Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

(2014) Grzegorz Popowicz et al.   CELL CYCLE

Pharmer: Efficient and Exact Pharmacophore Search

(2011) David Ryan Koes et al.   Journal of Chemical Information and Modeling

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

(2010) Anna Czarna et al.   CELL CYCLE

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

(2010) Grzegorz M. Popowicz et al.   CELL CYCLE

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery

(2010) L. M. C. Meireles et al.   NUCLEIC ACIDS RESEARCH

Piperazine Scaffolds via Isocyanide-Based Multicomponent Reactions

(2010) Alexander Dömling et al.   SYNTHESIS-STUTTGART

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

(2010) Christelle Reynès et al.   PLoS Computational Biology

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

Three-Dimensional Pharmacophore Methods in Drug Discovery

(2009) Andrew R. Leach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isoquinolin‐1‐one Inhibitors of the MDM2–p53 Interaction

(2008) Ulli Rothweiler et al.   ChemMedChem

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

The discovery of GSK221149A: A potent and selective oxytocin antagonist

(2007) John Liddle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Towards the development of universal, fast and highly accurate docking/scoring methods: a long way to go

(2007) N Moitessier et al.   BRITISH JOURNAL OF PHARMACOLOGY