Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Published 2013 View Full Article
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Title
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 50, Pages 20224-20229
Publisher
Proceedings of the National Academy of Sciences
Online
2013-11-26
DOI
10.1073/pnas.1314239110
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Note: Only part of the references are listed.- A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
- (2013) T. Lau et al. CANCER RESEARCH
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- (2013) Slobodan Beronja et al. NATURE
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- (2013) Luc G T Morris et al. NATURE GENETICS
- Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers
- (2013) C. R. Pickering et al. Cancer Discovery
- Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
- (2012) K. D. Proffitt et al. CANCER RESEARCH
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML
- (2012) Florian H. Heidel et al. Cell Stem Cell
- Three decades of Wnts: a personal perspective on how a scientific field developed
- (2012) Roel Nusse et al. EMBO JOURNAL
- Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-boundO-Acyltransferase Porcupine
- (2012) Michael E. Dodge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal
- (2012) J. H. van Es et al. MOLECULAR AND CELLULAR BIOLOGY
- Recurrent R-spondin fusions in colon cancer
- (2012) Somasekar Seshagiri et al. NATURE
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
- (2012) Huai-Xiang Hao et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- The Notch signalling system: recent insights into the complexity of a conserved pathway
- (2012) K. G. Guruharsha et al. NATURE REVIEWS GENETICS
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- WNT secretion and signalling in human disease
- (2012) Patrick Herr et al. TRENDS IN MOLECULAR MEDICINE
- Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
- (2012) Nishant Agrawal et al. Cancer Discovery
- Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
- (2011) Steffen Biechele et al. DEVELOPMENTAL BIOLOGY
- Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.
- (2011) Camille Lobry et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
- (2011) N. J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
- (2011) J. J. Barrott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
- (2011) N. Agrawal et al. SCIENCE
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- (2011) N. Stransky et al. SCIENCE
- Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome
- (2010) Andrey I. Khramtsov et al. AMERICAN JOURNAL OF PATHOLOGY
- Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
- (2010) Nick Barker et al. Cell Stem Cell
- β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
- (2010) Felipe C Geyer et al. MODERN PATHOLOGY
- Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
- (2010) Yan Gong et al. PLoS One
- Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
- (2010) S. A. Ettenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
- (2010) Y. Wang et al. SCIENCE
- Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment
- (2009) Shadmehr Demehri et al. CANCER CELL
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
- (2008) Ilaria Malanchi et al. NATURE
- Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations
- (2008) Sheila Unger et al. NATURE GENETICS
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