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Title
Can we safely target the WNT pathway?
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 7, Pages 513-532
Publisher
Springer Nature
Online
2014-07-01
DOI
10.1038/nrd4233
References
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Note: Only part of the references are listed.- The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
- (2014) W. de Lau et al. GENES & DEVELOPMENT
- -Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells
- (2014) S. Keerthivasan et al. Science Translational Medicine
- Considerations for Targeting β-Catenin Signaling in Fibrosis
- (2013) Cara J. Gottardi et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- β-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis after Intratracheal Bleomycin
- (2013) Harikrishna Tanjore et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling
- (2013) Gernot Hahne et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin
- (2013) Jun Yao et al. CANCER BIOLOGY & THERAPY
- A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
- (2013) T. Lau et al. CANCER RESEARCH
- Wnt signaling in stem and cancer stem cells
- (2013) Jane D Holland et al. CURRENT OPINION IN CELL BIOLOGY
- A membrane-associated -catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells
- (2013) F. Faunes et al. DEVELOPMENT
- TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass
- (2013) Iseki Takamoto et al. DIABETOLOGIA
- Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours
- (2013) Peter Wend et al. EMBO JOURNAL
- Looking beyond the Wnt pathway for the deep nature of β-catenin
- (2013) François Fagotto EMBO REPORTS
- Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies?
- (2013) Clara Dees et al. EXPERIMENTAL DERMATOLOGY
- Tankyrases as drug targets
- (2013) Lari Lehtiö et al. FEBS Journal
- Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway
- (2013) Kaijie He et al. INTERNATIONAL JOURNAL OF CANCER
- Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
- (2013) Steven M. Frisch et al. JOURNAL OF CELL SCIENCE
- Minimal Residual Disease Assessed by Multiparameter Flow Cytometry in Multiple Myeloma: Impact on Outcome in the Medical Research Council Myeloma IX Study
- (2013) Andy C. Rawstron et al. JOURNAL OF CLINICAL ONCOLOGY
- Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis
- (2013) Pedro Cisternas et al. MOLECULAR NEUROBIOLOGY
- Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection
- (2013) Wei-Jie Zhou et al. NATURE
- Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia
- (2013) E J Gang et al. ONCOGENE
- A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype
- (2013) Haytham Aly et al. PLoS One
- The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
- (2013) Tomoyo Sasaki et al. PLoS One
- Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
- (2013) X. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Wnt-er Migration: The Confusing Role of -Catenin in Melanoma Metastasis
- (2013) M. R. Webster et al. Science Signaling
- Multiple functions of the noncanonical Wnt pathway
- (2013) Eva Gómez-Orte et al. TRENDS IN GENETICS
- Wnts in action: from synapse formation to synaptic maintenance
- (2013) Ellen M. Dickins et al. Frontiers in Cellular Neuroscience
- Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer
- (2012) Ze-Guang Han Annual Review of Genomics and Human Genetics
- The importance of Wnt signalling for neurodegeneration in Parkinson's disease
- (2012) Daniel C. Berwick et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Developmental pathways in colon cancer
- (2012) Fred E. Bertrand et al. CELL CYCLE
- Three decades of Wnts: a personal perspective on how a scientific field developed
- (2012) Roel Nusse et al. EMBO JOURNAL
- Drugging Wnt signalling in cancer
- (2012) Paul Polakis EMBO JOURNAL
- Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability
- (2012) Y. Drier et al. GENOME RESEARCH
- Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
- (2012) Nibaldo C. Inestrosa et al. Journal of Neuroimmune Pharmacology
- Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer
- (2012) Ana Chocarro-Calvo et al. MOLECULAR CELL
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
- (2012) Huai-Xiang Hao et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- The complex world of WNT receptor signalling
- (2012) Christof Niehrs NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Oral Hedgehog-Pathway Inhibitors for Basal-Cell Carcinoma
- (2012) John T. Lear NEW ENGLAND JOURNAL OF MEDICINE
- β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer
- (2012) E R M Bakker et al. ONCOGENE
- Inhibition of oncogenic Wnt signaling through direct targeting of -catenin
- (2012) T. N. Grossmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
- (2012) K. Hoffmeyer et al. SCIENCE
- Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling
- (2012) K. Takada et al. Science Translational Medicine
- WNT secretion and signalling in human disease
- (2012) Patrick Herr et al. TRENDS IN MOLECULAR MEDICINE
- Targeting Wnt Pathways in Disease
- (2012) Z. F. Zimmerman et al. Cold Spring Harbor Perspectives in Biology
- Wnt Signaling and Injury Repair
- (2012) J. L. Whyte et al. Cold Spring Harbor Perspectives in Biology
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- (2012) Kouichi Hasegawa et al. Stem Cells Translational Medicine
- The R-spondin protein family
- (2012) Wim BM de Lau et al. GENOME BIOLOGY
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- (2012) Hans Kalkman Molecular Autism
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- (2011) J B Rawson et al. BRITISH JOURNAL OF CANCER
- Tumor Metastasis: Molecular Insights and Evolving Paradigms
- (2011) Scott Valastyan et al. CELL
- Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways
- (2011) Tomoyo Sakata et al. CHEMICAL SOCIETY REVIEWS
- The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells
- (2011) Y.-M. Kim et al. CURRENT CANCER DRUG TARGETS
- Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin
- (2011) Tomohiro Kajiguchi et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Symmetric division versus asymmetric division: a tale of two coactivators
- (2011) Michael Kahn Future Medicinal Chemistry
- -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
- (2011) W. van Veelen et al. GUT
- Axin Pathway Activity Regulatesin VivopY654-β-catenin Accumulation and Pulmonary Fibrosis
- (2011) Arnau Ulsamer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The three R’s of lung health and disease: repair, remodeling, and regeneration
- (2011) Michael F. Beers et al. JOURNAL OF CLINICAL INVESTIGATION
- Synaptic Wnt signaling—a contributor to major psychiatric disorders?
- (2011) Nathan D. Okerlund et al. Journal of Neurodevelopmental Disorders
- Targeted Inhibition of -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis
- (2011) S. Hao et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
- (2011) Wei Wei et al. Molecular Cancer
- A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
- (2011) Francesca L'Episcopo et al. Molecular Neurodegeneration
- Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
- (2011) Stephen P J Fancy et al. NATURE NEUROSCIENCE
- Resistance or sensitivity of Wilms’ tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target
- (2011) N Pode-Shakked et al. ONCOGENE
- β-Catenin is required for Ron receptor-induced mammary tumorigenesis
- (2011) P K Wagh et al. ONCOGENE
- WNT5A Signaling Contributes to Aβ-Induced Neuroinflammation and Neurotoxicity
- (2011) Bei Li et al. PLoS One
- Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- (2011) Desheng Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
- (2011) F. C. Gonsalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling
- (2011) L. S. Jacob et al. Science Signaling
- Crystal Structures of the Armadillo Repeat Domain of Adenomatous Polyposis Coli and Its Complex with the Tyrosine-Rich Domain of Sam68
- (2011) Ella Czarina Morishita et al. STRUCTURE
- Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
- (2011) L Crews et al. Cell Death & Disease
- Thiol-Based Redox Switches and Gene Regulation
- (2010) Haike Antelmann et al. ANTIOXIDANTS & REDOX SIGNALING
- Wnt signal transduction pathway and apoptosis: a review
- (2010) Nives Pećina-Šlaus Cancer Cell International
- Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth
- (2010) Miki Shitashige et al. CANCER RESEARCH
- Targeting Hedgehog -- a Cancer Stem Cell Pathway
- (2010) A. A. Merchant et al. CLINICAL CANCER RESEARCH
- Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
- (2010) F. Takahashi-Yanaga et al. CLINICAL CANCER RESEARCH
- The Difficulty of Targeting Cancer Stem Cell Niches
- (2010) M. A. LaBarge CLINICAL CANCER RESEARCH
- Targeting Notch to Target Cancer Stem Cells
- (2010) A. Pannuti et al. CLINICAL CANCER RESEARCH
- The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling
- (2010) Monica Corada et al. DEVELOPMENTAL CELL
- Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria
- (2010) Lidia Hernandez et al. DEVELOPMENTAL CELL
- Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways
- (2010) Sara Previdi et al. EUROPEAN JOURNAL OF CANCER
- Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
- (2010) Xinyuan Zhou et al. IMMUNITY
- TCF1 and β-catenin regulate T cell development and function
- (2010) Qing Yu et al. IMMUNOLOGIC RESEARCH
- Small Molecules and Stem Cells. Potency and Lineage Commitment: The New Quest for the Fountain of Youth
- (2010) Agnès I. Lukaszewicz et al. JOURNAL OF MEDICINAL CHEMISTRY
- O2 regulates stem cells through Wnt/β-catenin signalling
- (2010) Jolly Mazumdar et al. NATURE CELL BIOLOGY
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- (2010) Curtis A Thorne et al. Nature Chemical Biology
- Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling
- (2010) Sarika Saraswati et al. PLoS One
- Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
- (2010) G. Jeannet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
- (2010) W. R. Henderson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
- (2010) Dimple Notani et al. PLOS BIOLOGY
- 2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer
- (2009) Zecheng Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
- (2009) Yingwei Mao et al. CELL
- Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
- (2009) Piyush B. Gupta et al. CELL
- The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
- (2009) Angelo Cicalese et al. CELL
- Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
- (2009) Shih-Lei Lai et al. CELL RESEARCH
- Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis
- (2009) Sachin Malhotra et al. Cell Stem Cell
- Towards an integrated view of Wnt signaling in development
- (2009) R. van Amerongen et al. DEVELOPMENT
- The kinase TNIK is an essential activator of Wnt target genes
- (2009) Tokameh Mahmoudi et al. EMBO JOURNAL
- Wnt signaling as a therapeutic target for bone diseases
- (2009) Luke H Hoeppner et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Wnt-signalling and the Metabolic Syndrome
- (2009) S. Schinner HORMONE AND METABOLIC RESEARCH
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- (2009) Satdarshan Pal Singh Monga INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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- (2009) Annette S. Flozak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) David Grandy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) D.-M. Zhao et al. JOURNAL OF IMMUNOLOGY
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- (2009) Y. Wang MOLECULAR CANCER THERAPEUTICS
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
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- (2009) Baozhi Chen et al. Nature Chemical Biology
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- (2009) Karel Otero et al. NATURE IMMUNOLOGY
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- (2009) Luca Gattinoni et al. NATURE MEDICINE
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- (2009) Stephane Angers et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2009) Nibaldo C. Inestrosa et al. NATURE REVIEWS NEUROSCIENCE
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- (2009) Jennifer L. Freese et al. NEUROBIOLOGY OF DISEASE
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- (2009) Armando Gabrielli et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) Payel Bhanja et al. PLoS One
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- (2009) Mounira Abiola et al. PLoS One
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- (2009) A. J. Chien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) Michael J. Nemeth et al. STEM CELLS
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