Direct targeting of β ‐catenin in the Wnt signaling pathway: Current progress and perspectives
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Direct targeting of
β
‐catenin in the Wnt signaling pathway: Current progress and perspectives
Authors
Keywords
-
Journal
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-01-22
DOI
10.1002/med.21787
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery of chemical probes that suppress Wnt/β‐catenin signaling through high‐throughput screening
- (2020) Kiyoshi Yamaguchi et al. CANCER SCIENCE
- Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer
- (2020) Fumiyuki Shirai et al. JOURNAL OF MEDICINAL CHEMISTRY
- A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
- (2020) Hongwei Liao et al. Cell Discovery
- Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome
- (2020) Je-Hwan Lee et al. Blood Advances
- Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
- (2020) Jo Waaler et al. Communications Biology
- WNT/β-catenin pathway activation correlates with immune exclusion across human cancers
- (2019) Jason J. Luke et al. CLINICAL CANCER RESEARCH
- Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction
- (2019) Zhen Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors
- (2019) Peng Sang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
- (2019) M. Feng et al. Science Advances
- β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma
- (2019) Marina Ruiz de Galarreta et al. Cancer Discovery
- Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity
- (2019) Hans-Peter Buchstaller et al. JOURNAL OF MEDICINAL CHEMISTRY
- Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance
- (2019) Teeuwssen et al. Journal of Clinical Medicine
- The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α
- (2019) Chen Shen et al. BIOCHEMISTRY
- Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer
- (2018) Andrii Monastyrskyi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction
- (2018) Min Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cryo-EM in drug discovery: achievements, limitations and prospects
- (2018) Jean-Paul Renaud et al. NATURE REVIEWS DRUG DISCOVERY
- Genetic Mechanisms of Immune Evasion in Colorectal Cancer
- (2018) Catherine S. Grasso et al. Cancer Discovery
- A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma
- (2018) Jezabel Rodriguez-Blanco et al. CLINICAL CANCER RESEARCH
- Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
- (2018) Jeffrey A. Schneider et al. Nature Communications
- The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination
- (2018) Christopher G. Jones et al. ACS Central Science
- Waste disposal—An attractive strategy for cancer therapy
- (2017) Jemilat Salami et al. SCIENCE
- Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial
- (2017) Kiminori Kimura et al. EBioMedicine
- A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo
- (2017) Seung Ho Shin et al. EBioMedicine
- Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Inhibitors
- (2016) John A. Wisniewski et al. ACS Medicinal Chemistry Letters
- β-Catenin C-terminal signals suppress p53 and are essential for artery formation
- (2016) Dario F. Riascos-Bernal et al. Nature Communications
- Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
- (2016) So-Young Hwang et al. Cell Reports
- Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells
- (2015) G.-B. Jang et al. CANCER RESEARCH
- A Small-Molecule Antagonist of the -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
- (2015) L. Fang et al. CANCER RESEARCH
- Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
- (2015) Lukas E. Dow et al. CELL
- Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety
- (2015) J. Leon Catrow et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pan Assay Interference Compounds (PAINS) and Other Promiscuous Compounds in Antifungal Research
- (2015) Martin Pouliot et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions
- (2015) Logan R. Hoggard et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
- (2015) Stefani Spranger et al. NATURE
- Hot spot-based design of small-molecule inhibitors for protein–protein interactions
- (2014) Wenxing Guo et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?
- (2014) Tomasz Cierpicki et al. IMMUNOLOGICAL REVIEWS
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- Can we safely target the WNT pathway?
- (2014) Michael Kahn NATURE REVIEWS DRUG DISCOVERY
- Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions
- (2013) Zheng Huang et al. ACS Chemical Biology
- Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling
- (2013) Hong-Kui Cui et al. CELL RESEARCH
- Wnt Signaling Pathway in Non-Small Cell Lung Cancer
- (2013) D. J. Stewart JNCI-Journal of the National Cancer Institute
- Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo
- (2013) Henryk Dudek et al. MOLECULAR THERAPY
- Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells
- (2013) Xingyao Li et al. PLoS One
- Inhibition of androgen receptor and -catenin activity in prostate cancer
- (2013) E. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement
- (2012) Binxun Yu et al. ACS Chemical Biology
- Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer
- (2012) Ze-Guang Han Annual Review of Genomics and Human Genetics
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Inhibition of oncogenic Wnt signaling through direct targeting of -catenin
- (2012) T. N. Grossmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling
- (2012) K. Takada et al. Science Translational Medicine
- WNT secretion and signalling in human disease
- (2012) Patrick Herr et al. TRENDS IN MOLECULAR MEDICINE
- Wnt Signaling in Cancer
- (2012) P. Polakis Cold Spring Harbor Perspectives in Biology
- An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
- (2012) Marc de la Roche et al. Nature Communications
- Role of the Wnt Pathway in Thyroid Cancer
- (2012) Ana Sastre-Perona et al. Frontiers in Endocrinology
- Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction
- (2011) Wang Tian et al. BIOCHEMISTRY
- Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
- (2011) J. Waaler et al. CANCER RESEARCH
- Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation
- (2011) Jungsug Gwak et al. CELL RESEARCH
- The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells
- (2011) Y.-M. Kim et al. CURRENT CANCER DRUG TARGETS
- Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
- (2011) Steven A. Kawamoto et al. JOURNAL OF MEDICINAL CHEMISTRY
- IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation
- (2011) J K Cheong et al. ONCOGENE
- Structural basis of coactivation of liver receptor homolog-1 by -catenin
- (2011) F. Yumoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
- (2011) F. C. Gonsalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1
- (2010) Jinglucy Sun et al. JOURNAL OF MOLECULAR BIOLOGY
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- (2010) Curtis A Thorne et al. Nature Chemical Biology
- Analysis of the Interaction of BCL9 with β-Catenin and Development of Fluorescence Polarization and Surface Plasmon Resonance Binding Assays for this Interaction
- (2009) Steven A. Kawamoto et al. BIOCHEMISTRY
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- β-Catenin hits chromatin: regulation of Wnt target gene activation
- (2009) Christian Mosimann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling
- (2009) J. Heuberger et al. Cold Spring Harbor Perspectives in Biology
- The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells
- (2008) Marc de la Roche et al. BMC CANCER
- Crystal Structure of a Full-Length β-Catenin
- (2008) Yi Xing et al. STRUCTURE
- Tankyrase function at telomeres, spindle poles, and beyond
- (2007) Susan J. Hsiao et al. BIOCHIMIE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More