antioxidants

Direct targeting of β ‐catenin in the Wnt signaling pathway: Current progress and perspectives

(2021) Zhen Wang et al.   MEDICINAL RESEARCH REVIEWS

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

(2021) Mathias Wendt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in β-catenin/BCL9 protein–protein interaction inhibitors

(2021) Hao Zhang et al.   Future Medicinal Chemistry

Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer

(2021) Zhiqing Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2021) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

(2021) Karmani Shah et al.   PHARMACOLOGICAL RESEARCH

Advances in targeting the WNT/β-catenin signaling pathway in cancer

(2021) Avradip Chatterjee et al.   DRUG DISCOVERY TODAY

Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2021) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

(2021) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2021) Zilu Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis

(2021) Vida Vafaizadeh et al.   ONCOGENE

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling

(2021) Wei Tu et al.   Cell Death & Disease

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Application of Negative Design To Design a More Desirable Virtual Screening Library

(2020) Zi-Yi Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutations in genes connected with the TCF7L2 transcription factor are associated with a poor prognosis in non-small cell lung cancer

(2020) Shawn J. Rice et al.   LUNG CANCER

Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies

(2020) Mauricio A. Medina et al.   International Journal of Environmental Research and Public Health

Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease

(2020) Juan Rafael Muñoz-Castañeda et al.   Toxins

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

(2020) Cody J. Aros et al.   Cell Stem Cell

Discovery and Optimization of Benzenesulfonamide-based HBV Capsid Modulators via Contemporary Medicinal Chemistry Strategies

(2020) Yujie Ren et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wnt/β-Catenin Signaling in Oral Carcinogenesis

(2020) Montserrat Reyes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

(2020) Hongwei Liao et al.   Cell Discovery

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

(2020) Je-Hwan Lee et al.   Blood Advances

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

(2020) Dirk Kessler et al.   ChemMedChem

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

(2019) Kyle R. Simonetta et al.   Nature Communications

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

(2019) David M. Gay et al.   Nature Communications

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models

(2019) Juliusz Mieszczanek et al.   Nature Communications

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

(2019) Jerry Harb et al.   Current Oncology Reports

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options

(2019) Harmen van Andel et al.   LEUKEMIA

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

(2019) Peng Sang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells

(2019) M. Feng et al.   Science Advances

The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway

(2019) Sahyun Pak et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Low BCL9 expression inhibited ovarian epithelial malignant tumor progression by decreasing proliferation, migration, and increasing apoptosis to cancer cells

(2019) Jing Wang et al.   Cancer Cell International

Targeted disruption of the BCL9/β-catenin interaction by endosomal-escapable nanoparticles functionalized with an E-cadherin-derived peptide

(2019) Guang Yang et al.   NANOTECHNOLOGY

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

(2019) Sonal Patel et al.   Frontiers in Immunology

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Where Do Recent Small Molecule Clinical Development Candidates Come From?

(2018) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2018) Min Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents

(2018) Antonella Borrelli et al.   MOLECULES

Plasticity in binding confers selectivity in ligand-induced protein degradation

(2018) Radosław P. Nowak et al.   Nature Chemical Biology

Is β-Catenin a Druggable Target for Cancer Therapy?

(2018) Can Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Abstract 3764: Porcupine inhibitor RXC004 enhances immune response in pre-clinical models of cancer

(2018) Inder Bhamra et al.   CANCER RESEARCH

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage

(2018) Masaya Ono et al.   PLoS One

WNT Signaling in Cancer Immunosurveillance

(2018) Lorenzo Galluzzi et al.   TRENDS IN CELL BIOLOGY

TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

(2018) Nikolaos Doumpas et al.   EMBO JOURNAL

Wnt–β-catenin signalling in liver development, health and disease

(2018) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities

(2018) Piao Huang et al.   PHARMACOLOGY & THERAPEUTICS

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

(2018) Jeffrey A. Schneider et al.   Nature Communications

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

(2018) Xiaofei Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Screening-based approaches to identify small molecules that inhibit protein–protein interactions

(2017) Sehee Choi et al.   Expert Opinion on Drug Discovery

Small molecules inhibiting Keap1–Nrf2 protein–protein interactions: a novel approach to activate Nrf2 function

(2017) Chunlin Zhuang et al.   MedChemComm

Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma

(2017) Wei Xu et al.   Scientific Reports

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

(2017) Kiminori Kimura et al.   EBioMedicine

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo

(2017) Seung Ho Shin et al.   EBioMedicine

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation

(2016) Paul D. Thomas et al.   CELL BIOLOGY AND TOXICOLOGY

γ-AApeptides as a New Class of Peptidomimetics

(2016) Peng Teng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current Experimental Methods for Characterizing Protein-Protein Interactions

(2016) Mi Zhou et al.   ChemMedChem

The Wnt signaling pathway in cancer

(2016) Yann Duchartre et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

(2016) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in Scaffold Hopping

(2016) Ye Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease

(2016) Victor L. Perez et al.   Ocular Surface

Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction

(2016) Qinghao Zhang et al.   PLoS One

Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Inhibitors

(2016) John A. Wisniewski et al.   ACS Medicinal Chemistry Letters

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

(2016) So-Young Hwang et al.   Cell Reports

TCF/LEF Transcription Factors: An Update from the Internet Resources

(2016) Dusan Hrckulak et al.   Cancers

Specific Direct Small Molecule p300/β-Catenin Antagonists Maintain Stem Cell Potency

(2016) Yusuke Higuchi et al.   Current Molecular Pharmacology

AlphaScreen selectivity assay for β-catenin/B-cell lymphoma 9 inhibitors

(2015) Min Zhang et al.   ANALYTICAL BIOCHEMISTRY

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

A Small-Molecule Antagonist of the  -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

(2015) L. Fang et al.   CANCER RESEARCH

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

(2015) Chunquan Sheng et al.   CHEMICAL SOCIETY REVIEWS

Development of Small Molecules Targeting the Wnt Signaling Pathway in Cancer Stem Cells for the Treatment of Colorectal Cancer

(2015) Lele Song et al.   Clinical Colorectal Cancer

Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety

(2015) J. Leon Catrow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions

(2015) Logan R. Hoggard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Tumors induce immune tolerance through activation of β-catenin/TCF4 signaling in dendritic cells: A novel therapeutic target for cancer immunotherapy

(2015) Amol Suryawanshi et al.   OncoImmunology

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

(2015) Yosuke Osawa et al.   EBioMedicine

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

(2014) Wenxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Small Molecule Modulators of Protein–Protein Interactions: Selected Case Studies

(2014) Madhu Aeluri et al.   CHEMICAL REVIEWS

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

(2014) Melanie Eichenmüller et al.   JOURNAL OF HEPATOLOGY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

(2014) Priscilla K Brastianos et al.   NATURE GENETICS

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Zheng Huang et al.   ACS Chemical Biology

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

(2013) Gernot Hahne et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bridging the past and the future of virology: Surface plasmon resonance as a powerful tool to investigate virus/host interactions

(2013) Marco Rusnati et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Molecular determinants of drug–receptor binding kinetics

(2013) Albert C. Pan et al.   DRUG DISCOVERY TODAY

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

(2013) Francisco X. Talamas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells

(2013) Xingyao Li et al.   PLoS One

Inhibition of androgen receptor and  -catenin activity in prostate cancer

(2013) E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Min Zhang et al.   ACS Medicinal Chemistry Letters

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement

(2012) Binxun Yu et al.   ACS Chemical Biology

A pull-down method with a biotinylated bait protein prepared by cell-free translation using a puromycin linker

(2012) Yuki Mochizuki et al.   ANALYTICAL BIOCHEMISTRY

Immuno-oncology: understanding the function and dysfunction of the immune system in cancer

(2012) O. J. Finn   ANNALS OF ONCOLOGY

Inhibition of Wnt1 expression reduces the enrichment of cancer stem cells in a mouse model of breast cancer

(2012) A-Ram Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway

(2012) Hui-Jye Chen et al.   BIOCHEMICAL PHARMACOLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/ -Catenin Signaling in Human Melanoma Cells

(2012) T. Yaguchi et al.   JOURNAL OF IMMUNOLOGY

CTNNB1 mutation analysis is a useful tool for the diagnosis of desmoid tumors: a study of 260 desmoid tumors and 191 potential morphologic mimics

(2012) Sophie Le Guellec et al.   MODERN PATHOLOGY

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

(2012) David Koes et al.   PLoS One

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Celebrating 30 Years of Wnt Signaling

(2012) F. Verkaar et al.   Science Signaling

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

(2012) Marc de la Roche et al.   Nature Communications

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways

(2011) N. Shukla et al.   CLINICAL CANCER RESEARCH

The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells

(2011) Y.-M. Kim et al.   CURRENT CANCER DRUG TARGETS

The Wnt signaling pathways and cell adhesion

(2011) Nancy Amin   Frontiers in Bioscience-Landmark

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Structural basis of coactivation of liver receptor homolog-1 by  -catenin

(2011) F. Yumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas

(2010) J. Deka et al.   CANCER RESEARCH

Fluorescence polarization assays in small molecule screening

(2010) Wendy A Lea et al.   Expert Opinion on Drug Discovery

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1

(2010) Jinglucy Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Analysis of the Interaction of BCL9 with β-Catenin and Development of Fluorescence Polarization and Surface Plasmon Resonance Binding Assays for this Interaction

(2009) Steven A. Kawamoto et al.   BIOCHEMISTRY

Recent trends and some applications of isothermal titration calorimetry in biotechnology

(2009) L. Selva Roselin et al.   Biotechnology Journal

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Rhodanine as a Privileged Scaffold in Drug Discovery

(2009) T. Tomasic et al.   CURRENT MEDICINAL CHEMISTRY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

β-Hairpin Peptidomimetics: Design, Structures and Biological Activities

(2008) John A. Robinson   ACCOUNTS OF CHEMICAL RESEARCH

The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells

(2008) Marc de la Roche et al.   BMC CANCER

A genome-wide RNAi screen for Wnt/ -catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

(2008) W. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE

Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans

(2007) André Ziegler   ADVANCED DRUG DELIVERY REVIEWS

Tankyrase function at telomeres, spindle poles, and beyond

(2007) Susan J. Hsiao et al.   BIOCHIMIE