Advances in targeting the WNT/β-catenin signaling pathway in cancer

Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

(2021) Karmani Shah et al.   PHARMACOLOGICAL RESEARCH

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pan-cancer analysis of whole genomes

(2020)   NATURE

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

(2020) Cody J. Aros et al.   Cell Reports

Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases

(2020) G. Sferrazza et al.   Acta Pharmaceutica Sinica B

Regulation and function of V-ATPases in physiology and disease

(2020) Michael P. Collins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer

(2020) Anton Cheltsov et al.   Scientific Reports

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

(2020) Wei Kan et al.   eLife

Ran GTPase: A Key Player in Tumor Progression and Metastasis

(2020) Zied Boudhraa et al.   Frontiers in Cell and Developmental Biology

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

(2020) Cody J. Aros et al.   Cell Stem Cell

Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells

(2020) Eric Flores-Hernández et al.   CELLULAR SIGNALLING

Artificial Intelligence in Drug Discovery: Into the Great Wide Open

(2020) Jürgen Bajorath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation

(2020) Christin C. Anthony et al.   Genes

An advanced in silico drug discovery platform, 4HF Data Miner for identifying novel targets for tumors and tumor-stroma

(2020) S. Das et al.   EUROPEAN JOURNAL OF CANCER

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

(2019) Jerry Harb et al.   Current Oncology Reports

Wnt traffic from endoplasmic reticulum to filopodia

(2019) Naushad Moti et al.   PLoS One

Modulating Wnt signaling at the root: Porcupine and Wnt acylation

(2019) Viviana I. Torres et al.   PHARMACOLOGY & THERAPEUTICS

A Review of Curcumin and Its Derivatives as Anticancer Agents

(2019) Mhd Tomeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Screening for natural products that affect Wnt signaling activity

(2019) Masami Ishibashi   Journal of Natural Medicines

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

(2019) Dan Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Machine-learning techniques for the prediction of protein–protein interactions

(2019) Debasree Sarkar et al.   JOURNAL OF BIOSCIENCES

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

(2019) Alicia V. Zamudio et al.   MOLECULAR CELL

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers

(2019) Monika Mis et al.   JOURNAL OF CELL BIOLOGY

The functional landscape of the human phosphoproteome

(2019) David Ochoa et al.   NATURE BIOTECHNOLOGY

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

(2019) P. Gainza et al.   NATURE METHODS

A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin

(2019) Kumpei Yamanishi et al.   Science Signaling

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Dishevelled: A masterful conductor of complex Wnt signals

(2018) Monica Sharma et al.   CELLULAR SIGNALLING

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

RAPGEF5 Regulates Nuclear Translocation of β-Catenin

(2018) John N. Griffin et al.   DEVELOPMENTAL CELL

Is β-Catenin a Druggable Target for Cancer Therapy?

(2018) Can Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin

(2018) Yan Zheng et al.   Cell Death & Disease

Targeting molecular pathways in cancer stem cells by natural bioactive compounds

(2018) Danila Cianciosi et al.   PHARMACOLOGICAL RESEARCH

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling

(2018) Youn-Sang Jung et al.   NATURE CELL BIOLOGY

Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions

(2017) Maocai Yan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modulating the wnt signaling pathway with small molecules

(2017) Freddi Huan Tran et al.   PROTEIN SCIENCE

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

(2017) H A Baarsma et al.   THORAX

The regulation of β-catenin activity and function in cancer: therapeutic opportunities

(2017) Shuang Shang et al.   Oncotarget

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

(2017) Maria Wiese et al.   Oncotarget

Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma

(2017) Weiyuan Wang et al.   Theranostics

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

(2017) Huiqiang Dou et al.   Frontiers in Pharmacology

Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells

(2016) Hyun Ji Eo et al.   Biomolecules & Therapeutics

Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies

(2016) Jiwon Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold

(2016) Zhixiang Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development and structural analysis of adenosine site binding tankyrase inhibitors

(2016) Teemu Haikarainen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways

(2016) L. Farahmand et al.   CELL PROLIFERATION

Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors

(2016) Dai Cheng et al.   ACS Medicinal Chemistry Letters

Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway

(2016) MIN XU et al.   Oncology Letters

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy

(2016) Ting Liu et al.   Oncotarget

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin

(2016) Jessica Chinison et al.   Scientific Reports

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

(2015) Laura Novellasdemunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma

(2015) Murat Kara et al.   GENE

Toosendanin inhibits growth and induces apoptosis in colorectal cancer cells through suppression of AKT/GSK-3β/β-catenin pathway

(2015) GE WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of β-Catenin in Zebrafish

(2015) Xiaojie Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio

(2015) Ramakrishna Vadde et al.   Biomed Research International

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation

(2014) Joo-Hyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

A Structural Portrait of the PDZ Domain Family

(2014) Andreas Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

Cancer In Silico Drug Discovery: A Systems Biology Tool for Identifying Candidate Drugs to Target Specific Molecular Tumor Subtypes

(2014) F. A. San Lucas et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the β-catenin nuclear transport pathway in cancer

(2014) Cara Jamieson et al.   SEMINARS IN CANCER BIOLOGY

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2

(2014) Wei Qiu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

gCMAP: user-friendly connectivity mapping with R

(2013) Thomas Sandmann et al.   BIOINFORMATICS

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor

(2013) Andrew Voronkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple functions of the noncanonical Wnt pathway

(2013) Eva Gómez-Orte et al.   TRENDS IN GENETICS

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

(2012) Christina A. Kirby et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

β-Catenin–SOX2 signaling regulates the fate of developing airway epithelium

(2012) Shuichi Hashimoto et al.   JOURNAL OF CELL SCIENCE

Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor

(2012) Hakan Gunaydin et al.   PLoS One

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

(2011) J. Waaler et al.   CANCER RESEARCH

 -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

(2011) W. van Veelen et al.   GUT

Axin Pathway Activity Regulatesin VivopY654-β-catenin Accumulation and Pulmonary Fibrosis

(2011) Arnau Ulsamer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma

(2011) Aleksandra Stanczak et al.   PATHOLOGY & ONCOLOGY RESEARCH

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin

(2010) S. Rajamanickam et al.   CANCER RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Tetrandrine Inhibits Wnt/ -Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer

(2010) B.-C. He et al.   MOLECULAR PHARMACOLOGY

Toosendanin Inhibits Hepatocellular Carcinoma Cells by Inducing Mitochondria-dependent Apoptosis

(2010) Yujuan He et al.   PLANTA MEDICA

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Recruitment of adenomatous polyposis coli and β-catenin to axin-puncta

(2008) M C Faux et al.   ONCOGENE

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE

Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity

(2007) Neeraj Mahindroo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS