Screening-based approaches to identify small molecules that inhibit protein–protein interactions

The thermodynamics of protein interactions with essential first row transition metals

(2016) Fadi Bou-Abdallah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

(2016) H.-Y. Kim et al.   EMBO Molecular Medicine

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

(2016) Pu-Hyeon Cha et al.   Nature Chemical Biology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer

(2016) Zhengyu Li et al.   OncoTargets and Therapy

Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis

(2016) Marija Darkovska Serafimovska et al.   Drug Design Development and Therapy

Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets

(2016) Jie Zhu et al.   MEDICAL SCIENCE MONITOR

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

(2016) Lenard S. Vranckx et al.   EBioMedicine

Spectral surface plasmon resonance imaging for the detection of clenbuterol via three-dimensional immobilization of bioprobes

(2015) Manwen Yao et al.   ANALYTICAL BIOCHEMISTRY

Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein–protein interfaces: Fig. 1.

(2015) Miguel Vázquez et al.   BIOINFORMATICS

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

(2015) H-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

(2015) Chunquan Sheng et al.   CHEMICAL SOCIETY REVIEWS

Alternative modulation of protein–protein interactions by small molecules

(2015) Gerhard Fischer et al.   CURRENT OPINION IN BIOTECHNOLOGY

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists

(2015) Bainan Wu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quantitative structure–activity relationship: promising advances in drug discovery platforms

(2015) Tao Wang et al.   Expert Opinion on Drug Discovery

The Contribution of Missense Mutations in Core and Rim Residues of Protein–Protein Interfaces to Human Disease

(2015) Alessia David et al.   JOURNAL OF MOLECULAR BIOLOGY

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

(2015) Benjamin Cossins et al.   MOLECULES

Flexibility and small pockets at protein–protein interfaces: New insights into druggability

(2015) Harry Jubb et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Predicting Binding Free Energy Change Caused by Point Mutations with Knowledge-Modified MM/PBSA Method

(2015) Marharyta Petukh et al.   PLoS Computational Biology

Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging

(2014) Weizhi Wang et al.   ANALYTICAL CHEMISTRY

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein–Protein Interactions

(2014) Elisa Barile et al.   CHEMICAL REVIEWS

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Finding the rules for successful drug optimisation

(2014) Iskander Yusof et al.   DRUG DISCOVERY TODAY

Protein–protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays

(2014) Sheraz Gul et al.   Expert Opinion on Drug Discovery

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)

(2014) Jonas Demeulemeester et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Predicting the Impact of Missense Mutations on Protein–Protein Binding Affinity

(2014) Minghui Li et al.   Journal of Chemical Theory and Computation

Application of fluorescence resonance energy transfer in protein studies

(2014) Linlin Ma et al.   JOURNAL OF MOLECULAR STRUCTURE

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex

(2014) Jia Gao et al.   PLoS One

NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes

(2014) David M. Dias et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Hot spots in protein–protein interfaces: Towards drug discovery

(2014) Engin Cukuroglu et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions

(2014) Jean M. Lodge et al.   MedChemComm

Chemical Library Screening Using a SPR-Based Inhibition in Solution Assay: Simulations and Experimental Validation

(2013) Laurence Choulier et al.   ANALYTICAL CHEMISTRY

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Methods for the Elucidation of Protein-Small Molecule Interactions

(2013) Amanda McFedries et al.   CHEMISTRY & BIOLOGY

Bridging the past and the future of virology: Surface plasmon resonance as a powerful tool to investigate virus/host interactions

(2013) Marco Rusnati et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein–protein interactions

(2013) Céline M. Labbé et al.   DRUG DISCOVERY TODAY

Can emerging drug classes improve R&D productivity?

(2013) Christoph Meier et al.   DRUG DISCOVERY TODAY

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

(2013) Francisco X. Talamas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug for an 'undruggable' protein

(2013) Nicole M. Baker et al.   NATURE

Engineering of weak helper interactions for high-efficiency FRET probes

(2013) Raik Grünberg et al.   NATURE METHODS

Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins

(2013) Kazuyuki Takakuma et al.   PLoS One

Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction

(2013) Marjolein Schaap et al.   PROTEIN SCIENCE

Druggable Protein Interaction Sites Are More Predisposed to Surface Pocket Formation than the Rest of the Protein Surface

(2013) David K. Johnson et al.   PLoS Computational Biology

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

(2012) Philipp Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plucking the high hanging fruit: A systematic approach for targeting protein–protein interactions

(2012) Monika Raj et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Leap into the Chemical Space of Protein-Protein Interaction Inhibitors

(2012) B. O. Villoutreix et al.   CURRENT PHARMACEUTICAL DESIGN

From protein interaction networks to novel therapeutic strategies

(2012) Samira Jaeger et al.   IUBMB LIFE

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Drug-likeness Analysis of Traditional Chinese Medicines: Prediction of Drug-likeness Using Machine Learning Approaches

(2012) Sheng Tian et al.   MOLECULAR PHARMACEUTICS

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Structural biology and drug discovery for protein–protein interactions

(2012) Harry Jubb et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Fluorescence Polarization/Anisotropy in Diagnostics and Imaging

(2010) David M. Jameson et al.   CHEMICAL REVIEWS

High-throughput screening for modulators of protein–protein interactions: use of photonic crystal biosensors and complementary technologies

(2010) James T. Heeres et al.   CHEMICAL SOCIETY REVIEWS

Fluorescence polarization assays in small molecule screening

(2010) Wendy A Lea et al.   Expert Opinion on Drug Discovery

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal forms

(2010) Q. Xu et al.   NUCLEIC ACIDS RESEARCH

Protein-protein docking benchmark version 4.0

(2010) Howook Hwang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

(2008) X. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA