Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

(2020) W. Seth Horne et al.   Nature Chemistry

Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

(2020) Andrew M. White et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting the β-catenin signaling for cancer therapy

(2020) Xue Zhang et al.   PHARMACOLOGICAL RESEARCH

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrocyclic Control in Helix Mimetics

(2019) Danielle A. Guarracino et al.   CHEMICAL REVIEWS

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

(2019) Philipp M. Cromm et al.   CHEMBIOCHEM

Peptides and peptidomimetics as inhibitors of protein–protein interactions involving β-sheet secondary structures

(2019) José Laxio Arenas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Designing macrocyclic disulfide-rich peptides for biotechnological applications

(2018) Conan K. Wang et al.   Nature Chemical Biology

Is β-Catenin a Druggable Target for Cancer Therapy?

(2018) Can Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme

(2018) Dan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

(2018) Jeffrey A. Schneider et al.   Nature Communications

Phage Selection of Chemically Stabilized α-Helical Peptide Ligands

(2016) Philippe Diderich et al.   ACS Chemical Biology

Stapling peptides using cysteine crosslinking

(2016) David P Fairlie et al.   BIOPOLYMERS

A Thioether-Stabilizedd-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicansAbility

(2016) Bingchuan Zhao et al.   CHEMBIOCHEM

1,2,3-Triazole Bridge as Conformational Constrain in β-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions

(2016) V. Celentano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling

(2016) Tsung-Hua Hsieh et al.   Scientific Reports

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disulfide-Mediated β-Strand Dimers: Hyperstable β-Sheets Lacking Tertiary Interactions and Turns

(2015) Brandon L. Kier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics

(2015) Laura E. Hanold et al.   PLoS One

Anatomy of β-Strands at Protein–Protein Interfaces

(2014) Andrew M. Watkins et al.   ACS Chemical Biology

Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation

(2014) Hannah Lingard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulators of Protein–Protein Interactions

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Design and Applications of Protein Epitope Mimetics

(2014) John A. Robinson   CHIMIA

Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Zheng Huang et al.   ACS Chemical Biology

Diaminodiacid-Based Solid-Phase Synthesis of Peptide Disulfide Bond Mimics

(2013) Hong-Kui Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

(2013) Gernot Hahne et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement

(2012) Binxun Yu et al.   ACS Chemical Biology

Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis

(2012) Renata Kowalczyk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

Positional effects of click cyclization on β-hairpin structure, stability, and function

(2012) Jessica H. Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

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TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

“Triazole Bridge”: Disulfide-Bond Replacement by Ruthenium-Catalyzed Formation of 1,5-Disubstituted 1,2,3-Triazoles

(2011) Martin Empting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

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Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

(2011) María Isabel García-Aranda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways

(2011) Tomoyo Sakata et al.   CHEMICAL SOCIETY REVIEWS

Parallel β-Sheet Secondary Structure Is Stabilized and Terminated by Interstrand Disulfide Cross-Linking

(2011) Aaron M. Almeida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein–protein interactions

(2010) Dennis M. Kr�ger et al.   NUCLEIC ACIDS RESEARCH

Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn Constraint

(2009) Sumana Giddu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS