Modulating protein–protein interactions: the potential of peptides

Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging

(2014) Weizhi Wang et al.   ANALYTICAL CHEMISTRY

An Unusual Protein-Protein Interaction through Coupled Unfolding and Binding

(2014) Tae-Kyung Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Targeting of Rab-GTPase-Effector Interactions

(2014) Jochen Spiegel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction

(2014) Adrian Glas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

(2014) Ziqing Qian et al.   BIOCHEMISTRY

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

‘À la Carte’ Peptide Shuttles: Tools to Increase Their Passage across the Blood-Brain Barrier

(2014) Morteza Malakoutikhah et al.   ChemMedChem

Design and Applications of Protein Epitope Mimetics

(2014) John A. Robinson   CHIMIA

Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1

(2014) Charlotte D’Souza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational and Experimental Studies on β-Sheet Breakers Targeting Aβ1–40Fibrils

(2014) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivering wasp venom for cancer therapy

(2014) Miguel Moreno et al.   JOURNAL OF CONTROLLED RELEASE

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

(2014) Andreas O. Frank et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phage Selection of Photoswitchable Peptide Ligands

(2014) Silvia Bellotto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibiting Epidermal Growth Factor Receptor at a Distance

(2014) Julie K.-L. Sinclair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins

(2014) Wenlong Lian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

(2014) Jason Gavenonis et al.   Nature Chemical Biology

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides

(2014) Yu Heng Lau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

(2014) Y. Ivarsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions

(2014) Jean M. Lodge et al.   MedChemComm

De Novo Designed Library of Linear Helical Peptides: An Exploratory Tool in the Discovery of Protein–Protein Interaction Modulators

(2014) M. Ángeles Bonache et al.   ACS Combinatorial Science

In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells

(2013) Takashi Kawakami et al.   ACS Chemical Biology

Discovery of Light-Responsive Ligands through Screening of a Light-Responsive Genetically Encoded Library

(2013) Mohammad R. Jafari et al.   ACS Chemical Biology

Chemical Library Screening Using a SPR-Based Inhibition in Solution Assay: Simulations and Experimental Validation

(2013) Laurence Choulier et al.   ANALYTICAL CHEMISTRY

A Graphene Oxide-Based Fluorescent Biosensor for the Analysis of Peptide–Receptor Interactions and Imaging in Somatostatin Receptor Subtype 2 Overexpressed Tumor Cells

(2013) Bianying Feng et al.   ANALYTICAL CHEMISTRY

Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

(2013) Laura Nevola et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient α-Helix Induction in a Linear Peptide Chain byN-Capping with a Bridged-tricyclic Diproline Analogue

(2013) Verena Hack et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Constrained Head-to-Tail Cyclic Tetrapeptides by an Imine-Induced Ring-Closing/Contraction Strategy

(2013) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1

(2013) Ravichandran N. Murugan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog

(2013) Benjamí Oller-Salvia et al.   BIOPOLYMERS

Computationally Designed Peptide Inhibitors of the Ubiquitin E3 Ligase SCFFbx4

(2013) Junglim Lee et al.   CHEMBIOCHEM

Phage Display to Identify Nedd8-Mimicking Peptides as Inhibitors of the Nedd8 Transfer Cascade

(2013) Bo Zhao et al.   CHEMBIOCHEM

Using a Fragment-Based Approach To Target Protein-Protein Interactions

(2013) Duncan E. Scott et al.   CHEMBIOCHEM

State-of-the-Art High-Speed Atomic Force Microscopy for Investigation of Single-Molecular Dynamics of Proteins

(2013) Arivazhagan Rajendran et al.   CHEMICAL REVIEWS

Progress towards the development of SH2 domain inhibitors

(2013) Dziyana Kraskouskaya et al.   CHEMICAL SOCIETY REVIEWS

Druggable protein–protein interactions – from hot spots to hot segments

(2013) Nir London et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy

(2013) Simon Attwood et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a multifunctional tool for drug screening against plasmodial protein-protein interactions via surface plasmon resonance

(2013) Lauren E. Boucher et al.   JOURNAL OF MOLECULAR RECOGNITION

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor

(2013) Claudia Cavalluzzo et al.   JOURNAL OF PEPTIDE SCIENCE

A new NMR technique to probe protein–ligand interaction

(2013) J.M.P. Viéville et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface

(2013) Mary S. Golden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Screening Bicyclic Peptide Libraries for Protein–Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist

(2013) Wenlong Lian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

(2013) Yanbin Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

(2013) Elena Miranda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proline Primed Helix Length as a Modulator of the Nuclear Receptor–Coactivator Interaction

(2013) Sascha Fuchs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Engineering of weak helper interactions for high-efficiency FRET probes

(2013) Raik Grünberg et al.   NATURE METHODS

A β-Peptide Agonist of the GLP-1 Receptor, a Class B GPCR

(2013) Elizabeth V. Denton et al.   ORGANIC LETTERS

Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins

(2013) Kazuyuki Takakuma et al.   PLoS One

Synergistic Interactions between Alzheimer’s Aβ40 and Aβ42 on the Surface of Primary Neurons Revealed by Single Molecule Microscopy

(2013) Chun-Chieh Chang et al.   PLoS One

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction

(2013) Marjolein Schaap et al.   PROTEIN SCIENCE

Functional, metal-based crosslinkers for α-helix induction in short peptides

(2013) Sarah J. Smith et al.   Chemical Science

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells

(2013) Charles N. Birts et al.   Chemical Science

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

(2012) Toru Okamoto et al.   ACS Chemical Biology

Stapled Peptides with Improved Potency and Specificity That Activate p53

(2012) Christopher J. Brown et al.   ACS Chemical Biology

Hybrid Organic-Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR

(2012) Rituparna Kundu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

(2012) Philipp Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor-Targeting Miniproteins

(2012) Frederic Zoller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding

(2012) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bio-Inspired Design and Potential Biomedical Applications of a Novel Class of High-Affinity Peptides

(2012) Sunghyun Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor

(2012) Roger Prades et al.   BIOMATERIALS

Peptide Bicycles that Inhibit the Grb2 SH2 Domain

(2012) Justin S. Quartararo et al.   CHEMBIOCHEM

In vitro selection of a photo-responsive peptide aptamer using ribosome display

(2012) Mingzhe Liu et al.   CHEMICAL COMMUNICATIONS

Peptides and peptide conjugates: therapeutics on the upward path

(2012) Verena M Ahrens et al.   Future Medicinal Chemistry

From protein interaction networks to novel therapeutic strategies

(2012) Samira Jaeger et al.   IUBMB LIFE

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling

(2012) Madalina Maftei et al.   JOURNAL OF PEPTIDE SCIENCE

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

(2012) Yollete V. Guillen Schlippe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic force microscopy study of the effect of HER 2 antibody on EGF mediated ErbB ligand–receptor interaction

(2012) Xuejie Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Twice tied tight: Enforcing conformational order in bicyclic peptoid oligomers

(2012) Sidonie B. L. Vollrath et al.   Chemical Science

Structure–activity relationship studies of miniproteins targeting the androgen receptor–coactivator interaction

(2012) Marta Dominguez Seoane et al.   MedChemComm

Flexizymes: Their Evolutionary History and the Origin of Catalytic Function

(2011) Jumpei Morimoto et al.   ACCOUNTS OF CHEMICAL RESEARCH

Shuttle-Mediated Drug Delivery to the Brain

(2011) Morteza Malakoutikhah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis and Characterization of a New Anionic Cell-Penetrating Peptide: SAP(E)

(2011) Irene Martín et al.   CHEMBIOCHEM

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

(2011) Avinash Muppidi et al.   CHEMICAL COMMUNICATIONS

Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues

(2011) Tim Geppert et al.   CHEMISTRY & BIOLOGY

DARPins and other repeat protein scaffolds: advances in engineering and applications

(2011) Ykelien L Boersma et al.   CURRENT OPINION IN BIOTECHNOLOGY

Applications of saturation transfer difference NMR in biological systems

(2011) Anirban Bhunia et al.   DRUG DISCOVERY TODAY

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epitope motif of an anti-nitrotyrosine antibody specific for tyrosine-nitrated peptides revealed by a combination of affinity approaches and mass spectrometry

(2011) Mihaela Drǎguşanu et al.   JOURNAL OF PEPTIDE SCIENCE

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Flexizymes for genetic code reprogramming

(2011) Yuki Goto et al.   Nature Protocols

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

Hydrophobic Binding Hot Spots of Bcl-xL Protein−Protein Interfaces by Cosolvent Molecular Dynamics Simulation

(2011) Chao-Yie Yang et al.   ACS Medicinal Chemistry Letters

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

Cross-linked Peptoid-Based Dimerization Inhibitors of HIV-1 Protease

(2010) Song-Gil Lee et al.   CHEMBIOCHEM

Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome

(2010) Craig R. Braun et al.   CHEMISTRY & BIOLOGY

N-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood−Brain Barrier Shuttles

(2010) Morteza Malakoutikhah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bridged β3-Peptide Inhibitors of p53-hDM2 Complexation: Correlation between Affinity and Cell Permeability

(2010) Arjel D. Bautista et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach

(2010) Anupam Patgiri et al.   Nature Protocols

Synthetic mimetics of protein secondary structure domains

(2010) N. T. Ross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

(2010) Richard T. Bradshaw et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

(2010) Nir London et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Computational Analysis of Protein Hotspots

(2010) Chao-Yie Yang et al.   ACS Medicinal Chemistry Letters

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Peptidic modulators of protein-protein interactions: Progress and challenges in computational design

(2009) Mor Rubinstein et al.   BIOPOLYMERS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

A General Screening Strategy for Peptide-Based Fluorogenic Ligands: Probes for Dynamic Studies of PDZ Domain-Mediated Interactions

(2009) Matthieu Sainlos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Controlling the enzymatic activity of a restriction enzyme by light

(2009) B. Schierling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Peptidic Peptidomimetics

(2008) Dieter Seebach et al.   ACCOUNTS OF CHEMICAL RESEARCH

β-Hairpin Peptidomimetics: Design, Structures and Biological Activities

(2008) John A. Robinson   ACCOUNTS OF CHEMICAL RESEARCH

Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction

(2008) Ali Tavassoli et al.   ACS Chemical Biology

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combination of a SAW-biosensor with MALDI mass spectrometric analysis

(2008) G. Treitz et al.   BIOSENSORS & BIOELECTRONICS

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained viaitoi+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

(2008) Sonia Cantel et al.   JOURNAL OF ORGANIC CHEMISTRY

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY

Construction and Analysis of High-Complexity Ribosome Display Random Peptide Libraries

(2008) Li-Min Yang et al.   PLoS One

Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand

(2008) S. Gordo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly

(2008) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA